Ion imprinted beads embedded cryogels for <i>in vitro</i> removal of iron from β‐thalassemic human plasma

Ergün, Bahar; Baydemir, Gözde; Andaç, Müge; Yavuz, Handan; Deni̇zli̇, Adil

doi:10.1002/app.35537

Cited by 21 publications

(12 citation statements)

References 61 publications

(87 reference statements)

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“…They measured the surface area, swelling degree and maximum adsorption capacity of composite cryogel as 76.8 m 2 /g, 7.7 g H 2 O/g cryogel and 2.23 mg/g. They also calculated the relative selectivity of composite cryogel towards Fe 3+ ions and found that it was 135.0, 61.4, and 57.0 times greater than Ni 2+ , Zn 2+ , and Fe 2+ ions, respectively [86].…”

Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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Supermacroporous gels, called cryogels, are unique scaffolds that can be prepared by polymerization of monomer solution under sub-zero temperatures. They are widely used in many applications and have significant potential biomaterials, especially for biomedical applications due to their inherent interconnected supermacroporous structures and easy formation of composite polymers in comparison to other porous polymer synthesis techniques. This review highlights the fundamentals of supermacroporous cryogels and composite cryogels, and then comprehensively summarizes recent studies in preparation, functionalization, and utilization with mechanical, biological and physicochemical features, according to the biomedical applications. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable supermacroporous composite cryogels.

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Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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“…All biomaterials have to meet the certain criteria before use for living systems. Depending on desired end use the blood compatibility, tissue compatibility, carcinogenicity, toxicity and mechanical stability tests must be performed using developed bioma-terials (Denizli and Piskin 1995, Denizli 1999, Ergün et al 2012). If a material contact with blood, firstly the small molecules are floated on surface (i.e.…”

Section: Hp Removal Studies From Human Plasmamentioning

confidence: 99%

Heparin removal from human plasma using molecular imprinted cryogels

Baydemir

Deni̇zli̇

2014

Artificial Cells, Nanomedicine, and Biotechnology

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In this study, heparin-imprinted poly(hydroxyethyl methacrylate-N-[(3-dimethylamino)-propyl] methacrylamide) cryogel column (HpMIP) was synthesized for removal of Hp from human plasma using molecular imprinting technique. Hp removal studies were performed from both aqueous solution and human plasma. Selectivity studies were performed using fast protein liquid chromatography (FPLC) system. The obtained results showed that the HpMIP column can remove Hp from both aqueous solutions and human plasma samples selectively. Ninety per cent of Hp was removed from 28 U/mL of human plasma samples successfully. Non-imprinted cryogel column (NIP) and plane PHEMA column were also synthesized to compare selectivity and non-specific adsorption properties.

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“…As a whole, this is useless presentation of the textural characteristics of the cryogels. Cryogels with molecular-imprinted polymers have attracted increased attention because of significant enhancement of the selectivity of the materials used as adsorbents [234,243]. Additionally, functionalisation of cryogels can be used for the same purposes.…”

Section: Diffusion Of Small Molecules Polymers Proteins and Cells Wmentioning

confidence: 99%

Cryogels: Morphological, structural and adsorption characterisation

Gun'ko

Savina

Mikhalovsky

2013

Advances in Colloid and Interface Science

287

205

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*Graphical Abstract (for review)Cryotripic gelation technique allows the synthesis of solid and soft macroporous gels Textural characterisation of cryogel in native superhydrated state with noninvasive methods Adsorption and diffusion characteristics of macroporous cryogels with respect to macromolecules and cells Theoretical modelling of adsorption from aqueous media *Highlights (for review) Please find the revised manuscript entitled "Cryogels: morphological, structural and adsorption characterisation" by Vladimir M. Gun'ko, Irina N. Savina, Sergey V. Mikhalovsky to re-consider for publication in the "Advances in Colloid and Interface Science"The paper was completely edited and changed according to reviewers comments.Sincerely yours, Prof. V. M. Gun'koCover Letter ABSTRACTExperimental results on polymer, protein, and composite cryogels and data treatment methods used for morphological, textural, structural, adsorption and diffusion characterisation of the materials are analysed and compared. Treatment of microscopic images with specific software gives quantitative structural information on both native cryogels and freeze-dried materials that is useful to analyse the drying effects on their structure. A combination of cryoporometry, relaxometry, thermoporometry, small angle X-ray scattering (SAXS), equilibrium and kinetic adsorption of low and high-molecular weight compounds, diffusion breakthrough of macromolecules within macroporous cryogel membranes, studying interactions of cells with cryogels provides a consistent and comprehensive picture of textural, structural and adsorption properties of a variety of cryogels. This analysis allows us to establish certain regularities in the cryogel properties related to narrow (diameter 0.4 < d < 2 nm), middle (2 < d < 50 nm) and broad (50 < d < 100 nm) nanopores, micropores (100 nm < d < 100 m) and macropores (d > 100 m) with boundary sizes within modified life science pore classification. Particular attention is paid to water bound in cryogels in native superhydrated or freeze-dried states. At least, five states of water -free unbound, weakly bound (changes in the Gibbs free energy G < 0.5-0.8 kJ/mol) and strongly bound (G > 0.8 kJ/mol), and weakly associated (chemical shift of the proton resonance  H = 1-2 ppm) and strongly associated ( H = 3-6 ppm) waters can be distinguished in hydrated cryogels using 1 H NMR, DSC, TSDC, TG and other methods. Different software for image treatment or developed to analyse the data obtained with the adsorption, diffusion, SAXS, cryoporometry and thermoporometry methods and based on regularisation algorithms is analysed and used for the quantitative morphological, structural and adsorption characterisation of individual and composite cryogels, including polymers filled with solid nano-or microparticles.

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Ion imprinted beads embedded cryogels for in vitro removal of iron from β‐thalassemic human plasma

Cited by 21 publications

References 61 publications

Supermacroporous Composite Cryogels in Biomedical Applications

Supermacroporous Composite Cryogels in Biomedical Applications

Heparin removal from human plasma using molecular imprinted cryogels

Cryogels: Morphological, structural and adsorption characterisation

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