Ion Receptors

Leoni, Luca; Cort, Antonella Dalla; Biedermann, Frank; Kubik, Stefan

doi:10.1002/9783527814923.ch6

Cited by 7 publications

(10 citation statements)

References 153 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several groups have mastered the design of inorganic anion binders, and their contributions were summarized in a recent book section. 1133 Some representative examples of high-affinity anion binders are the bambus[n]urils 1058,1134−1140 (Sindelar group), biotin[n]urils 1141−1143 (Pittelkow group), cyclopeptides, 1144−1151 (Kubik group) and anion binding rotaxanes 1152−1156 (Beer group). In the spirit of this review, we briefly discuss those anion binding systems that provide an optical response to anion binding and thus can be used as chemosensors (see also Table 38).…”

Section: Chemosensors For Inorganic Anionsmentioning

confidence: 99%

“…Several groups have mastered the design of inorganic anion binders, and their contributions were summarized in a recent book section . Some representative examples of high-affinity anion binders are the bambus[ n ]urils ,− (Sindelar group), biotin[ n ]urils − (Pittelkow group), cyclopeptides, − (Kubik group) and anion binding rotaxanes − (Beer group).…”

Section: Inorganic Anionsmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

Self Cite

View full text Add to dashboard Cite

Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, and fast-responding sensors that are applicable in biofluids (urine, blood, and saliva). Particularly, the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions is highly desirable due to a lack of suitable biosensors. In addition, the monitoring and analysis of metabolic and signaling networks in cells and organisms by optical probes and chemosensors is becoming increasingly important in molecular biology and medicine. Thus, new perspectives for personalized diagnostics, theranostics, and biochemical/ medical research will be unlocked when standing limitations of artificial binders and receptors are overcome. In this review, we survey synthetic sensing systems that have promising (future) application potential for the detection of small molecules, cations, and anions in aqueous media and biofluids. Special attention was given to sensing systems that provide a readily measurable optical signal through dynamic covalent chemistry, supramolecular host− guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable the reader to evaluate the current performance of molecular probes, chemosensors, and nanosensors in terms of sensitivity and selectivity with respect to practical requirement, and thereby inspiring new ideas for the development of further advanced systems.

show abstract

Section: Chemosensors For Inorganic Anionsmentioning

confidence: 99%

Section: Inorganic Anionsmentioning

confidence: 99%

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…In these, affinity determinations require host–guest titration experiments in which the ratio of host to guest is varied as a dependent variable is measured. Since in most cases such determinations involve the binding of anions by polycationic hosts, , or the binding of cations to polyanionic hosts, , the ionic strength ( I ) of the solution changes during titration. Do these changes in I lead to significant changes in screening?…”

Section: Introductionmentioning

confidence: 99%

Buffer and Salt Effects in Aqueous Host–Guest Systems: Screening, Competitive Binding, or Both?

Jordan¹,

Ashbaugh

Mague

et al. 2021

J. Am. Chem. Soc.

View full text Add to dashboard Cite

There are many open questions regarding the supramolecular properties of ions in water, a fact that has ramifications within any field of study involving buffered solutions. Indeed, as Pielak has noted (Buffers, Especially the Good Kind, Biochemistry, 2021, in press. DOI:10.1021/acs.biochem.1c00200) buffers were conceived of with little regard to their supramolecular properties. But there is a difficulty here; the mathematical models supramolecular chemists use for affinity determinations do not account for screening. As a result, there is uncertainty as to the magnitude of any screening effect and how this compares to competitive salt/buffer binding. Here we use a tetra-cation cavitand to compare halide affinities obtained using a traditional unscreened model and a screened (Debye–Hückel) model. The rule of thumb that emerges is that if ionic strength is changed by >1 order of magnitudeeither during a titration or if a comparison is sought between two different buffered solutionsscreening should be considered. We also build a competitive mathematical model showing that binding attenuation in buffer is largely due to competitive binding to the host by said buffer. For the system at hand, we find that the effect of competition is approximately twice that of the effect of screening (∼RT at 25 °C). Thus, for strong binders it is less important to account for screening than it is to account for competitive complexation, but for weaker binders both effects should be considered. We anticipate these results will help supramolecular chemists unravel the properties of buffers and so help guide studies of biomacromolecules.

show abstract

“…Different strategies can be envisaged to transfer molecular receptors into water. The most commonly encountered is the grafting of hydrophilic moieties onto the receptor, as shown in recent reviews devoted to water-soluble macrocyclic synthetic receptors. − This however requires additional synthesis steps and careful design, as the hydrophilic groups must not interfere with the binding event. A few examples of macrocyclic receptors have been reported to complex ammoniums in water, but none of these show any selectivity toward primary ammonium ions.…”

Section: Introductionmentioning

confidence: 99%

Specific Binding of Primary Ammoniums in Aqueous Media by Homooxacalixarenes Incorporated into Micelles

et al. 2022

View full text Add to dashboard Cite

The development of artificial receptors for efficient recognition of analytes in water is a challenging task. Homooxacalix[3]arene-based receptor 1, which is selective toward primary ammoniums in organic solvents, was transferred into water following two different strategies: direct solubilization and micellar incorporation. Extensive 1H NMR studies showed that recognition of ammoniums is only observed in the case of micellar incorporation, highlighting the beneficial effect of the microenvironment of the micellar core. The selectivity of the system for primary ammoniums over secondary and tertiary ones was also maintained. The hydrophobic effect plays an important role in the recognition properties, which are counterion-dependent due to the energy penalty for the dissociation of certain ammonium salts in the apolar micellar core. This study shows that the straightforward self-assembly process used for the encapsulation of artificial receptors in micelles is an efficient strategy for developing water-soluble nanosized supramolecular recognition systems.

show abstract

Ion Receptors

Cited by 7 publications

References 153 publications

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

Buffer and Salt Effects in Aqueous Host–Guest Systems: Screening, Competitive Binding, or Both?

Specific Binding of Primary Ammoniums in Aqueous Media by Homooxacalixarenes Incorporated into Micelles

Contact Info

Product

Resources

About