Investigating the Association between COMMD3 Expression and the Prognosis of Hepatocellular Carcinoma

Cheng, Wei; Cheng, Ziwei; Zhang, Chunsheng; Weng, Lingling; Xing, Dongwei; Zhang, Minguang

doi:10.7150/jca.62454

Cited by 7 publications

(8 citation statements)

References 36 publications

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“…They regulate the proliferation, differentiation, invasion, and influence metastasis of tumor cells, tumor angiogenesis, chemotherapeutic drug resistance, and prognosis of cancer. Current research indicates that the great majority of COMMD proteins, such as COMMD2 ( 21 ), COMMD3 ( 22 ), COMMD4 ( 18 ), COMMD7 ( 7 ), COMMD8 ( 24 ) and COMMD9 ( 20 ), are up-regulated in tumor cells and promote tumor proliferation, invasion, and metastasis. COMMD1 ( 68 , 76 ), COMMD5 ( 83 ), and COMMD10 ( 25 , 91 ) have antitumor effects in general.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, COMMD2 impacts the overall survival of patients with HCC by enhancing tumor immune infiltration ( 21 ). Similarly with COMMD2 , COMMD3 , COMMD7 , and COMMD8 are overexpressed in HCC, increasing cell proliferation, migration, and invasion ( 22 , 24 , 58 ). In HCC patients, COMMD3 upregulation is related with advanced TNM stage, poor overall survival, and vascular invasion.…”

Section: The Commd Protein Family and Tumorsmentioning

confidence: 99%

“…In null mice with subcutaneous xenograft tumors, silencing COMMD3 inhibited tumor development and expression of HIF1α, VEGF, and CD34. In HCC, COMMD3 seemed to operate as an upstream regulator of HIF1α ( 22 ). Several investigations have elaborated on the involvement of COMMD7 in HCC, despite the fact that COMMD7 inhibits NF-κB activation in HEK293T cells ( 72 ).…”

Section: The Commd Protein Family and Tumorsmentioning

confidence: 99%

“…For example, COMMD1 ( 17 ), COMMD4 ( 18 ), COMMD8 ( 19 ), and COMMD9 ( 20 ) regulate the proliferation, invasion, and metastasis of lung cancer. COMMD2 ( 21 ), COMMD3 ( 22 ), COMMD7 ( 23 ), COMMD8 ( 24 ), and COMMD10 ( 25 ) promote or inhibit hepatocellular carcinoma (HCC). Additionally, COMMD1 ( 26 ) and COMMD10 ( 27 ) are linked to drug resistance in tumors.…”

Section: Introductionmentioning

confidence: 99%

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COMMD proteins function and their regulating roles in tumors

et al. 2023

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The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associated with a wide range of disorders, such as hepatitis, myocardial ischemia, cerebral ischemia, HIV infection, and cancer. Among these, the role of COMMD proteins in tumors has been thoroughly explored; they promote or inhibit cancers such as lung cancer, liver cancer, gastric cancer, and prostate cancer. COMMD proteins can influence tumor proliferation, invasion, metastasis, and tumor angiogenesis, which are strongly related to the prognosis of tumors and are possible therapeutic targets for treating tumors. In terms of molecular mechanism, COMMD proteins in tumor cells regulate the oncogenes of NF-κB, HIF, c-MYC, and others, and are related to signaling pathways including apoptosis, autophagy, and ferroptosis. For the clinical diagnosis and therapy of malignancies, additional research into the involvement of COMMD proteins in cancer is beneficial.

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Section: Discussionmentioning

confidence: 99%

Section: The Commd Protein Family and Tumorsmentioning

confidence: 99%

Section: The Commd Protein Family and Tumorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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COMMD proteins function and their regulating roles in tumors

et al. 2023

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“…COMMD1 was found to negatively regulate NF‐κB by controlling the ubiquitination of NF‐κB components and interrupting the dimerization of HIF‐1 alpha/beta to inhibit human cancers 9,12,13 . COMMD3 has been found to be associated with the initiation and development of metastatic prostate and liver malignancies 14,15 . In non‐small cell lung cancer (NSCLC) cells, COMMD4 expression is increased, and siRNA‐mediated COMMD4 knockdown reduces cell proliferation, migration, and viability 16 .…”

Section: Introductionmentioning

confidence: 99%

Multi‐omics analysis of the oncogenic value of copper Metabolism‐Related protein COMMD2 in human cancers

et al. 2022

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Background The copper metabolism MURR1 domain (COMMD) protein family is involved in tumorigenicity of malignant tumors. However, as the member of COMMD, the role of COMMD2 in human tumors remains unknown. Methods We used The Cancer Genome Atlas (TCGA), Genotype Tissue Expression (GTEx), Human Protein Atlas (HPA) database, Cancer Cell Line Encyclopedia (CCLE) platform, univariate Cox regression analysis, Kaplan–Meier curve, cBioPortal, UALCAN database, Sangerbox online platform, GSCA database gene set enrichment analysis (GSEA), and GeneMANIA to analyze the expression of COMMD2, its prognostic values, genomic alteration patterns, and the correlation with tumor stemness, tumor mutational burden (TMB), microsatellite instability (MSI), and immune infiltrates, drug sensitivity, and gene function enrichment in pan‐cancer. qRT‐PCR, CCK‐8, EdU, wound healing, and transwell migration assays were performed to confirm the function of COMMD2. Results COMMD2 was strongly expressed in most cancer types. Elevated COMMD2 expression affects the prognosis, clinicopathological stage, and molecular or immune subtypes of various tumors. Moreover, promoter hypomethylation and mutations in the COMMD2 gene may be associated with its high expression and poor survival. Additionally, we discovered that COMMD2 expression was linked to tumor stemness, TMB, MSI, immune cell infiltration, immune‐checkpoint inhibitors, and drug sensitivity in pan‐cancer. Furthermore, the COMMD2 gene co‐expression network is constructed with GSEA analysis, displaying significant interaction of COMMD2 with E2F targets, G2‐M checkpoint, and mitotic spindle in bladder cancer (BLCA). Finally, RNA interference data showed suppression of COMMD2 prevented proliferation and migration of BLCA and uterine corpus endometrial carcinoma (UCEC) cells. Conclusion Our findings shed light on the COMMD2 functions in human cancers and demonstrate that it is a promising prognostic biomarker and therapeutic target in pan‐cancer.

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