“…For instance, ITSs were often found at translocation junctions in patients with Prader-Willi syndrome [302,303,304,305,306,307], Dandy-Walker malformation [308] and hematopoietic malignancies including acute myeloid leukemia (AML) [309,310,311]. Several reports show involvement of ITSs in constitutional chromosomal abnormalities [307,312,313,314]. ITSs were also found at breakpoints of unbalanced translocations observed in neuroblastoma [315].…”