Invited Review. the technique and scope of electron-probe x-ray analysis in pathology

Ghadially, F. N.

doi:10.3109/00313027909063544

Cited by 40 publications

(8 citation statements)

References 40 publications

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“…Energy dispersive X‐ray microanalysis or energy dispersive spectrometry may detect elemental composition from Na upward at sensitivity in the order of 10 –18 g 11 . The technique is based on the principle that a characteristic spectrum of X‐rays is generated when a high‐energy electron beam strikes a specimen.…”

Section: Discussionmentioning

confidence: 99%

Calcification of intraocular hydrogel lens: evidence of dystrophic calcification

Yong¹,

Lertsumitkul

Killingsworth³

et al. 2004

Clinical Exper Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Calcification of intraocular hydrogel lens: evidence of dystrophic calcification

Yong¹,

Lertsumitkul

Killingsworth³

et al. 2004

Clinical Exper Ophthalmology

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“…The total amount of iron in the alveolar macrophages can be quantified using cytochemical (Perls), colorimetric (ferrozine), or particle-induced X-ray emission techniques [62,63]. The iron sources in the lungs are: circulatory, where it is bound to transferrin or lactoferrin, inhalatory (from cigarette smoke or metallic dusts); or from the red cell metabolism during episodes of alveolar haemorrhage.…”

Section: Metabolic Theorymentioning

confidence: 99%

Idiopathic pulmonary haemosiderosis revisited

Ioachimescu¹,

Sieber²,

Kotch³

2004

Eur Respir J

206

199

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Idiopathic pulmonary haemosiderosis is a rare cause of diffuse alveolar haemorrhage of unknown aetiology. It occurs most frequently in children, has a variable natural history with repetitive episodes of diffuse alveolar haemorrhage, and has been reported to have a high mortality. Many patients develop iron deficiency anaemia secondary to deposition of haemosiderin iron in the alveoli.Examination of sputum and bronchoalveolar lavage fluid can disclose haemosiderinladen alveolar macrophages (siderophages), and the lung biopsy shows numerous siderophages in the alveoli, without any evidence of pulmonary vasculitis, nonspecific/ granulomatous inflammation, or deposition of immunoglobulins. Contrary to earlier reports, corticosteroids alone or in combination with other immunosuppressive agents may be effective for either exacerbations or maintenance therapy of idiopathic pulmonary haemosiderosis.

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“…Numerous techniques have been developed for determination of subcellular distribution of ions by X-ray microanalysis [5,6]. However, in the present study we are dealing with extracellularly located particles of supracellular magnitude.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the recently developed technique of X-ray micro analysis provides a simultaneous determination of elemen tal composition of a selected area, performed under visual control [4][5][6]. For this reason X-ray dispersive micro analysis is potentially an important tool in the examination of the chemical composition of calcificates.…”

mentioning

confidence: 99%

X-Ray Microanalysis of Uremic Nephrocalcinosis

Goligorsky

Chaimovitz

Rapoport

et al. 1983

Nephron

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The nature of uremic nephrocalcinosis was studied by means of X-ray microanalysis in 5/6 nephrectomized rats. The data show that calcified deposits in the renal parenchyma of uremic rats contained substantial amounts of calcium, magnesium, aluminum and silicon. Since calcificates did not reveal a uniform composition they were arbitrarily divided into 3 categories: ‘high-calcium’ with Mg: Al: Si: Ca molar ratios 7:3:8:37; ‘low-calcium’ particles were characterized by Fe:Mg:Al:Ca:Si molar ratios 7:3:5:6:13; while ‘intermediate-calcium’ particles showed Al: Mg: Si: Ca molar ratios equivalent to 2:4:6:7. The variability of calcified deposits in the renal parenchyma of 5/6 nephrectomized rats might be due to different sources, different environmental conditions along the nephron and different stages of calcification process. It is suggested that aluminum and silicon content of deposits may be of value in further characterization of uremic nephrocalcinosis.

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Invited Review. the technique and scope of electron-probe x-ray analysis in pathology

Cited by 40 publications

References 40 publications

Calcification of intraocular hydrogel lens: evidence of dystrophic calcification

Calcification of intraocular hydrogel lens: evidence of dystrophic calcification

Idiopathic pulmonary haemosiderosis revisited

X-Ray Microanalysis of Uremic Nephrocalcinosis

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