Investigating myocardial motion by MRI using tissue phase mapping

Jung, Bernd; Markl, Michael; Föll, Daniela; Hennig, Jürgen

doi:10.1016/j.ejcts.2006.02.066

Cited by 91 publications

(91 citation statements)

References 21 publications

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“…Longitudinal strain assessment has been conducted by PC-MRI in phantom (31) and with short-axis PC-MRI in normal human volunteers (32). Short-axis image through plane errors plague strain evaluation.…”

Section: Discussionmentioning

confidence: 99%

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Dicks

Carlsson

Heiberg

et al. 2009

Magnetic Resonance Imaging

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Purpose:To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain. Materials and Methods:A combined X-ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n ϭ 6). The embolized area at risk was defined on perfusion MRI followed by administration of a 7500 count (size ϭ 100 -300 m) of the embolic agent. Quantification of strain and microinfarction was performed at 1 h and 1 week using PC-MRI and delayed enhancement (DE) MRI, respectively. At postmortem, sliced hearts were stained to define microinfarction.Results: Baseline longitudinal and radial strain did not differ between area-at-risk and remote myocardium. The embolized territory (area at risk) showed significant decline in longitudinal strain from Ϫ11.5 Ϯ 3.2% to 1.8 Ϯ 2.5% at 1 h (P Ͻ 0.05) and Ϫ3.9 Ϯ 1.1% at 1 week (P Ͻ 0.05). Similarly, regional radial strain progressively declined from 23.6 Ϯ 2.5% at baseline to 12.5 Ϯ 3.7% at 1 h (P Ͻ 0.05) and 4.8 Ϯ 5.0% at 1 week (P Ͻ 0.01). The size of microinfarction was not significantly different between DE-MRI and histochemical staining. Conclusion:PC-MRI is sensitive in assessing changes in regional longitudinal and radial strain after coronary embolization. Longitudinal and radial strain of the hyperenhanced patchy microinfarction demonstrates persistent decline over the course of 1 week.

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Section: Discussionmentioning

confidence: 99%

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Dicks

Carlsson

Heiberg

et al. 2009

Magnetic Resonance Imaging

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“…89 Strain measures the extent of myocardial deformation and is free from effects of tethering and translation of adjacent myocardial segments that are associated with tissue Doppler velocities. 90 Speckle-tracking imaging based on two-dimensional automated frame-to-frame tracking (between 40 and 100 frames per s) of unique patterns of natural acoustic markers (speckles) on standard gray-scale B-mode images is independent of myocardial translation and angle dependency inherent to tissue Doppler-derived strain parameters.…”

Section: 66mentioning

confidence: 99%

Hypertension and heart failure: a dysfunction of systole, diastole or both?

et al. 2008

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The pathological myocardial hypertrophy associated with hypertension contains the seed for further maladaptive development. Increased myocardial oxygen consumption, impaired epicardial coronary perfusion, ventricular fibrosis and remodelling, abnormalities in long-axis function and torsion, cause, to a varying degree, a mixture of systolic and diastolic abnormalities. In addition, chronotropic incompetence and peripheral factors such as lack of vasodilator reserve and reduced arterial compliance further affect cardiac output particularly on exercise. Many of these factors are common to hypertensive heart failure with a normal ejection fraction as well as systolic heart failure. There is increasing evidence that these apparently separate phenotypes are part of a spectrum of heart failure differing only in the degree of ventricular remodelling and volume changes. Furthermore, dichotomizing heart failure into systolic and diastolic clinical entities has led to a paucity of clinical trials of therapies for heart failure with a normal ejection fraction. Therapies aimed at reversing myocardial fibrosis, and targets outside the heart such as enhancing vasodilator reserve and improving chronotropic incompetence deserve further study and may improve the exercise capacity of hypertensive heart failure patients. Hypertension heart disease with heart failure is simply not a dysfunction of systole and diastole. Other peripheral factors including heart rate and vasodilator response with exercise may deserve equal attention in an attempt to develop more effective treatments for this disorder.

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“…Buckberg et al (11) explained normal left ventricular mechanical sequences as follows: narrowing, shortening, lengthening and widening. Therefore, we can assume that radial contraction precedes longitudinal or circumferential motion (12). QLAB software provided speed and velocity data in all patients.…”

Section: Discussionmentioning

confidence: 99%

Speckle tracking based myocardial velocities: our experience with novel software

Baysan¹,

Akyol²,

Buğan³

et al. 2010

Anadolu Kardiyol Derg

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Objective: Speckle tracking is a new imaging modality capable of providing information about myocardial motion in all three directions: longitudinal, circumferential and radial. There are many software packages with their unique tracking algorithms and user interfaces in the market. We aimed to evaluate the feasibility of QLAB software in clinical practice and speckle based myocardial velocities in healthy subjects. Methods: Thirty-two subjects were enrolled in the study. Images from apical four-chamber, apical two-chamber, parasternal short-axis (mitral valve-apical levels) views were acquired and analyzed offline with QLAB. We measured speed and velocity data in longitudinal, circumferential and radial directions. Time percent of these events were also calculated. In the final data analysis 825 of 832 segments (99.2%) were included. Mann Whitney U, Student's t and Kendall's tau-b coefficient tests were used for statistical analysis. Results: We determined that circumferential speed was significantly higher (p<0.001) than radial velocity in both parasternal short-axis views. Likewise, longitudinal speed was higher (p<0.001) than radial velocity in apical views. Notwithstanding the speed and velocity data, time percent of radial velocity were significantly lower (p<0.001 for all) than their longitudinal or circumferential counterparts. We also notified that apex was the segment reaching its maximum speed at earliest time. QLAB measurement time was relatively long (8.1±1.7 min) and intraobserver agreement was lost in 3% of the segments. Conclusion: In addition to these findings, we consider QLAB software package for speckle tracking needs some improvements to shorten measurement time and decrease user intervention. (Anadolu Kardiyol Derg 2010; 10: 233-8) Key words: Speckle tracking, QLAB software, myocardial velocities ÖZET Amaç: Benek izleme (speckle tracking), miyokart hareketinin tüm yönleri hakkında (longitüdinal, sirkümferansiyal ve radiyal) bilgi veren yeni bir görüntüleme yöntemidir. Bu amaçla kendi takip algoritmaları ve kullanıcı arabirimlerine sahip birçok yazılım piyasaya sunulmuştur. Biz bu çalış-mada, QLAB yazılımının klinik uygulamada kullanılabilirliğini ve sağlıklı bireylerde miyokart hızlarını benek izleme yöntemiyle değerlendirmeyi amaçladık. Yöntemler: Çalışmaya 32 sağlıklı birey dahil edildi. Apikal 4 oda, apikal 2 oda ve parasternal kısa eksen (mitral kapak ve papiller kas seviyesi) görüntüleri her bireyde alınarak QLAB yazılımıyla incelendi. Longitüdinal, sirkümferansiyal ve radiyal yöndeki hız ve vektöriyel hız verileri ölçül-dü. Bu olayların gerçekleştiği zaman, yüzde olarak hesaplandı. Görüntülenmeye çalışılan 832 segmentten 825'i (%99.2) değerlendirmeye alındı. İstatistiksel analizde Mann Whitney U, Student t ve Kendall's tau-b katsaysı testleri kullanıldı. Bulgular: Sirkümferansiyal hız her iki parasternal kısa eksen kesitlerinde de radiyal hız vektöründen daha fazlaydı (p<0.001). Benzer olarak longitüdinal hız radiyal hız vektöründen apikal kesitlerde daha fazlaydı(p<0.001). Bununla bi...

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Investigating myocardial motion by MRI using tissue phase mapping

Cited by 91 publications

References 21 publications

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded phase contrast magnetic resonance imaging

Hypertension and heart failure: a dysfunction of systole, diastole or both?

Speckle tracking based myocardial velocities: our experience with novel software

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