Ion isolation and collision-induced dissociation in a 0.5mm ro cylindrical ion trap

Jesseph, A.V.; Fox, James D.; Verbeck, Guido F.

doi:10.1016/j.ijms.2010.03.008

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…Nonetheless, many small analyzers have been fabricated using this method. Cylindrical ion traps of radius 2.5 mm , and 0.50 mm − have been fabricated from stainless steel with either glass ceramic or Teflon insulating spacers. Serial as well as parallel CIT arrays have been similarly produced. ,, Lammert et al have constructed a toroidal ion trap of 2 mm radius and another with a 5.91 mm radius .…”

Section: Mems and Other Alternative Fabrication Methodsmentioning

confidence: 99%

Miniature and Fieldable Mass Spectrometers: Recent Advances

et al. 2015

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Section: Mems and Other Alternative Fabrication Methodsmentioning

confidence: 99%

Miniature and Fieldable Mass Spectrometers: Recent Advances

et al. 2015

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“…A number of miniaturization efforts have focused on the CIT due to its simplicity. [21][22][23][24] Arrays of CITs have also been developed in order to increase the number of trapped ions. [25][26][27] The physical dimensions of traps in an array must be as identical as possible so that each ion ejects the same m/z at the same time.…”

Section: Types Of Traps Approaches To Miniaturizationmentioning

confidence: 99%

How far can ion trap miniaturization go? Parameter scaling and space‐charge limits for very small cylindrical ion traps

Tian,

Higgs,

et al. 2014

J. Mass Spectrom.

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A broad effort is underway to make radiofrequency (RF) ion trap mass spectrometers small enough for portable chemical analysis. A variety of trap geometries and fabrication approaches are under development from several research groups. A common issue is the reduced trapping capacity in smaller traps, with the associated reduction in sensitivity. This article explores the key variables that scale with trap size including RF voltage, frequency, electrical capacitance, power and pseudopotential well depth. High-field electric breakdown constrains the maximum RF voltages used in smaller ion traps. Simulations show the effects of space charge and the limits of trapping capacity as a function of trap dimensions for cylindrical ion traps down to the micrometer level. RF amplitudes that scale as the 1/3, 1/2 and 2/3 power of trap radius, r0, were studied. At a fixed level of performance, the number of analyzable ions scales as r0(n), with n ranging from 1.55 to 1.75 depending on the choice of voltage scaling. The implications for miniaturized ion trap mass spectrometry are discussed.

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“…In contrast to TOFs, linear quadrupoles, and magnetic sectors [19], ion traps enjoy the ability to perform tandem mass spectrometry with a single mass analyzer [20]. The simplified geometry of a cylindrical ion trap in comparison to 3D ion traps has led to a significant research investment in the miniaturization of ion traps [21][22][23][24][25][26] and micro-fabricated ion trap arrays [27][28][29]. Lammert [30,31] and Austin [32][33][34] have studied toroidal ion traps of various geometries in an attempt to expand the quantitative dynamic range of ion traps in miniature and portable instruments.…”

Section: Introductionmentioning

confidence: 99%

Performance Evaluation of a Loeb-Eiber Mass Filter at 1 Torr

Hoffmann

Feng

Pedder³

et al. 2014

J. Am. Soc. Mass Spectrom.

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Abstract. The Loeb-Eiber mass filter is best operated at relatively high pressures-such as 1 Torr-where collisional dampening of ions up to the mass filter thermalizes the ions' kinetic energy, which is a requirement for effective filtering. The inter-electrode gaps of~8 μm require rf amplitudes on the order of 0-5 V p-p at approximately 50 MHz to achieve mass filtering up to m/z 40. Mass filtering between the 25-μm diameter wires, therefore, takes place on time frames less than the collision frequency at~1 Torr. The low power and high pressure capabilities of the Loeb-Eiber mass filter make it ideally suited for miniaturization, where power and space are a premium. In the present work, a Loeb-Eiber mass filter was constructed using commercial silicon-on-insulator (SOI) microfabrication techniques. Ions transmitting through the chip-based Loeb-Eiber mass filter were characterized in real time using a traditional linear quadrupole mass analyzer in series with the Loeb-Eiber mass filter. The new hybrid instrument has enabled us to verify several important claims regarding the operation of the Loeb-Eiber mass filter: (1) that ions can be effectively filtered at~1 Torr, (2) that for ions of a fixed mass-to-charge ratio, the ion transmission current decreases linearly with increasing rf amplitude on the Loeb-Eiber mass filter, (3) that the cutoff voltage at which all ions of a particular m/z value are effectively blocked is linearly related to mass-to-charge, and (4) that square waveforms can filter ions more effectively than sinusoidal waveforms for a given peak-to-peak rf amplitude.

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Ion isolation and collision-induced dissociation in a 0.5mm ro cylindrical ion trap

Cited by 7 publications

References 23 publications

Miniature and Fieldable Mass Spectrometers: Recent Advances

Miniature and Fieldable Mass Spectrometers: Recent Advances

How far can ion trap miniaturization go? Parameter scaling and space‐charge limits for very small cylindrical ion traps

Performance Evaluation of a Loeb-Eiber Mass Filter at 1 Torr

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