(Invited) The Next Generation Biochip

Abstract

Biochip in the form of microarray is an ingenious way to collect large amount of biochemical information. This method is especially suited for the current big data era when large amount of genomic and proteomic information are analyzed to answer many medical questions including aging, chronical diseases and personal medicine. However, applications of traditional biochip array are facing some major limitations, such as labeling requirement, specificity and sensitivity issues, and cost, which prevent many of its biomedical applications. Current technologies available in semiconductor and electronics industries may help to eliminate most, if not all, of these barriers. We propose the development of a Next Generation bioChip (NGC) that fulfills the unmet needs of current biochip to face the growing demand in health care. By using polysilicon nanowire field effect transistor base biosensor, we demonstrate that the NGC can be achieved with current technologies and can be built in the near future.