Investigation of a nosocomial outbreak of extended-spectrum β-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a hospital setting

Carbonne, A.; Naas, Thierry; Blanckaert, K.; Couzigou, C.; Cattöen, C.; Chagnon, Jean-Luc; Nordmann, Patrice; Astagneau, Pascal

doi:10.1016/j.jhin.2004.07.027

Cited by 41 publications

(29 citation statements)

References 15 publications

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“…More recent focus has been on VEB-1, which disseminated throughout hospitals in France (clonal dissemination) and was also recently reported from Belgium and Argentina (VEB-1a) (71,381,382,417,442); PER-1, from France, Turkey, Belgium, Romania, Korea, and the United States (250,381,385,439,565,611); and PER-2, from Argentina (417). Interestingly, bla VEB-1 was found to be integron borne (class 1) yet encoded on the chromosome (442).…”

Section: ␤-Lactamsmentioning

confidence: 93%

“…Numerous studies have assessed antibiotic risk factors for infection with multidrug-resistant A. baumannii, although only a few have examined risk factors for emergence of pandrug resistance. Although exposure to any antibiotic active against gram-negative bacteria has been associated with the emergence of multidrug-resistant A. baumannii (359), three classes of antibiotics have been implicated most frequently, including broad-spectrum cephalosporins (71,251,309,483), carbapenems (103,120,321), and fluoroquinolones (586).…”

Section: Hospital Outbreaks and Control Measuresmentioning

confidence: 99%

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Acinetobacter baumannii : Emergence of a Successful Pathogen

2008

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SUMMARY Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.

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Section: ␤-Lactamsmentioning

confidence: 93%

Section: Hospital Outbreaks and Control Measuresmentioning

confidence: 99%

Acinetobacter baumannii : Emergence of a Successful Pathogen

2008

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“…The gene has subsequently been detected in several gram-negative species from Thailand and Vietnam, emphasizing the spread of VEB-1 ␤-lactamase in East Asian countries (5,7,12,13,15,17,24,25,26,43). In addition, VEB-1 has been detected in P. aeruginosa isolates from Kuwait (34), in Acinetobacter baumannii isolates from France (6,32), in P. aeruginosa isolates from India (2) and, recently, in Providencia stuartii isolates from Algeria (3).…”

mentioning

confidence: 99%

Complex Genetic Structures with Repeated Elements, a sul -Type Class 1 Integron, and the bla _VEB Extended-Spectrum β-Lactamase Gene

Naas

Aubert

Lambert

et al. 2006

Antimicrob Agents Chemother

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Two clinical isolates of Pseudomonas aeruginosa, TL-1 and TL-2, were isolated from a patient transferred from Bangladesh and hospitalized for osteomyelitis in Paris, France. P. aeruginosa TL-1 expressed the extendedspectrum ␤-lactamase VEB-1a and was susceptible only to imipenem and colistin, while P. aeruginosa TL-2 expressed only the naturally occurring bla AmpC gene at a basal level and exhibited a wild-type ␤-lactam resistance phenotype. In TL-1, the typical 5-end conserved sequence (5-CS) region of class 1 integrons usually present upstream of the bla VEB-1a gene was replaced by a truncated 3-CS and a 135-bp repeated element (Re). Downstream of the bla VEB-1a gene, an insertion sequence, ISPa31 disrupted by ISPa30, and an orf513 sequence, belonging to a common region (conserved region 1 [CR1]) immediately upstream of the aphA-6 gene, were present. Further downstream, a second truncated 3-CS region in direct repeat belonged to In51, an integron containing two gene cassettes (aadA6 and the OrfD cassette). Thus, the overall structure corresponded to a sul-type class 1 integron termed In121. Genetic analyses revealed that both isolates were clonally related and differed by a ca. 100-kb fragment that contained In121. Both isolates contained another integron, In122, that carried three gene cassettes: aadB, dfrA1, and the OrfX cassette. This work identifies for the first time the spread of Re-associated bla VEB genes located on a sul-type integron. It also reports for the first time a CR1 element in P. aeruginosa that is associated with an aminoglycoside resistance aphA-6 gene that is expressed from a composite promoter.

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“…Several studies have identified that previous antibiotic treatment was the only risk factor for A. baumannii acquisition (Zarrilli et al, 2004;Carbonne et al, 2005). Hence an appropriate use of antibiotic is critical to reduce the emergence of new multi-drug resistant strains (Coelho et al, 2004;Jain and Danziger, 2004).…”

Section: Availability Of Appropriate Prophylaxis and Therapiesmentioning

confidence: 99%

Safety Assessment of Transgenic Organisms, Volume 4

2010

Harmonisation of Regulatory Oversight in Biotechnology

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Investigation of a nosocomial outbreak of extended-spectrum β-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a hospital setting

Cited by 41 publications

References 15 publications

Acinetobacter baumannii : Emergence of a Successful Pathogen

Acinetobacter baumannii : Emergence of a Successful Pathogen

Complex Genetic Structures with Repeated Elements, a sul -Type Class 1 Integron, and the bla _VEB Extended-Spectrum β-Lactamase Gene

Safety Assessment of Transgenic Organisms, Volume 4

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Investigation of a nosocomial outbreak of extended-spectrum β-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a hospital setting

Cited by 41 publications

References 15 publications

Acinetobacter baumannii : Emergence of a Successful Pathogen

Acinetobacter baumannii : Emergence of a Successful Pathogen

Complex Genetic Structures with Repeated Elements, a sul -Type Class 1 Integron, and the bla VEB Extended-Spectrum β-Lactamase Gene

Safety Assessment of Transgenic Organisms, Volume 4

Contact Info

Product

Resources

About

Complex Genetic Structures with Repeated Elements, a sul -Type Class 1 Integron, and the bla _VEB Extended-Spectrum β-Lactamase Gene