Involvement of phase II enzymes and efflux transporters in the metabolism and absorption of naringin, hesperidin and their aglycones in rats

Guo, Xiao; Cao, Xuedan; Xiugui, Fang; Li, Erhu

doi:10.1080/09637486.2021.2012562

Cited by 9 publications

(7 citation statements)

References 46 publications

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“…The oral bioavailability of naringin in humans has been reported to be only 5–9% [ 26 ]. The lower bioavailability may be closely related to the extensive metabolism of naringin, first-pass elimination, and the exocytosis of metabolites [ 27 ]. Naringin metabolism is a complex process catalyzed by various enzymes [ 21 , 22 , 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Peng,

Qu,

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Peng,

Qu,

et al. 2024

Heliyon

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“…As a result, its characteristics of absorption and bioavailability are highly different from hesperidin . Most previous studies mainly focused on the absorption, metabolism, bioavailability, and bioactivity of hesperidin; − however, there are few studies that investigate or evaluate the absorption and bioactivity of long-term dietary Hes-7-G as a result of its relatively low content in plants. Using a combination of metabolomics, metagenomics, and biological assays, this study identified that long-term dietary intake of Hes-7-G significantly modulated the gut microbiota and BA metabolism after intestinal absorption in mice.…”

Section: Discussionmentioning

confidence: 99%

Multiomics Analyses Reveal That Long-Term Intake of Hesperetin-7-O-glucoside Modulates the Gut Microbiota and Bile Acid Metabolism in Mice

Lei

Chen

et al. 2022

J. Agric. Food Chem.

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Hesperetin-7-O-glucoside (Hes-7-G) is a typical flavonoid monoglucoside, which can be generated from hesperidin with the removal of rhamnose by hydrolysis. Untargeted and targeted metabolomics together with 16S rRNA gene sequencing were employed to explore the exact absorption site of Hes-7-G and its beneficial effect in mice. Intestinal 1 H nuclear magnetic resonance (NMR)-based metabolomics screening showed that Hes-7-G is mainly metabolized in the small intestine of mice, especially the ileum segment. Quantification analysis of bile acids (BAs) in the liver, intestinal tract, feces, and serum of mice suggests that Hes-7-G intake accelerates the processes of biosynthesis and excretion of BAs, thus promoting digestion and lowing hepatic cholesterol and triglyceride. 16S rRNA gene sequencing reveals that Hes-7-G significantly elevates the diversity of the gut microbiota in mice, especially those bacteria associated with BA secondary metabolism. These results demonstrated that long-term dietary Hes-7-G plays beneficial roles in health by modulating the gut bacteria and BA metabolism in mice.

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“…67 NAR is primarily metabolized in the body through phase II metabolism, specifically glucuronidation and sulfation. 68,69 In these processes, NAR is incorporated with glucuronic acid or sulfate moieties, resulting in the production of NAR glucuronides and NAR sulfates, respectively. 61 These metabolites are more water-soluble than NAR itself, making it easier for the body to excrete them.…”

Section: Metabolismmentioning

confidence: 99%

“…Naringin, a glycoside derivative of NAR, can be converted into NAR through hydrolysis by the liver enzyme beta‐glucosidase 67 . NAR is primarily metabolized in the body through phase II metabolism, specifically glucuronidation and sulfation 68,69 . In these processes, NAR is incorporated with glucuronic acid or sulfate moieties, resulting in the production of NAR glucuronides and NAR sulfates, respectively 61 .…”

Section: Overview Of Narmentioning

confidence: 99%

A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes

Zamanian,

Golmohammadi,

Abdullaev

et al. 2024

Cell Biochemistry & Function

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Colorectal cancer (CRC) is a common and highly metastatic cancer affecting people worldwide. Drug resistance and unwanted side effects are some of the limitations of current treatments for CRC. Naringenin (NAR) is a naturally occurring compound found in abundance in various citrus fruits such as oranges, grapefruits, and tomatoes. It possesses a diverse range of pharmacological and biological properties that are beneficial for human health. Numerous studies have highlighted its antioxidant, anticancer, and anti‐inflammatory activities, making it a subject of interest in scientific research. This review provides a comprehensive overview of the effects of NAR on CRC. The study's findings indicated that NAR: (1) interacts with estrogen receptors, (2) regulates the expression of genes related to the p53 signaling pathway, (3) promotes apoptosis by increasing the expression of proapoptotic genes (Bax, caspase9, and p53) and downregulation of the antiapoptotic gene Bcl2, (4) inhibits the activity of enzymes involved in cell survival and proliferation, (5) decreases cyclin D1 levels, (6) reduces the expression of cyclin‐dependent kinases (Cdk4, Cdk6, and Cdk7) and antiapoptotic genes (Bcl2, x‐IAP, and c‐IAP‐2) in CRC cells. In vitro CDK2 binding assay was also performed, showing that the NAR derivatives had better inhibitory activities on CDK2 than NAR. Based on the findings of this study, NAR is a potential therapeutic agent for CRC. Additional pharmacology and pharmacokinetics studies are required to fully elucidate the mechanisms of action of NAR and establish the most suitable dose for subsequent clinical investigations.

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Involvement of phase II enzymes and efflux transporters in the metabolism and absorption of naringin, hesperidin and their aglycones in rats

Cited by 9 publications

References 46 publications

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Regulatory mechanism and therapeutic potentials of naringin against inflammatory disorders

Multiomics Analyses Reveal That Long-Term Intake of Hesperetin-7-O-glucoside Modulates the Gut Microbiota and Bile Acid Metabolism in Mice

A narrative review on therapeutic potential of naringenin in colorectal cancer: Focusing on molecular and biochemical processes

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