Iodide Kinetic Studies in Newborns and Infants

Ponchon, G.; Beckers, Christian; Visscher, M. De

doi:10.1210/jcem-26-12-1392

Cited by 22 publications

(8 citation statements)

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“…The authors also calculated 24 hr accumulation rates of dietary (stable) iodide in the thyroid gland of 1.0 and 0.65 μ g/kg/day for adolescents and adults. Ponchon et al investigated the iodide kinetics in 21 newborns and infants [19], and pharmacokinetic parameters were compared to values reported earlier for adolescents and adults [13]. The thyroidal clearance of iodide, expressed in units of mL/min/kg, was found to decrease with increasing age.…”

Section: Aspects Of the Hpt Axis In Adults And Childrenmentioning

confidence: 99%

“…Similar to the thyroidal clearance of iodide, the renal clearance of iodide was also found to be higher in the young, particularly between the age of 3 weeks to 6 months [19]. When normalized for body weight, the young excrete iodide in urine at a greater rate than adults, which is inconsistent with maturation of glomerular filtration.…”

Section: Aspects Of the Hpt Axis In Adults And Childrenmentioning

confidence: 99%

“…The mean infant iodide blood concentration was 15.7 μ g/L (range of 12.5 to 21.7 μ g/L) compared to adult mean serum iodide concentration of 110 μ g/L (range of 14.1 to 812 μ g/L) [57]. During the first year of life for infants in Belgium, the serum iodide levels were 2.2 to 6 μ g/L and for adults, near 1 μ g/L [19]. …”

Section: Aspects Of the Hpt Axis In Adults And Childrenmentioning

confidence: 99%

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The Hypothalamic-Pituitary-Thyroid Axis in Infants and Children: Protection from Radioiodines

Fisher

Yang

Harris

et al. 2014

Journal of Thyroid Research

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Potassium iodide (KI) is recommended as an emergency treatment for exposure to radioiodines, most commonly associated with nuclear detonation or mishaps at nuclear power plants. Protecting the thyroid gland of infants and children remains a priority because of increased incidence of thyroid cancer in the young exposed to radioiodines (such as 131I and 133I). There is a lack of clinical studies for KI and radioiodines in children or infants to draw definitive conclusions about the effectiveness and safety of KI administration in the young. In this paper, we compare functional aspects of the hypothalamic-pituitary-thyroid (HPT) axis in the young and adults and review the limited studies of KI in children. The HPT axis in the infant and child is hyperactive and therefore will respond less effectively to KI treatment compared to adults. Research on the safety and efficacy of KI in infants and children is needed.

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Section: Aspects Of the Hpt Axis In Adults And Childrenmentioning

confidence: 99%

Section: Aspects Of the Hpt Axis In Adults And Childrenmentioning

confidence: 99%

Section: Aspects Of the Hpt Axis In Adults And Childrenmentioning

confidence: 99%

See 1 more Smart Citation

The Hypothalamic-Pituitary-Thyroid Axis in Infants and Children: Protection from Radioiodines

Fisher

Yang

Harris

et al. 2014

Journal of Thyroid Research

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“…Further, a deterministic algorithm was used as described in [18], which allows a growing number of target cells for children. The increase in thyroid cells after the birth of the child is rather complicated as the activity of the thyroid and the related specific mass changes significantly during childhood [29] and is, for example, dependent on the average iodine intake [30]. For the model calculations it was assumed that the number of target cells in the thyroid increased with the thyroid mass.…”

Section: Two-mutation Carcinogenesis Modelmentioning

confidence: 99%

“…For the model calculations it was assumed that the number of target cells in the thyroid increased with the thyroid mass. Several sources of the development of the thyroid during childhood are available [24,27,30,31,32]. Primarily based on the combined data in [27], the following relationship was used for the age-dependent number of target cells for thyroid cancer:…”

Section: Two-mutation Carcinogenesis Modelmentioning

confidence: 99%

Analysis of thyroid cancer data from the Ukraine after ’Chernobyl' using a two-mutation carcinogenesis model

Leenhouts¹,

Brugmans²,

Chadwick³

2000

Radiation and Environmental Biophysics

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The thyroid cancer data of children in the northern regions of the Ukraine after the reactor accident at Chernobyl were combined with thyroid dose measurements in the same regions and analysed using a two-mutation carcinogenesis model. The best fit was obtained for radiation acting as an initiating agent, i.e. on the first mutation of the model. The observed relatively high increase of thyroid cancer incidence after 1990 in children exposed to radiation released after the reactor accident could be ascribed to the high thyroid doses and the relatively low background thyroid cancer incidence in children. The maximum annual incidence is predicted to occur fairly soon after the reactor accident, i.e. about 10 years. For adults, the predicted relative increase of annual thyroid cancers is much lower than for children younger than 20 years. The modelling results are used to derive risk estimates for radiation-induced thyroid cancer. These risk estimates are dependent on age at exposure, follow-up time and the background thyroid cancer incidence. The calculated excess absolute risk for a population of all ages is about one-third of that currently used by ICRP, but for children the calculated absolute risks are about a factor of 3 higher than derived in other epidemiological studies. The model results indicate that the excess absolute radiation risk per unit dose for children is about the same as or a little lower than that for adults.

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