Involvement of the central nervous system in non-hodgkin's lymphoma

Law, Ivan P.; Dick, Fred R.; Blom, Johannes; Bergevin, Patrick R.

doi:10.1002/1097-0142(197507)36:1<225::aid-cncr2820360125>3.0.co;2-a

Cited by 111 publications

(14 citation statements)

References 13 publications

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“…Central nervous system involvement (CNS) is not a rare complication during the clinical course of non-Hodgkin's lymphoma (NHL) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Recently improved therapies for NHL have resulted in longer survival periods, which may increase the likelihood of developing CNS involvement.…”

Section: Introductionmentioning

confidence: 99%

Predictive Factors for Central Nervous System Involvement in Non-Hodgkin's Lymphoma: Significance of Very High Serum LDH Concentrations

Tomita

Kodama

Sakai

et al. 2000

Leukemia & Lymphoma

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Factors predictive for central nervous system (CNS) involvement at presentation were investigated in 152 patients with non-Hodgkin's lymphoma (NHL) except for lymphoblastic cell lymphoma and small noncleaved cell lymphoma. Twelve patients developed CNS involvement during their disease course. The incidence was 7.9% of all the patients studied and 17.0% of the patients with serum LDH concentration > or = two times the upper limit of normal (2N). By univariate analysis, stage IV disease (P = .023), a serum LDH concentration > or = 2 N (P = .009), and bone marrow involvement (P = .016) were risk factors for CNS involvement. Multivariate logistic regression analysis identified a serum LDH concentration > or = 2 N (P = .032) as an independent predictor for CNS involvement. All 12 patients who developed CNS involvement were among the 126 patients with diffuse lymphoma, whereas none of the 17 patients with follicular lymphoma developed CNS involvement, although the difference was not statistically significant. The median survival of the patients with CNS involvement was only 4.5 months. We conclude that a serum LDH concentration > or = 2N at presentation is a significant predictive factor for CNS involvement for NHL patients without lymphoblastic lymphoma and small noncleaved cell lymphoma. Therefore, we would suggest that CNS prophylaxis should be considered for patients with a serum LDH concentration > or = 2N at presentation and diffuse lymphoma once a complete remission is achieved.

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Section: Introductionmentioning

confidence: 99%

Predictive Factors for Central Nervous System Involvement in Non-Hodgkin's Lymphoma: Significance of Very High Serum LDH Concentrations

Tomita

Kodama

Sakai

et al. 2000

Leukemia & Lymphoma

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“…3,5,6) Although we did not examine the cerebrospinal fluid of our patient, the collections of necrotic and denatured tumor cell-like scars in the arachnoid, and the absence of tumor cells in the aneurysm wall suggest that these aneurysms developed via intrathecal dissemination.…”

Section: Discussionmentioning

confidence: 85%

“…7) The most common neuropathological findings in patients with metastasis are infiltration of the leptomeninges, nerve roots, perivascular space, or brain parenchyma, which can result in both focal and generalized symptoms. 6,10) We report an extremely rare case of ruptured aneurysms on the distal middle cerebral artery (MCA) that may be attributable to mucosa-associated lymphoid tissue (MALT) lymphoma. The patient was successfully treated with vasoconstructive surgery using a superficial temporal artery (STA) graft.…”

Section: Introductionmentioning

confidence: 99%

Arterial Graft to Treat Ruptured Distal Middle Cerebral Artery Aneurysms in a Patient With Mucosa-Associated Lymphoid Tissue Lymphoma

Hasegawa

Morioka

Makino

et al. 2012

Neurol. Med. Chir.(Tokyo)

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A 60-year-old man was admitted to our hospital with sudden onset of motor aphasia, Gerstmann syndrome, and incomplete right hemiparesis one week after administration of chemotherapy for mucosaassociated lymphoid tissue (MALT) lymphoma. Computed tomography showed an intracerebral hematoma in the left subcortical area. Cerebral angiography revealed 2 aneurysms on the distal middle cerebral artery (MCA) that increased in size in the course of 2 weeks. The aneurysms were excised and a bypass placed using a superficial temporal artery (STA) graft. Histological study showed no bacteria, infiltration of inflammatory cells, or lymphoma cells in the aneurysm wall. The chemotherapy against MALT lymphoma was highly effective, so we presumed that the lymphoma cells had disappeared. The source of the distal MCA aneurysms was thought to be oncotic. Distal MCA aneurysms caused by MALT lymphoma are extremely rare. Surgical reconstruction using the STA may be effective in patients with ruptured distal MCA aneurysms if the wall is intact.

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“…In 5 of our own cases, lymphomatous infiltration of the bone marrow was seen at presentation. Law et al (1975) have suggested that lymphoma with retroperitoneal involvement might have predilection for CNS relapse, as was the situation with Case 1. One of our patients (Case 5), had testicular swelling as an initial symptom and Wolley et al (1976) proposed that that type of clinical presentation might predispose to CNS disease later.…”

Section: Discussionmentioning

confidence: 95%

The need for prophylactic treatment to the central nervous system in patients with aggressive non-Hodgkin’s lymphoma

Hawkey

Toghill

1983

Postgraduate Medical Journal

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SummaryDuring 2 years, 6 out of 34 patients presenting with newly diagnosed non-Hodgkin's lymphoma developed central nervous system (CNS) complications. All were male and had diffuse, undifferentiated lymphomas. In all 6 patients, CNS disease developed during, or shortly after, treatment. We suggest that a group at high risk from these complications can be identified and should be considered for a trial of prophylaxis.

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Involvement of the central nervous system in non-hodgkin's lymphoma

Cited by 111 publications

References 13 publications

Predictive Factors for Central Nervous System Involvement in Non-Hodgkin's Lymphoma: Significance of Very High Serum LDH Concentrations

Predictive Factors for Central Nervous System Involvement in Non-Hodgkin's Lymphoma: Significance of Very High Serum LDH Concentrations

Arterial Graft to Treat Ruptured Distal Middle Cerebral Artery Aneurysms in a Patient With Mucosa-Associated Lymphoid Tissue Lymphoma

The need for prophylactic treatment to the central nervous system in patients with aggressive non-Hodgkin’s lymphoma

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