Researchers frequently wonder why some entrepreneurs run small and medium-sized businesses (SMEs) more successfully than others and why different SMEs have different survival rates even in the same operational environment. This has resulted in a need to investigate how other factors such as personality, sociology and environtment may mediate relationships between innovations and the growth of SMEs. This research was conducted on entreprenuers in Mataram City. This type of research is quantitative research. The analysis tool uses PLS analysis. It was found that personality has a significant direct and indirect influence on business innovation and business growth at a 10 percent test alpha. The sociological factors have a significant influence on alpha 5.00%, both directly and indirectly on innovation and business growth. Environmental factors are empirically ignored because they do not have a significant direct and indirect influence on business innovation and business growth. The contribution of this study is the clarification of the facts of personality and sociological factor of entrepreneurs and the indication that external environments can impact the business innovation and growth of entreprenuers.