Involvement of the JNK signaling in granular corneal dystrophy by modulating TGF-β-induced TGFBI expression and corneal fibroblast apoptosis

Increased Serum Expression of Inflammatory Cytokines may Serve as Potential Diagnostic Biomarker for Bilirubin Encephalopathy

“…Moreover, it has been reported that inhibition of NF-κB inflammatory signaling exerts neuroprotective functions in BE rat models ( 9 ). IL-1β ( 11 , 12 ) and TGF-β ( 13 - 15 ) are two common cytokines secreted by immune cells; they were found to be upregulated in many immune diseases ( 11 , 15 ); however, their expression patterns, as well as their clinical significance in BE, have not been discussed thus far. In the current study, we found that both IL-1β and TGF-β expression levels were markedly increased in the serum of BE patients compared with those of healthy controls.…”

The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time

“…Anisomycin is a key JNK activator that is known for its ability to increase levels of phospho-JNK (p-JNK) (Li et al, 2012). Anisomycin was widely used as an agonist for p38 mitogenactivated protein kinase (p38 MAPK) and Jun-NH2 terminal kinase (JNK), as it can induce apoptosis through the activation of the p38 MAPK and JNK signaling pathways (Nie et al, 2020). Several reports suggest that JNK can be used to study the formation of primary tumors as a tumor suppressor, where JNK serves an inhibitory role by mediating the activation of apoptosis (Reno et al, 2009).…”