Investigation into complementary and integrative medicine practitioners' clinical experience of intestinal permeability: A cross-sectional survey

Leech, Bradley; Schloss, Janet; Steel, Amie

doi:10.1016/j.ctcp.2018.02.014

Cited by 6 publications

(15 citation statements)

References 61 publications

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“…The clinical relevance of the identified risk factors warrants the attention of healthcare practitioners in their differential diagnosis. IP has previously been recognised by healthcare practitioners to be associated with gastrointestinal conditions more so than any other group of diseases, including metabolic conditions . In our review digestive health symptoms were not identified as a major risk factor for IP.…”

Section: Discussionmentioning

confidence: 67%

“…IP has previously been recognised by healthcare practitioners to be associated with gastrointestinal conditions more so than any other group of diseases, including metabolic conditions. 90 In our review digestive health symptoms were not identified as a major risk factor for IP. In contrast, many conditions such as food sensitivities 9 and histamine intolerance, 91…”

Section: Clinical Significancementioning

confidence: 75%

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Risk factors associated with intestinal permeability in an adult population: A systematic review

et al. 2019

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Background Increased intestinal permeability (IP) involves the loss of integrity between the cells of the small intestine. IP has been suggested to contribute to the pathogenesis and exacerbation of many chronic diseases. Many potential risk factors for IP are proposed in contemporary literature. The purpose of this review is to identify the most significant risk factors for IP. Methods A systematic search of literature published up until September 2018 in the PubMed, EMBASE, CINAHL, and Scopus databases was conducted. Results A total of 47 articles met the inclusion criteria. Elevated levels of proinflammatory markers, dyslipidaemia, hyperglycaemia, insulin resistance, anthropometric measurements resembling obesity, advanced disease severity, comorbidity and the consumption of a Western‐style diet were identified as the strongest risk factors for altered intestinal integrity. The risk of IP increases when coupled with a multiple disease state or combined with other environmental risk factors. Furthermore, many of the identified risk factors such as anthropometric measurements and biomarkers were external from intestinal health and rather resembled a metabolic‐like condition. Conclusions This review identified a number of potential risk factors for IP, ranging from biomarkers to anthropometric measurements, demographics, dietary intake and chronic diseases. These risk factors warrant the attention of clinicians and other healthcare providers to aid the identification of potential patients at risk of altered IP. Further research needs to examine whether the identified risk factors are homogeneous with the diagnosis of IP or whether the disease state influences the association.

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Section: Discussionmentioning

confidence: 67%

Section: Clinical Significancementioning

confidence: 75%

Risk factors associated with intestinal permeability in an adult population: A systematic review

et al. 2019

Self Cite

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“…Previous research has investigated the assessment and management of IP from the practitioner standpoint, where practitioners acknowledge the involvement of IP in many health conditions found in clinical practice. 17 , 18 Within clinical practice, the pathology tests available are invasive, require patients to pay out-of-pocket, and involve a substantial amount of time to perform. 18 Practitioners that frequently treat IP in clinical practice are reported to avoid using validated pathology tests due to the financial cost to the patient and prioritise case history to diagnose IP.…”

Section: Introductionmentioning

confidence: 99%

“… 17 , 18 Within clinical practice, the pathology tests available are invasive, require patients to pay out-of-pocket, and involve a substantial amount of time to perform. 18 Practitioners that frequently treat IP in clinical practice are reported to avoid using validated pathology tests due to the financial cost to the patient and prioritise case history to diagnose IP. 18 While the frequency of methods used by patients, including the accuracy of self-diagnosis remains unknown, the self-diagnosis of other chronic illnesses such as diabetes is considered to be somewhat accurate.…”

Section: Introductionmentioning

confidence: 99%

“… 18 Practitioners that frequently treat IP in clinical practice are reported to avoid using validated pathology tests due to the financial cost to the patient and prioritise case history to diagnose IP. 18 While the frequency of methods used by patients, including the accuracy of self-diagnosis remains unknown, the self-diagnosis of other chronic illnesses such as diabetes is considered to be somewhat accurate. 19 Furthermore, no research to date has considered patients views and preferences towards the assessment and management of IP, resulting in knowledge gaps for evidence-based practice.…”

Section: Introductionmentioning

confidence: 99%

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Health-seeking behaviour, views and preferences of adults with suspected increased intestinal permeability: A cross-sectional survey of Australian adults

Leech

McIntyre

Steel

et al. 2022

Integrative Medicine Research

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Background The public health consequence of increased intestinal permeability (IP) is currently limited by the lack of patient-centred research. This study aims to describe the health-seeking behaviour of Australian adults with suspected IP. Methods A cross-sectional survey of 589 Australian adults who have been diagnosed with IP or have suspected (undiagnosed) IP. Results The majority (56.2%) of participants with suspected IP reported self-diagnosing their condition, with the majority (56.7%) of these participants preferring to be assessed using an accurate method by a general practitioner or naturopath. On average, Australian adults with suspected IP spent 11.1 (95% CI: 9.5, 12.8) years between first suspecting IP and receiving a formal diagnosis. Over the previous 12 months, participants spent an average of $699 on consultation fees, $2176 on dietary supplements for the treatment of IP, and an average of $287 on the assessment of IP. Furthermore, participants who find it difficult to live on their available household income spent significantly more (mean=$2963) on dietary supplements compared to participants who find it easy to live on their available household income ($1918) (p=0.015). Conclusion The investigation of Australian adults with suspected IP found the majority of participants experienced a considerable length of time between first suspecting IP and receiving a diagnosis of IP. The out-of-pocket expenditure associated with the management of IP suggests a financial burden for people with suspected IP. The results of this study provide novel patient-centred considerations that can be used to inform a clinical practice guideline for the management of IP.

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Clinical significance and importance of elevated urinary kryptopyrroles (UKP): Self-reported observations and experience of Australian clinicians using UKP testing

Rainforest

Schloss

Foley

et al. 2021

Advances in Integrative Medicine

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Investigation into complementary and integrative medicine practitioners' clinical experience of intestinal permeability: A cross-sectional survey

Cited by 6 publications

References 61 publications

Risk factors associated with intestinal permeability in an adult population: A systematic review

Risk factors associated with intestinal permeability in an adult population: A systematic review

Health-seeking behaviour, views and preferences of adults with suspected increased intestinal permeability: A cross-sectional survey of Australian adults

Clinical significance and importance of elevated urinary kryptopyrroles (UKP): Self-reported observations and experience of Australian clinicians using UKP testing

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