Investigations on the antimicrobial activity of chitosan/PVA nanoparticle loaded nanofibers

Abstract

Purpose In the past decade, the biopolymeric properties of chitosan (CH) have been largely exploited for various applications. This paper aims to study the use of CH in its nanoform, i.e. as nanofibers blended with polyvinyl alcohol (PVA) for various antimicrobial applications in detail. In particular, their ability toward bacterial growth inhibition, in vitro drug release and their biocompatibility toward tissue growth have been investigated in detail. Design/methodology/approach Electrospinning technique was adapted for depositing CH/PVA blended nanofilms on the silver foil under optimized conditions of high voltage. Three different concentrations of blended nanofiber samples were prepared and their antimicrobial properties were studied. Findings The bead diameter and average diameter of blended nanofibers increase with CH concentration. Antibacterial activity increases as CH concentration increases. Increased hydrophilicity in CH-enriched samples contributes to a higher drug release profile. Originality/value To the best of the authors’ knowledge, chick chorioallantoic membrane assay analysis has been carried out for the first time for CH/PVA films which shows that CH/PVA blends are biocompatible. CH after being converted as nanoparticles exhibits higher drug release rate by in vitro method.