2013
DOI: 10.1097/aci.0b013e328364ea3a
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Involvement of lymphocytes in asthma and allergic diseases

Abstract: Plenty of genetic loci of lymphocyte regulation provide us a deeper insight into the asthma pathogenesis. Future challenge is to define genetic drivers in asthma phenotypes to provide therapeutic targets.

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Cited by 6 publications
(3 citation statements)
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“…Eosinophils in the airways are drawn in and stimulated, and plasma cells produce more IgE as a result. This is similar with the findings of the study, as mice treated with DiNP had higher levels of lymphocytes (Lin et al, 2013). The coadministration of ELA and DiNP, however, mitigated the observed increase.…”
Section: Discussionsupporting
confidence: 91%
“…Eosinophils in the airways are drawn in and stimulated, and plasma cells produce more IgE as a result. This is similar with the findings of the study, as mice treated with DiNP had higher levels of lymphocytes (Lin et al, 2013). The coadministration of ELA and DiNP, however, mitigated the observed increase.…”
Section: Discussionsupporting
confidence: 91%
“…CD274 is a ligand and binds with the receptor PD1, commonly found on T cells, and acts to block T cell activation [ 38 ]. IL2RB binds to ligand IL2, which is involved in T cell-mediated immune responses [ 69 ]. IL7R binds to ligand IL7, and the IL7R signals through the JAK/STAT pathway.…”
Section: Discussionmentioning
confidence: 99%
“…It stimulates the production of IFN-γ, which is the antagonist to Th2-response. There are data proving that IL-2 controls allergic inflammation too, for instance in asthma, where it regulates the differentiation of T-regulators [ 14 , 15 ].…”
Section: Discussionmentioning
confidence: 99%