Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques

Abstract

New ranitidine hydrochloride (RaCl)-selective electrodes of the conventional polymer membrane type are described. They are based on incorporation of ranitidine-tetraphenylborate (Ra-TPB) ion-pair or ranitidine-phosphotungstate (Ra-PT) ion-associate in a poly(vinyl chloride) (PVC) membrane plasticized with dioctylphthalate (DOP) or dibutylphthalate (DBP). The electrodes are fully characterized in terms of the membrane composition, solution temperature, and pH. The sensors showed fast and stable responses. Nernstian response was found over the concentration range of 2.0 × 10 -5 M to 1.0 × 10 -2 M and 1.0 × 10 -5 M to 1.0 × 10 -2 M in the case of Ra-TPB electrode and over the range of 1.03 × 10 -5 M to 1.00 × 10 -2 M and 1.0 × 10 -5 M to 1.0 × 10 -2 M in the case of Ra-PT electrode for batch and FIA systems, respectively. The electrodes exhibit good selectivity for RaCl with respect to a large number of common ions, sugars, amino acids, and components other than ranitidine hydrochloride of the investigated mixed drugs. The electrodes have been applied to the potentiometric determination of RaCl in pure solutions and in pharmaceutical preparations under batch and flow injection conditions with a lower detection limit of 1.26 × 10 -5 M and 5.62 × 10 -6 M at 25 ± 1˚C. An average recovery of 100.91% and 100.42% with a relative standard deviation of 0.72% and 0.53% has been achieved.

Instrumental analysis of some anti-ulcer drugs in different matrices

“…[28] A simple capillary zone electrophoresis method was described for the simultaneous determination of ranitidine. [29] Issa et al, [30] presented ion-selective electrodes for potentiometric determination of ranitidine HCl applying batch and flow injection analysis techniques.…”

Spectrophotometric method for determination of ranitidine hydrochloride in bulk and in pharmaceutical preparation using ninhydrin

“…Several methods have been used for determination of ranitidine hydrochloride in pharmaceutical preparations such as proton magnetic resonance spectroscopy [4], near-infrared reflectance spectrometry [5], scintillation proximity assay [6], flow injection analysis [7], cyclic voltammetry [8,9], differential pulse polarography [10], capillary electrophoresis [11,12], liquid chromatography [13], gas chromatography [14] and high-performance liquid chromatography [15,16]. All the previous methods need sophisticated and advanced instruments with expensive reagents and a lot of experimental steps will be made to complete the analysis, because of these reasons; we prefer to use the spectrophotometric method for determination of ranitidine hydrochloride.…”

Simultaneous Determination of Ranitidine and Metronidazole at Poly(thionine) Modified Anodized Glassy Carbon Electrode

“…1,2) Quantitative detection of RT and MT is difficult and crucial for the bioanalysis in biological fluids and drug formulation due to the need to selectively remove the interferents such as proteins. Various methods such as; spectrophotometry, 5) atomic absorption spectrometry, 6) ion selective electrodes, 7) fluorimetric method, 8) near i n f r a r ed r e f l e c t a n c e s p e c t r o m e t r y, 9 ) a n d chromatography 2) have been used for the determination of RT and MT. However, lack of selectivity has restricted the application of these methods for pharmacokinetic studies in pharmaceutical and biological samples.…”