Ion-selective membrane electrodes for the determination of the muscle relaxants pancuronium, tubocurarine, gallamine and succinylcholine

Aubeck, Ralph; Bräuchle, Christoph; Hampp, Norbert

doi:10.1016/s0003-2670(00)80566-8

Cited by 25 publications

(12 citation statements)

References 16 publications

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“…This interest is con¯rmed by numerous works on ionselective electrodes sensitive to ionic substances used in pharmaceuticals e.g. [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Analytical applications of electrode sensitive to labetalol in pharmaceuticals

et al. 2003

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The analytical properties of an ion-selective electrode sensitive to labetalol with a liquid membrane, based on ion-pair complexes with sodium tetraphenylborate (TPBNa + ) are described. The studied electrode can be used for the determination of labetalol hydrochloride as a protonated form of labetalol in pharmaceuticals. The calibration curve, e.g. EMF=f(pC LabHC l ) is linear in the range from 10 ¡5 to 10 ¡2 mol L ¡1 with a correlation coe¯cient of 0.9992 and slope of 61.13 mV/decade, which is close to the Nernstian slope. The detection limit of the examined electrode is 7.20£10 ¡6 mol L ¡1 . The in®uence of pH of the tested solutions on the formulation of the electrode is not as considerable since the electrode works correctly in the pH range 3.0-8.0. The main attributes of the developed electrode are: stability, good reproducibility of EMF and short response time, close to 30 seconds depending on labetalol concentration in the solution. The electrode shows good selectivity for many inorganic ions. The selectivity for drug cations is weaker due to the structural similarity of the interfering cations to labetalol. The results of labetalol determination using direct potentiometry in drugs such as Pressocard (Polpharma) and Trandate (GlaxoWellcome) were compatible with the quantity of labetalol declared by the manufacturer, and with parallel UV spectrophotometric and HPLC determinations.

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“…This interest is con¯rmed by numerous works on ionselective electrodes sensitive to ionic substances used in pharmaceuticals e.g. [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Analytical applications of electrode sensitive to labetalol in pharmaceuticals

et al. 2003

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“…24 The response time of the investigated electrodes was calculated on the basis of this definition. It was found to be within the typical range for macroscopic ion-selective electrode, 25 i.e., the electrodes exhibit fast dynamic instantaneous response time in the order of 10 -20 s. It was found that the response time increases with the increase in the soaking time, due to some leaching of the ion-exchanger into the bathing solution.…”

Section: Response Time Of the Electrodesmentioning

confidence: 69%

Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques

2005

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New ranitidine hydrochloride (RaCl)-selective electrodes of the conventional polymer membrane type are described. They are based on incorporation of ranitidine-tetraphenylborate (Ra-TPB) ion-pair or ranitidine-phosphotungstate (Ra-PT) ion-associate in a poly(vinyl chloride) (PVC) membrane plasticized with dioctylphthalate (DOP) or dibutylphthalate (DBP). The electrodes are fully characterized in terms of the membrane composition, solution temperature, and pH. The sensors showed fast and stable responses. Nernstian response was found over the concentration range of 2.0 × 10 -5 M to 1.0 × 10 -2 M and 1.0 × 10 -5 M to 1.0 × 10 -2 M in the case of Ra-TPB electrode and over the range of 1.03 × 10 -5 M to 1.00 × 10 -2 M and 1.0 × 10 -5 M to 1.0 × 10 -2 M in the case of Ra-PT electrode for batch and FIA systems, respectively. The electrodes exhibit good selectivity for RaCl with respect to a large number of common ions, sugars, amino acids, and components other than ranitidine hydrochloride of the investigated mixed drugs. The electrodes have been applied to the potentiometric determination of RaCl in pure solutions and in pharmaceutical preparations under batch and flow injection conditions with a lower detection limit of 1.26 × 10 -5 M and 5.62 × 10 -6 M at 25 ± 1˚C. An average recovery of 100.91% and 100.42% with a relative standard deviation of 0.72% and 0.53% has been achieved.

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“…The response time for the CTA-electrodes lies within the typical range for macroscopic ISE [23], i.e., the electrodes exhibit fast dynamic instantaneous response time in the order of 10±15 s for high analyte concentrations ( 5 1.9610 À5 M). Response time increases with the decrease of concentration of analyte reaching 30±60 s for middle concentrations ( 5 6.0610 À6 M) and 1±2 min for more lower analyte concentrations.…”

Section: Response Time Of the Electrodesmentioning

confidence: 75%

Cetyltrimethylammonium-Selective PVC Electrode Based On Its Trinitrobenzene Sulfonate Ion-Pair

et al. 1999

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A PVC membrane electrode selective for cetyltrimethylammonium ion was prepared. The active element is a plasticized polyvinyl chloride membrane containing a dissolved ion pair complex of CTAB with trinitrobenzene sulfonic acid (TNBS). The electrode showed a nearNernstian response within the CTA concentration range from 1.08610 76 to 8610 74 M at 25AE 1 C, good selectivity, precision (RSD 1.04 %), and usable within the pH range 2.5±10.2. The isothermal temperature coef®cient of the electrode amounted to 70.00007 Va C. The electrode has been used for the direct determination of cetyltrimethylammonium bromide either by the standard addition method or by potentiometric titration against TNBS at pH 7.

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Ion-selective membrane electrodes for the determination of the muscle relaxants pancuronium, tubocurarine, gallamine and succinylcholine

Cited by 25 publications

References 16 publications

Analytical applications of electrode sensitive to labetalol in pharmaceuticals

Analytical applications of electrode sensitive to labetalol in pharmaceuticals

Ion-Selective Electrodes for Potentiometric Determination of Ranitidine Hydrochloride, Applying Batch and Flow Injection Analysis Techniques

Cetyltrimethylammonium-Selective PVC Electrode Based On Its Trinitrobenzene Sulfonate Ion-Pair

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