Iodinated Contrast Media Can Induce Long-Lasting Oxidative Stress in Hemodialysis Patients

Abstract

PurposeDue to their comorbidities, dialysis patients have many chances to undergo radiologic procedures using iodinated contrast media. We aimed to assess time-sequenced blood oxidative stress level after contrast exposure in hemodialysis (HD) patients compared to those in the non-dialysis population.Materials and MethodsWe included 21 anuric HD patients [HD-coronary angiography (CAG) group] and 23 persons with normal renal function (nonHD-CAG group) scheduled for CAG, and assessed 4 oxidative stress markers [advanced oxidation protein products (AOPP); catalase; 8-hydroxydeoxyguanosine; and malondialdehyde] before and after CAG, and subsequently up to 28 days.ResultsIn the nonHD-CAG group, only AOPP increased immediately after CAG and returned to baseline within one day. However, in the HD-CAG group, all four oxidative stress markers were significantly increased starting one day after CAG, and remained elevated longer than those in the nonHD-CAG group. Especially, AOPP level remained elevated for a month after contrast exposure.ConclusionOur study showed that iodinated contrast media induces severe and prolonged oxidative stress in HD patients.

NMR-Based Metabolomic Analysis on the Protective Effects of Apolipoprotein A-I Mimetic Peptide against Contrast Media-Induced Endothelial Dysfunction

“…Iodixanol induces disorders in five metabolic pathways related to oxidative stress, including glutamine and glutamate metabolism; alanine, aspartate and glutamate metabolism; glycine, serine and threonine metabolism; glutathione metabolism; taurine and hypotaurine metabolism. Previous work reported that prolonged and severe oxidative stress was observed in hemodialysis patients with CM injections [ 22 ]. In this study, we found that several antioxidative molecules (glutathione, creatine, and fumarate) were decreased in iodixanol-treated HUVECs.…”

An evaluation of the antioxidant properties of iodinated radiographic contrast media: An in vitro study

“…Other authors showed that iodinated radiographic contrast media caused severe and prolonged oxidative stress in hemodialysis patients. Moreover, iodinated radiographic contrast media increased advanced oxidation protein products (AOPP), catalase, 8-hydroxydeoxyguanosine, and malondialdehyde, which are oxidative stress markers, in hemodialysis patients [ 34 ].…”