Investigation into Surface Effects on the Crystal Nucleation and Growth of Clotrimazole Polymorphs

Zhang, Jie; Xu, Meixia; Wu, Shuiqing; Chen, Zhiguo; Luo, Liquan; Zi, Taotao; Peng, Xucong; Yang, Qiusheng; Liu, Minzhuo; Zeng, Zhihong

doi:10.1021/acs.cgd.3c00043

Cited by 6 publications

(11 citation statements)

References 39 publications

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“…The surface chemistry of PA, which includes polar acrylate groups, may facilitate different interactions at the polymer–water interface, impacting the crystallization behavior as shown in studies on the crystallization of amorphous drugs influenced by polymers 43 accounting for the different biomineralization coverage observed. The amide groups of PA can significantly affect surface interactions with the crystallization dynamics, 44 potentially leading to varied coating thickness and crystal morphology.…”

Section: Resultsmentioning

confidence: 99%

Microbial Biomineralization of Alkaline Earth Metal Carbonates on 3D-Printed Surfaces

Natalio,

Maria

2024

ACS Appl. Mater. Interfaces

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The biomineralizing bacterium Sporosarcina pasteurii has attracted considerable interest in the area of geotechnical engineering due to its ability to induce extracellular mineralization. The presented study investigated S. pasteurii's potential to induce the mineralization of alkali-earth metal carbonate coatings on different polymeric 3D-printed flat surfaces fabricated by different additive manufacturing methods. The use of calcium, barium, strontium, or magnesium ions as the source resulted in the formation of vaterite (CaCO 3 ), witherite (BaCO 3 ), strontianite (SrCO 3 ), and nesquehonite MgCO 3 •3H 2 O, respectively. These mineral coatings generally exhibit a compact, yet variable, thickness and are composed of agglomerated microparticles similar to those formed in solution. However, the mechanism behind this clustering remains unclear. The thermal properties of these biologically induced mineral coatings differ from their inorganic counterpart, highlighting the unique characteristics imparted by the biomineralization process. This work seeks to capitalize on the bacterium S. pasteurii's ability to form an alkali-earth metal carbonate coating to expand beyond its traditional use in geoengineering applications. It lays the ground for a novel integration of biologically induced mineralization of single or multilayered and multifunctional coating materials, for example, aerospace applications.

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Section: Resultsmentioning

confidence: 99%

Microbial Biomineralization of Alkaline Earth Metal Carbonates on 3D-Printed Surfaces

Natalio,

Maria

2024

ACS Appl. Mater. Interfaces

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“…However, amorphous solids tend to crystallize because of their higher energy, thus losing the advantages in solubility and dissolution (Zhang, Guo et al, 2023). More importantly, recent studies revealed that crystallization can be much faster at a free surface or interface in comparison with the rates in the interior of amorphous pharmaceutical solids (Shi, Tao et al, 2020;Yu, 2016;Zhang, Xu et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Effects of polyvinylpyrrolidone on the crystallization of amorphous griseofulvin: fracture and molecular mobility

Wang,

Chin,

Shivashekaregowda

et al. 2024

J Appl Cryst

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This study aims to investigate the fracture, molecular mobility and crystallization behaviors of amorphous griseofulvin (GSF) in the presence of polyvinylpyrrolidone (PVP). In the presence of 10%(w/w) PVP K90, the fracture resistance of griseofulvin was greatly improved. Compared with the pure GSF system, the average fracture temperature of the griseofulvin–PVP K90 system was decreased to approximately −6.1°C. More importantly, a statistical study revealed that the direct connection between fracture and nucleation of griseofulvin was weakened in the presence of PVP K90. This study also explored the effects of PVP K90 on the molecular dynamics and crystallization behaviors of amorphous GSF. In the presence of PVP K90, the crystal growth kinetics and molecular dynamics were both slowed down. Interestingly, needle-like crystal growth was observed, exhibiting approximately the same rates as the bubble-induced process. These findings are important for understanding the complex mechanisms of physical stability of polymer-based amorphous solid dispersions.

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“…In this study, we used clotrimazole (CMZ) as a model drug and investigated the impact of P407 on the crystallization of CMZ. CMZ is an antimycotic imidazole agent and is commonly used for studying crystallization [ 24 , 25 ]. Two polymorphs (Form 1 and Form 2) of CMZ have been reported [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…CMZ is an antimycotic imidazole agent and is commonly used for studying crystallization [ 24 , 25 ]. Two polymorphs (Form 1 and Form 2) of CMZ have been reported [ 24 , 25 ]. The metastable Form 2 can only be obtained from melt crystallization and may transform to Form 1 during the melt crystallization [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Two polymorphs (Form 1 and Form 2) of CMZ have been reported [ 24 , 25 ]. The metastable Form 2 can only be obtained from melt crystallization and may transform to Form 1 during the melt crystallization [ 24 , 25 ]. In the present study, the plasticizing effect of P407 was investigated through the change in the glass transition temperature ( Tg ).…”

Section: Introductionmentioning

confidence: 99%

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Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole

Zhang,

Yang,

Luo

et al. 2023

Pharmaceutics

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Surfactants have been widely used as effective additives to increase the solubility and dissolution rates of amorphous solid dispersions (ASDs). However, they may also generate adverse effects on the physical stability of ASDs. In this study, we systematically investigated the impacts of poloxamer, a frequently used surfactant, on the crystallization of amorphous clotrimazole (CMZ). The added poloxamer significantly decreased the glass transition temperature (Tg) of CMZ and accelerated the growth of Form 1 and Form 2 crystals. It was found that the poloxamer had an accelerating effect on Form 1 and Form 2 but showed a larger accelerating effect on Form 1, which resulted from a combined effect of increased mobility and local phase separation at the crystal–liquid interface. Additionally, the added poloxamer exhibited different effects on nucleation of the CMZ polymorphs, which was more complicated than crystal growth. The nucleation rate of Form 1 was significantly increased by the added poloxamer, and the effect increased with increasing P407 content. However, for Form 2, nucleation was slightly decreased or unchanged. The nucleation of Form 2 may have been influenced by the Form 1 crystallization, and Form 2 converted to Form 1 during nucleation. This study increases our understanding of poloxamer and its impacts on the melt crystallization of drugs.

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Investigation into Surface Effects on the Crystal Nucleation and Growth of Clotrimazole Polymorphs

Cited by 6 publications

References 39 publications

Microbial Biomineralization of Alkaline Earth Metal Carbonates on 3D-Printed Surfaces

Microbial Biomineralization of Alkaline Earth Metal Carbonates on 3D-Printed Surfaces

Effects of polyvinylpyrrolidone on the crystallization of amorphous griseofulvin: fracture and molecular mobility

Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole

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