Investigating the effect of tablet thickness and punch curvature on density distribution using finite elements method

Diarra, Harona; Mazel, Vincent; Busignies, Virginie; Tchoreloff, Pierre

doi:10.1016/j.ijpharm.2015.07.030

Cited by 40 publications

(19 citation statements)

References 16 publications

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“…Our optimized powder mixture needs a compression force of 12 kN to manufacture tablets with a tensile strength of 2 MPa. Although the compression force cannot be directly compared between different machines [ 62 ], we can say that our compression force is lower (12 kN) than the force that Choudhari et al required (20 kN) to form tablets with a tensile strength of around 1.6 MPa [ 12 ]. This may be explained by the higher amount of binder (14.3% w / w ) in comparison to the tablet formulation of Choudhari et al (10.0% w / w ).…”

Section: Discussionmentioning

confidence: 99%

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

et al. 2020

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Background: Intestinal nematode infections are usually treated with benzimidazole drugs, but the emergence of resistance to these drugs has led to an increasing demand of new anthelmintic strategies. A new microemulsion formulation (ME) consisting of an Artemisia absinthium extract with proven nematocidal efficacy was previously developed. The aim of our study is to implement a D-optimal mixture design methodology to increase the amount of a silica material (loaded with this ME) in a tablet formulation, considering its tensile strength and disintegration time. Methods: 16 experiments or combinations of the 6 tablet components (loaded silica, microcrystalline cellulose, polyvinylpyrrolidone, croscarmellose, Syloid® 244 FP and magnesium stearate) were assessed. Tensile strength and disintegration time models were developed, and an optimization process was carried out. Results: Tensile strength was improved by increasing the polyvinylpyrrolidone content, while croscarmellose decreased the disintegration time. The optimized powder mixture contains 49.7% w/w of the loaded silica material. A compression force of 12 kN was applied to the powder mixture to form tablets with a tensile strength of 2.0 MPa and a disintegration time of 3.8 min. Conclusions: Our results show that D-optimal mixture designs provide a promising approach to formulate liquid-loaded silica materials.

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Section: Discussionmentioning

confidence: 99%

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

et al. 2020

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“…This shape of expansion has been previously documented for immediate release tablets containing highly plastic, so-called shape-recovery disintegrants (e.g., crospovidone) [23,40]. Since the density of a flat-shaped tablet is greater at the edges [41,42], the release of energy of the compressed MCC particles upon hydration is greater at the edges than in other areas of the tablet, ultimately resulting in the formation of this “hour-glass” shape.…”

Section: Resultsmentioning

confidence: 70%

Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix Performance by the Addition of Co-Excipients

et al. 2019

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Zein is an insoluble, yet swellable, biopolymer that has been extensively studied for its applications in drug delivery. Here, we screened the effect of co-excipients on the swelling and drug release of zein tablets. All throughout the study the behavior of zein was benchmarked against that of hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC). Tablets containing either zein, HPMC, or EC alone or in combination with co-excipients, namely lactose, dicalcium phosphate (DCP), microcrystalline cellulose (MCC), polyvinylpyrrolidone (PVP), or sodium lauryl sulfate (SLS) were prepared by direct compression. Matrix swelling was studied by taking continuous pictures of the tablets over 20 h, using a USB microscope connected to a PC. The overall size change and the axial and radial expansion of the tablets were automatically extrapolated from the pictures by image analysis. Moreover, drug release from tablets containing ternary mixtures of zein, co-excipients and 10% propranolol HCl was also studied. Results showed that zein matrices swelled rapidly at first, but then a plateau was reached, resulting in an initial rapid drug burst followed by slow drug release. HPMC tablets swelled to a greater extent and more gradually, providing a more constant drug release rate. EC did not practically swell, giving a nearly constant drug release pattern. Among the additives studied, only MCC increased the swelling of zein up to nearly three-fold, and thus suppressed drug burst from zein matrices and provided a nearly constant drug release over the test duration. Overall, the incorporation of co-excipients influenced the swelling behavior of zein to a greater extent compared to that of HPMC and EC, indicating that the molecular interactions of zein and additives are clearly more complex and distinct.

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“…The experimental measurements of tablet local density and residual die pressure is used significantly for modelling pharmaceutical tablet [12], [8], [22] and [16] 3 Results and discussion…”

Section: Simulationsmentioning

confidence: 99%

“…Despite the abundance of research on the compaction of convex-faced tablets, the effect of the geometrical parameters of the tablet on the compaction process has received limited attention. Most previous studies [7], [22] focused on the effect of curvature and thickness whereas the effect of tablet's diameter was ignored. Also, to the best of authors' knowledge, shape optimisation of convex-faced tablets is not yet presented in public domain.…”

Section: Introductionmentioning

confidence: 99%

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

2019

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Capping failure, edge chipping, and non-uniform mechanical properties of convexfaced pharmaceutical tablets are common problems in pharma industry. In this paper, Finite Element Modelling (FEM) and Design of Experiment (DoE) techniques are adopted to find the optimal shape of convex-faced (CF) pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping tendency. The effects of the geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and analysed. The finite element model of the tabletting process was generated using the implicit code (ABAQUS) and validated against experimental measurements. Response Surface Methodology (RSM) was employed to establish the relationship between the design variables, represented by the geometrical parameters and the friction coefficient, and compaction responses of interest including residual die pressure, the variation of relative density within the tablet, and the relative shear stress of the edge of the tablet. A statistical-based optimisation approach is then employed to undertake shape optimisation of CF tablets. The obtained results demonstrated how the geometrical parameters of CF tablet and the friction coefficient have significant effects on the compaction behaviour and quality of the pharmaceutical tablet.

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Investigating the effect of tablet thickness and punch curvature on density distribution using finite elements method

Cited by 40 publications

References 16 publications

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration

Swelling of Zein Matrix Tablets Benchmarked against HPMC and Ethylcellulose: Challenging the Matrix Performance by the Addition of Co-Excipients

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

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