Investigation on the association between atopic dermatitis and the development of mycosis fungoides in dogs: a retrospective case‐control study

Santoro, Domenico; Marsella, R.; Hernández, Jorge A.

doi:10.1111/j.1365-3164.2007.00582.x

Cited by 40 publications

(42 citation statements)

References 57 publications

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“…However, this hypothesis is not supported by recent studies. 19,20 A history of chronic dermatitis before the development of CETL has also been proposed in dogs, [21][22][23] but a recent study of 25 cases of canine CETL did not report prior chronic dermatitis in any patient. 2 For the historical feline cases, 5-10 the median time between the onset of first lesions until the final diagnosis of CETL was 3.5 months (range 2.5-10 months, n = 4).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous epitheliotropic T‐cell lymphoma in the cat: a review of the literature and five new cases

Fontaine

Heimann²,

Day

2011

Veterinary Dermatology

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Cutaneous epitheliotropic T-cell lymphoma (CETL) is characterized by cutaneous infiltration of neoplastic T lymphocytes with a specific tropism for the epidermis and adnexal epithelium. This disease is reported very rarely in the cat. Clinical data were collected from an informal discussion with veterinary dermatologists through the Vetdermlist (vetderm@lists.ncsu.edu). In parallel, case archives of two European diagnostic histopathology laboratories (Institut de Pathologie et Génétique/Bio.be Gosselies, Belgium and the School of Veterinary Sciences, University of Bristol, UK) were reviewed. Fifteen cases with a good clinical description were selected, and five sets of skin biopsies were available for review. Cutaneous epitheliotropic T-cell lymphoma generally affects older cats with no apparent sex or breed predisposition. Solitary or multiple lesions were reported without predilection for any particular location. The lesions consisted of erythematous plaques or patches, scaly alopecic patches and nonhealing ulcers or nodules, which sometimes mimicked an eosinophilic plaque. Pruritus was rarely reported. No lesions affecting the oral mucosa were observed. Clinical diagnosis of CETL is more challenging in cats than in dogs. Final diagnosis must be based on histopathological examination of skin biopsy samples. The characteristic lesions of feline CETL are similar to those reported in the dog, but involvement of the adnexal glands was not observed in this series (n=5). The neoplastic T cells were generally small to medium in size. The survival time of cats with CETL seems to be more variable than that of affected dogs. Too few cases have been evaluated to permit clear recommendations to be made with respect to treatment.

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Section: Discussionmentioning

confidence: 99%

Cutaneous epitheliotropic T‐cell lymphoma in the cat: a review of the literature and five new cases

Fontaine

Heimann²,

Day

2011

Veterinary Dermatology

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“…[1][2][3][4][5][6][7][8] Other factors related to environmental effects have also been implicated, including exposure to herbicides and other chemicals, [9][10][11][12] residing in an industrial area 9,13,14 and exposure to strong magnetic fields. 15 There is further evidence for increased risk associated with a history of immune-mediated thrombocytopenia, 16 atopic dermatitis 17 and gammaherpesvirus infections. 18 Breed predisposition indicates a potential genetic component for the risk of developing disease.…”

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confidence: 99%

Lymphoma in Australian Border Collies: survey results and pedigree analyses

et al. 2019

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Objectives The aims of this study were to (1) describe the results of a survey on the clinical features of lymphoma in Australian Border Collies and (2) investigate familial clustering of lymphoma‐affected dogs by means of pedigree analyses. Methods Clinical and pedigree information was collected from surveys completed by owners or breeders of Australian Border Collies. Relationships between dogs were derived from pedigree data and kinship was analysed by network and cluster‐based algorithms. Results A total of 246 respondents completed the survey and 57 lymphoma‐affected Australian Border Collies were identified. The mean age of diagnosis was 9.16 (SD ± 3.43) years and the median was 9.7 years (range 2–15 years). The odds of female dogs affected with lymphoma were twice those of males in the reported data (OR = 2.06; 95% CI = 1.13–3.73; P = 0.02). Multicentric, high‐grade B‐cell lymphoma was the most common form in these dogs. Pedigree analyses identified 21 affected dogs that descended from two sires and 28 cases with a common female ancestor. Average inbreeding between both affected and unaffected dogs was similar (0.16, SD ± 0.06 and 0.15, SD ± 0.06, respectively). Conclusion The survey confirmed the presence of a relatively large number of cases of lymphoma in Australian Border Collies, consistent with our previous report of increased risk in this breed. Some dogs were diagnosed at a very young age, but the age ranged over the normal lifespan. Pedigree analyses identified multiple cases within family groups, suggesting a heritable component of the disease in this breed.

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“…1,2 The number of mycosis fungoides cases with a history of atopic dermatitis has increased in the last decade. 5 The mechanisms for this association have not been elucidated. Factors that are common in both illnesses include the crucial role of CD4+ T-cells, an analogue cytokine background, the potential role of immunoglobulin E antibodies, and persistent antigenic stimulation by bacteria that may modify T-cell functionality, resulting in proliferation and malignant transformation.…”

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confidence: 99%