2024
DOI: 10.1111/omi.12482
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Involvement of PG1037 in the repair of 8‐oxo‐7,8‐dihydroguanine caused by oxidative stress in Porphyromonas gingivalis

Yuetan Dou,
Arunima Mishra,
Hansel M. Fletcher

Abstract: BackgroundThe PG1037 gene is part of the uvrA‐PG1037‐pcrA operon in Porphyromonas gingivalis. It encodes for a protein of unknown function upregulated under hydrogen peroxide (H2O2)‐induced oxidative stress. Bioinformatic analysis shows that PG1037 has a zinc‐finger motif, two peroxidase motifs, and one cytidylate kinase domain. The aim of this study is to characterize further the role of the PG1037 recombinant protein in the unique 8‐oxoG repair system in P. gingivalis.Materials and MethodsPG1037 recombinant … Show more

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