Investigation of the psychotropic activity of 3-tert-butylaminoacylindoles

Chemistry of 3-(2-Haloacyl)indoles

“…[92] The reaction of 3-α-haloacylindoles (1b,7b) with t-butylamine in isopropyl alcohol at 75-80 º C afforded aminoacylindoles (105a,b), have pharmacological properties that are characteristic for substances with antidepressive activity (Scheme 31). [93] The reaction of 3-chloroacetylindole (1b) with O,O-dihydrogen phosphorothioate derivative (106) in DMF in the presence of triethylamine afforded (107) in 51% yield. [94] In the same manner, (1b) was reacted with ethanolamine under the same experimental conditions gave bisindole derivative (108) in low yield.…”