Involvement of S100A14 Protein in Cell Invasion by Affecting Expression and Function of Matrix Metalloproteinase (MMP)-2 via p53-dependent Transcriptional Regulation

Chen, Hongyan; Yuan, Yi; Zhang, Chunpeng; Luo, Aiping; Ding, Fang; Ma, Jin; Yang, Shengwen; Tian, Ying; Tong, Tong; Zhan, Qimin; Liu, Zhihua

doi:10.1074/jbc.m111.326975

Cited by 66 publications

(73 citation statements)

References 46 publications

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“…Moreover, S100A14 was significantly associated with clinical outcome of breast cancer patients. Our previous studies showed that S100A14 requires functional p53 to affect MMP2 transcription (12). We also found that S100A14 could be secreted from stably overexpressing S100A14 of EC9706 cells, and low doses of extracellular S100A14 stimulate cell proliferation and promote survival in KYSE180 cells, but a high dose of S100A14 causes apoptosis via the mitochondrial pathway (13).…”

mentioning

confidence: 77%

S100A14, a Member of the EF-hand Calcium-binding Proteins, Is Overexpressed in Breast Cancer and Acts as a Modulator of HER2 Signaling

Chen

Wang³

et al. 2014

Journal of Biological Chemistry

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Background:The role of S100A14 in tumorigenesis and the underlying mechanisms have not been fully understood. Results: S100A14 binds HER2 (human epidermal growth factor receptor 2) and modulates HER2 phosphorylation and HER2-stimulated cell proliferation. Conclusion: S100A14 acts as a functional partner of HER2. Significance: These findings provide mechanistic evidence for S100A14 in breast cancer progression.

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confidence: 77%

S100A14, a Member of the EF-hand Calcium-binding Proteins, Is Overexpressed in Breast Cancer and Acts as a Modulator of HER2 Signaling

Chen

Wang³

et al. 2014

Journal of Biological Chemistry

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“…S100A14 is known to promote esophageal squamous cancer cell motility and invasiveness by regulating the expression and function of MMP2 in a p53-dependent manner (18). S100A14 has also been documented to be regulated by TIMP-1, which promotes tumorigenesis of breast cancer cells (49).…”

Section: Discussionmentioning

confidence: 99%

12-O-Tetradecanoylphorbol-13-acetate Promotes Breast Cancer Cell Motility by Increasing S100A14 Level in a Kruppel-like Transcription Factor 4 (KLF4)-dependent Manner

He¹,

Li²,

Chen

et al. 2014

Journal of Biological Chemistry

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Background:The transcriptional regulation of S100A14 and its underlying mechanism have not been fully elucidated. Results: The activation of S100A14 promoter by KLF4 mediates its up-regulation upon TPA stimulation. Conclusion: S100A14 partly mediates TPA-induced cell motility in a KLF4-dependent manner. Significance: KLF4 plays a significant and previously unrecognized role in regulation of S100A14.

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“…Extracellular S100A4 binds to RAGE, and upregulates MMP-13, MMP-2 and MMP-9 gene expression (19,61), allowing cell invasion and thus promoting metastasis (1,16). Intracellular S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP-2 in a p53-dependent manner (22,62). p53 transrepresses MMP-2 gene expression and thus enables intracellular S100A14 to effect p53 transactivity and stability, resulting in an enhancement of MMP2 gene expression (22).…”

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confidence: 99%

S100 family signaling network and related proteins in pancreatic cancer (Review)

Huang

Jiang

et al. 2014

International Journal of Molecular Medicine

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Abstract. The occurrence and development of pancreatic cancer is a complex process convoluted by multi-pathogenies, multi-stages and multi-factors. S100 proteins are members of the S100 family that regulate multiple cellular pathways related to pancreatic cancer progression and metastasis. S100 proteins have a broad range of intracellular and extracellular functions, including the regulation of protein phosphorylation and enzyme activity, calcium homeostasis and the regulation of cytoskeletal components and transcriptional factors. S100 proteins interact with receptor for advanced glycation end-products (RAGE), p53 and p21, which play a role in the degradation of the extracellular matrix (ECM) and metastasis, and also interact with cytoskeletal proteins and the plasma membrane in pancreatic cancer progression and metastasis. S100A11 and S100P are significant tumor markers for pancreatic cancer and unfavorable predictors for the prognosis of patients who have undergone surgical resection. Recently, S100A2 has been suggested to be a negative prognostic biomarker in pancreatic cancer, and the expression of S100A6 may be an independent prognostic impact factor. The expression of S100A4 and S100P is associated with drug resistance, differentiation, metastasis and clinical outcome. This review summarizes the role and significance of the S100 family signaling network and related proteins in pancreatic cancer.

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Involvement of S100A14 Protein in Cell Invasion by Affecting Expression and Function of Matrix Metalloproteinase (MMP)-2 via p53-dependent Transcriptional Regulation

Cited by 66 publications

References 46 publications

S100A14, a Member of the EF-hand Calcium-binding Proteins, Is Overexpressed in Breast Cancer and Acts as a Modulator of HER2 Signaling

S100A14, a Member of the EF-hand Calcium-binding Proteins, Is Overexpressed in Breast Cancer and Acts as a Modulator of HER2 Signaling

12-O-Tetradecanoylphorbol-13-acetate Promotes Breast Cancer Cell Motility by Increasing S100A14 Level in a Kruppel-like Transcription Factor 4 (KLF4)-dependent Manner

S100 family signaling network and related proteins in pancreatic cancer (Review)

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