Investigation into the physical properties, antioxidant and antibacterial activity of Bletilla striata polysaccharide/chitosan membranes

Li, Yuan; Ma, Zihao; Yang, Xiao Feng; Gao, Yuanping; Ren, Yimin; Li, Qingmiao; Qu, Yan; Chen, Gongzhen; Zeng, Rui

doi:10.1016/j.ijbiomac.2021.04.037

Cited by 60 publications

(16 citation statements)

References 47 publications

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“…The inhibitory effect of all the developed MB hydrogels on the growth of Staphylococcus aureus and Escherichia coli was very low, at around 6 mm. These findings partly agree with previous reports by Li et al that BSP has no antibacterial effect on these bacteria [ 27 ]. However, according to our findings, even though the developed MB hydrogels possessed low inhibitory properties towards bacteria, they had sufficient levels to inhibit bacteria from attaching to the wound dressing.…”

Section: Discussionsupporting

confidence: 94%

A Polysaccharide Isolated from the Herb Bletilla striata Combined with Methylcellulose to Form a Hydrogel via Self-Assembly as a Wound Dressing

Jakfar

Lin

Chen

et al. 2022

IJMS

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The Bletilla striata Polysaccharide (BSP), a natural polysaccharide derived from the east Asian terrestrial orchid Bletilla striata, is an anti-inflammatory, antiviral, and antioxidant polysaccharide. Traditionally, it has been used to treat hemostasis and for wound healing. In this study, BSP was blended with methylcellulose (MC) and methylparaben (MP) to create a hydrogel through a self-assembly route as a wound dressing. The developed hydrogels were designed as M2Bx, M5Bx, and M8Bx. M stands for MC, and the number represents a percentage. Whereas the second letter of B stands for BSP, and x refers to the percentage variation of BSP: x = 0.5%, 1%, and 2%. All the developed MB hydrogels contained β-glucopyranosyl and α-mannopyranosyl, and rheology test had a tan δ value ≥ 0.5. The pore sizes of the hydrogels decreased by increasing the MC and BSP content, and they had better properties with respect to water loss and their swelling ratio. Evaluations in vitro and in vivo showed that all of the developed MB hydrogels have good cell viability and wound-healing properties. The M8B2 hydrogel group was found to be superior to the others from within the developed MB hydrogels. Therefore, we believe that the M8B2 hydrogel formulation has a high potential for development as a wound dressing.

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Section: Discussionsupporting

confidence: 94%

A Polysaccharide Isolated from the Herb Bletilla striata Combined with Methylcellulose to Form a Hydrogel via Self-Assembly as a Wound Dressing

Jakfar

Lin

Chen

et al. 2022

IJMS

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Section: Discussionmentioning

confidence: 99%

“…CS has attracted considerable attention in food, textiles, agriculture, and especially biomedicine due to its series of features, such as nontoxicity, antibacterial properties, biocompatibility, and biodegradability. 30 The primary amines in the backbone of CS make it an excellent gene carrier for the delivery of DNA, siRNA, and miRNA. In slightly acidic environments, primary amine groups of CS are positively charged, enabling them to bind with negatively charged genetic drugs through electrostatic interactions, resulting in the spontaneous formation of NPs.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer

Yang

Shang

et al. 2021

Mol. Pharmaceutics

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In this study, a chitosan-based, self-assembled nanosystem that codelivered microRNA34a (miR34a) and doxorubicin (Dox) with hyaluronic acid (HA) modification (named CCmDH NPs) was developed to reverse the resistance of breast cancer (BCa) cells to Dox. The CCmDH NPs had a diameter of 180 ± 8.3 nm and a ζ potential of 16.5 mV with a slow-release effect for 96 h. The codelivery system could protect miR34a from nuclease and serum degradation and transport miR34a and Dox into drug-resistant MCF-7/A cells. In addition, the CCmDH NPs could inhibit proliferation and promote apoptosis by regulating the protein expression of B-cell lymphoma-2 (Bcl-2) and poly(ADP-ribose) polymerase (PARP) and inhibit invasion, metastasis, and adhesion by regulating E-cadherin, N-cadherin, MMP2, CD44, and Snail molecules. The CCmDH NPs induced a 73.7% tumor reduction in xenograft tumor growth in nude mice in vivo. This study provides evidence for the anticancer activity of CCmDH NPs carrying Dox and miR34a in BCa, especially metastatic Dox-resistant BCa models.

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“…Chitosan, due to its biological and physico-chemical properties, is commonly used as membrane components that have a variety of applications, such as wound healing membranes [211][212][213][214][215], antibacterial membranes [216][217][218][219], membranes [220] and drug carrier systems [221][222][223].…”

Section: Chitosan Membranesmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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Chitosan is one of the most well-known and characterized materials applied in tissue engineering. Due to its unique chemical, biological and physical properties chitosan is frequently used as the main component in a variety of biomaterials such as membranes, scaffolds, drug carriers, hydrogels and, lastly, as a component of bio-ink dedicated to medical applications. Chitosan’s chemical structure and presence of active chemical groups allow for modification for tailoring material to meet specific requirements according to intended use such as adequate endurance, mechanical properties or biodegradability time. Chitosan can be blended with natural (gelatin, hyaluronic acid, collagen, silk, alginate, agarose, starch, cellulose, carbon nanotubes, natural rubber latex, κ-carrageenan) and synthetic (PVA, PEO, PVP, PNIPPAm PCL, PLA, PLLA, PAA) polymers as well as with other promising materials such as aloe vera, silica, MMt and many more. Chitosan has several derivates: carboxymethylated, acylated, quaternary ammonium, thiolated, and grafted chitosan. Its versatility and comprehensiveness are confirming by further chitosan utilization as a leading constituent of innovative bio-inks applied for tissue engineering. This review examines all the aspects described above, as well as is focusing on a novel application of chitosan and its modifications, including the 3D bioprinting technique which shows great potential among other techniques applied to biomaterials fabrication.

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Investigation into the physical properties, antioxidant and antibacterial activity of Bletilla striata polysaccharide/chitosan membranes

Cited by 60 publications

References 47 publications

A Polysaccharide Isolated from the Herb Bletilla striata Combined with Methylcellulose to Form a Hydrogel via Self-Assembly as a Wound Dressing

A Polysaccharide Isolated from the Herb Bletilla striata Combined with Methylcellulose to Form a Hydrogel via Self-Assembly as a Wound Dressing

Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer

Chitosan as an Underrated Polymer in Modern Tissue Engineering

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