Investigation of Mast Cells in Human Gingiva Following Low-Intensity Laser Irradiation

Silveira, Lívio Barros; Prates, Renato Araújo; Novelli, Moacyr Domingos; Marigo, Helenicede Andrade; Garrocho, A.A.; Amorim, José Cláudio Faria; Sousa, Gerdal Roberto de; Pinotti, Marcos; Ribeiro, Martha S.

doi:10.1089/pho.2007.2140

Cited by 35 publications

(12 citation statements)

References 34 publications

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“…Attenuating pain, stimulating endorphin release and modulating the immune system are some of the effects caused by LLLT. LLLT can also influence the wound healing process by the transformation of fibroblasts into myofibroblasts, which are responsible for wound contraction (19,20). In addition, the use of prophylactic laser seems to be more efficient than the AH prophylactic use (12).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis

et al. 2010

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This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM). A prospective, comparative and non-randomized study was conducted with 25 patients with head and neck cancer subjected to radiotherapy (RT) or radiochemotherapy (RCT). Twelve patients received LLLT (830 nm, 15 mW, 12 J/cm²) daily from the 1st day until the end of RT before each sessions during 5 consecutive days, and the other 13 patients received AH 310 mg/5 mL, 4 times/day, also throughout the duration of RT, including weekends. OM was measured using an oral toxicity scale (OTS) and pain was measured using the visual analogue scale (VAS). EORTC questionnaires were administered to the evaluate impact of OM on quality of life. The LLLT group showed lower mean OTS and VAS scores during the course of RT. A significant difference was observed in pain evaluation in the 13th RT session (p=0.036). In both groups, no interruption of RT was needed. The prophylactic use of both treatments proposed in this study seems to reduce the incidence of severe OM lesions. However, the LLLT was more effective in delaying the appearance of severe OM.

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Section: Discussionmentioning

confidence: 99%

Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis

et al. 2010

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“…To date, several mechanisms of biological action have been proposed, although none have been clearly established. These include augmentation of cellular ATP levels [18–20], manipulation of inducible nitric oxide synthase (iNOS) activity [21–25], suppression of inflammatory cytokines, such as TNF-alpha [19,26–28], IL-1beta [28–30], IL-6 [28,31–34] and IL-8 [28,31,32,35], upregulation of growth factors, such as PDGF, IGF-1, NGF and FGF-2 [30,36–38], alteration of mitochondrial membrane potential [39–42], due to chromophores found in the mitochondrial respiratory chain [43–45], stimulation of protein kinase C (PKC) activation [46], manipulation of NF-kappaB activation [47], induction of reactive oxygen species (ROS) [48,49], modification of extracellular matrix components [50], inhibition of apoptosis [39], stimulation of mast cell degranulation [51] and upregulation of heat shock proteins [52]. We have also proposed that LLLT influences cell differentiation following laser stimulation [53–55].…”

Section: Low-level Laser Therapy (Lllt) and Its Effects On Mirna Ementioning

confidence: 99%

Regulation of miRNA Expression by Low-Level Laser Therapy (LLLT) and Photodynamic Therapy (PDT)

Kubota

Hirasawa

Okawa

et al. 2013

IJMS

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Applications of laser therapy, including low-level laser therapy (LLLT), phototherapy and photodynamic therapy (PDT), have been proven to be beneficial and relatively less invasive therapeutic modalities for numerous diseases and disease conditions. Using specific types of laser irradiation, specific cellular activities can be induced. Because multiple cellular signaling cascades are simultaneously activated in cells exposed to lasers, understanding the molecular responses within cells will aid in the development of laser therapies. In order to understand in detail the molecular mechanisms of LLLT and PDT-related responses, it will be useful to characterize the specific expression of miRNAs and proteins. Such analyses will provide an important source for new applications of laser therapy, as well as for the development of individualized treatments. Although several miRNAs should be up- or down-regulated upon stimulation by LLLT, phototherapy and PDT, very few published studies address the effect of laser therapy on miRNA expression. In this review, we focus on LLLT, phototherapy and PDT as representative laser therapies and discuss the effects of these therapies on miRNA expression.

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“…These include augmentation of cellular ATP levels [29], manipulation of inducible nitric oxide synthase (iNOS) activity [30,31], suppression of inflammatory cytokines such as TNF-alpha, IL-1beta, IL-6 and IL-8 [32-36], upregulation of growth factor production such as PDGF, IGF-1, NGF and FGF-2 [36-39], alteration of mitochondrial membrane potential [29,40-42] due to chromophores found in the mitochondrial respiratory chain [43,44] as reviewed in [45], stimulation of protein kinase C (PKC) activation [46], manipulation of NF-κB activation [47], direct bacteriotoxic effect mediated by induction of reactive oxygen species (ROS) [48], modification of extracellular matrix components [49], inhibition of apoptosis [29], stimulation of mast cell degranulation [50], and upregulation of heat shock proteins [51]. Unfortunately these effects have been demonstrated using a variety of LLL devices in non-comparable models.…”

Section: What Is Low Level Laser Irradiation?mentioning

confidence: 99%

Lasers, stem cells, and COPD

et al. 2010

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The medical use of low level laser (LLL) irradiation has been occurring for decades, primarily in the area of tissue healing and inflammatory conditions. Despite little mechanistic knowledge, the concept of a non-invasive, non-thermal intervention that has the potential to modulate regenerative processes is worthy of attention when searching for novel methods of augmenting stem cell-based therapies. Here we discuss the use of LLL irradiation as a "photoceutical" for enhancing production of stem cell growth/chemoattractant factors, stimulation of angiogenesis, and directly augmenting proliferation of stem cells. The combination of LLL together with allogeneic and autologous stem cells, as well as post-mobilization directing of stem cells will be discussed.

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Investigation of Mast Cells in Human Gingiva Following Low-Intensity Laser Irradiation

Cited by 35 publications

References 34 publications

Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis

Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis

Regulation of miRNA Expression by Low-Level Laser Therapy (LLLT) and Photodynamic Therapy (PDT)

Lasers, stem cells, and COPD

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