Investigating hyperoxic effects in the rat brain using quantitative susceptibility mapping based on MRI phase

Hsieh, Meng-Chi; Li, Kuo; Huang, Yun‐An; Chen, Jyh-Horng

doi:10.1002/mrm.26139

Cited by 14 publications

(15 citation statements)

References 62 publications

(93 reference statements)

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“…In a previous study, QSM measurements of SvO 2 were performed in the cerebral vasculature of mice and reported changes from ~88% to ~99% in response to hyperoxia. 3 Absolute ShvO 2 values calculated in the current study were lower (~52%, normoxia; ~74%, hyperoxia). Although there is little in the literature concerning ShvO 2 in preclinical experiments, the values measured here are broadly in line with similar experiments in rats (~60% during normoxia).…”

Section: Discussioncontrasting

confidence: 59%

“…The aim of this study was to assess the ability of QSM to measure changes in venous blood oxygenation in the major hepatic vessels of mice in response to a hyperoxic gas challenge. In a previous study, QSM measurements of SvO 2 were performed in the cerebral vasculature of mice and reported changes from ~88% to ~99% in response to hyperoxia . Absolute ShvO 2 values calculated in the current study were lower (~52%, normoxia; ~74%, hyperoxia).…”

Section: Discussionmentioning

confidence: 41%

Section: Introductionmentioning

confidence: 99%

“…The measurement of blood susceptibility and venous oxygen saturation (SvO 2 ) using QSM MRI has been the focus of several studies in recent years . It has been shown in both animal models and humans that QSM can quantify changes in blood deoxyhaemoglobin content brought about by a hyperoxic gas challenge . This measurement can be used together with arterial spin labeling measures of cerebral blood flow to estimate the cerebral metabolic rate of oxygen consumption and can even quantify regional venous oxygenation in the brain .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] It has been shown in both animal models 3 and humans 2,5,6 that QSM can quantify changes in blood deoxyhaemoglobin content brought about by a hyperoxic gas challenge. 2,3 This measurement can be used together with arterial spin labeling measures of cerebral blood flow to estimate the cerebral metabolic rate of oxygen consumption 4 and can even quantify regional venous oxygenation in the brain. 1 To date however, QSM-based SvO 2 research has been carried out exclusively in the cerebral vasculature.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive quantification of oxygen saturation in the portal and hepatic veins in healthy mice and those with colorectal liver metastases using QSM MRI

Finnerty

Ramasawmy

O’Callaghan

et al. 2018

Magnetic Resonance in Med

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Purpose This preclinical study investigated the use of QSM MRI to noninvasively measure venous oxygen saturation (SvO2) in the hepatic and portal veins. Methods QSM data were acquired from a cohort of healthy mice (n = 10) on a 9.4 Tesla MRI scanner under normoxic and hyperoxic conditions. Susceptibility was measured in the portal and hepatic veins and used to calculate SvO2 in each vessel under each condition. Blood was extracted from the inferior vena cava of 3 of the mice under each condition, and SvO2 was measured with a blood gas analyzer for comparison. QSM data were also acquired from a cohort of mice bearing liver tumors under normoxic conditions. Susceptibility was measured, and SvO2 calculated in the portal and hepatic veins and compared to the healthy mice. Statistical significance was assessed using a Wilcoxon matched‐pairs signed rank test (normoxic vs. hyperoxic) or a Mann‐Whitney test (healthy vs. tumor bearing). Results SvO2 calculated from QSM measurements in healthy mice under hyperoxia showed significant increases of 15% in the portal vein ( P < 0.05) and 21% in the hepatic vein ( P < 0.01) versus normoxia. These values agreed with inferior vena cava measurements from the blood gas analyzer (26% increase). SvO2 in the hepatic vein was significantly lower in the colorectal liver metastases cohort (30% ± 11%) than the healthy mice (53% ± 17%) ( P < 0.05); differences in the portal vein were not significant. Conclusion QSM is a feasible tool for noninvasively measuring SvO2 in the liver and can detect differences due to increased oxygen consumption in livers bearing colorectal metastases.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 41%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Noninvasive quantification of oxygen saturation in the portal and hepatic veins in healthy mice and those with colorectal liver metastases using QSM MRI

Finnerty

Ramasawmy

O’Callaghan

et al. 2018

Magnetic Resonance in Med

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Feasibility of QSM in the human placenta

Zun

Kapse

Quistorff

et al. 2020

Magnetic Resonance in Med

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Purpose: Quantitative susceptibility mapping (QSM) is an emerging tool for the precise characterization of human tissue, including regional oxygenation. A critical function of the human placenta is oxygen transfer to the developing fetus, which remains difficult to study in utero. The purpose of this study is to investigate the feasibility of performing QSM in the human placenta in utero. Methods: In healthy pregnant women, 3D gradient echo data of the placenta were acquired with prospective respiratory gating at 1.5 Tesla and 3 Tesla. A brief period (6-7 min) of maternal hyperoxia was induced to increase placental oxygenation in a subset of women scanned at 3 Tesla, and data were acquired before and during oxygen administration. Susceptibility and T * 2 /R * 2 maps were reconstructed from gradient echo data, and mean and SD of these measures within the whole placenta were calculated. Results: A total of 54 women were studied at a mean gestational age of 30.7 ± 4.2 (range: 24 5/7-38 4/7) weeks. Susceptibility and T * 2 maps demonstrated lobular contrast reflecting regional oxygenation difference at both field strengths. SD of susceptibilities, mean R * 2 , and SD of R * 2 of the placenta showed a linear relationship with gestational age (P < .01 for all). These measures were also responsive to maternal hyperoxia, and there was an increasing response with advancing gestational age (P < .01 for all). Conclusion: This study demonstrates the feasibility of performing placental QSM in pregnant women and supports the potential for placental QSM to provide noninvasive in vivo assessment of placental oxygenation.

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Experimental Models of Brain Disease: MRI Contrast Mechanisms for the Assessment of Pathophysiological Status

Thomas¹,

Shmueli²,

Rega³

et al. 2017

Modern Magnetic Resonance

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Investigating hyperoxic effects in the rat brain using quantitative susceptibility mapping based on MRI phase

Cited by 14 publications

References 62 publications

Noninvasive quantification of oxygen saturation in the portal and hepatic veins in healthy mice and those with colorectal liver metastases using QSM MRI

Noninvasive quantification of oxygen saturation in the portal and hepatic veins in healthy mice and those with colorectal liver metastases using QSM MRI

Feasibility of QSM in the human placenta

Experimental Models of Brain Disease: MRI Contrast Mechanisms for the Assessment of Pathophysiological Status

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