Ion sensitive floating in situ gel for controlled delivery of famotidine and domperidone maleate for the treatment of gastro oesophageal reflux disease

Jorapur, Devika; Nagesh, C; Suma, N; Chandrasekhara, S; Attimarad, Sunil L; Kengeri, Savitha

doi:10.5958/0974-360x.2018.00369.4

Cited by 4 publications

(3 citation statements)

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“…Stability studies for F6 and F8 were performed for three months, at room temperature (30 ± 20ºC) and at 40ºC. Stability studies were carried out as per ICH guidelines [13,14].…”

Section: Stability Studiesmentioning

confidence: 99%

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Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Kumar

2023

Int J Pharm Sci

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Floating Drug Delivery Systems have been used to overcome some of the problems like low oral absorption of drugs with narrow absorption window as it has an advantage of sustained release of drugs over a prolonged period of time. In-situ gels are the novel approach in the context of floating drug delivery systems. The aim of this present study was to develop an oral stomach specific floating in-situ gel of Azithromycin dihydrate. In-situ gelling system was prepared by dissolving different concentrations of polymers like sodium alginate, xanthan gum in the de-ionized water already prepared with sodium citrate at 60°C to 90°C. After the heating with continuous stirring the formulation was cooled below the temperature of 40°C with the addition of certain amount of drug and calcium carbonate which acts as gas generating agent. All the formulations showed pH in the range of 6.1 to 6.7, drug content was found to be in the range of 97.29% to 99.27%. Floating lag time was less than 1 minute for all the formulations and the duration of floatation was more than 24 hours for the combination of polymers. Appearance and measurement of water uptake by the gel was also good. Stability studies were also done and was found to be at normal phase at different temperatures and at interval of times. Although, F9 showed the maximum properties of an in-situ gel with increased gastric retention time with low slowly release of the drug. Drug release was found to be decreasing as the concentration of polymer increases. However, it was concluded that the in-situ gelling system of Azithromycin dihydrate could be prepared in various concentrations of different polymers and the combination of polymers to increase the patient compliance and reduction in the frequency of dosing of the drug with the increased gastric residence time for the drug in the stomach.

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“…Stability studies for F6 and F8 were performed for three months, at room temperature (30 ± 20ºC) and at 40ºC. Stability studies were carried out as per ICH guidelines [13,14].…”

Section: Stability Studiesmentioning

confidence: 99%

“…Stability studies were carried out for the drug content, viscosity and pH of the formulations. The result of the particular evaluation is tabulated in the below Table 6 [13,14].…”

Section: Stability Studiesmentioning

confidence: 99%

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Kumar

2023

Int J Pharm Sci

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“…The gelling capacity of the formulation was assessed based on the gelling time and duration. 22,23 To assess the gelling time and duration, the following scores were given: +: Gels after a few seconds and is rapidly dispersed ++: Gels immediately and the formed gel remains buoyant for 12 h +++: Gels immediately and the formed gel remains buoyant for more than 12 h…”

Section: Determination Of Physical Appearance and Phmentioning

confidence: 99%

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Shabaraya,

T Ashwini,

Vineetha

2023

European Pharmaceutical Journal

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A revolutionary concept for achieving long-term medication release is the gastroretentive in situ gelling system. The goal of this research was to formulate and test a gastroretentive in situ gel for ketoprofen delivery to targeted site to increase the residence and delivery time. Ketoprofen gastroretentive in situ gels were synthesized using a cation-driven gelation approach using various combinations and concentrations of polymers such as gellan gum, sodium alginate, and hydroxypropyl methylcellulose (HPMC) K100M. Visual appearance, pH, viscosity, in vitro gelation, in vitro buoyancy, drug content, density measurement, gel strength measurement, water uptake, and in vitro drug release were all evaluated. The total floating time was more than 12 h, with a floating lag time of less than 2 min. The formulations showed pH ranging from 6.89 to 7.61 and drug content ranging from 82.01% to 95.53%. For 11 h, the percent cumulative drug release of formulations F5 and F14, which contained a greater concentration of polymer sodium alginate (1.5%) and a combination of gellan gum and HPMC K100M (0.175% and 0.2%), was 84.10% and 85.49%, respectively. In vitro dissolution experiments and stability investigations both revealed no significant changes in drug content. The findings revealed that the formulated in situ gels aided in extending gastric residence duration, allowing the drug to be released in the stomach.

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Formulation and Development of Sustained Release of Cefixime using Floating Oral In Situ Gelling System

Chaturvedi

Manigauha

2022

RJPT

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The present study was planned to prepare Gastro-retentive controlled release of floating in situ gel of Cefixime by using sodium alginate and xanthan gum. The six floating in situ gelling formulations (F1 to F6) were evaluated for visual appearance, pH, gelation, viscosity, buoyancy, drug content, water uptake, gel density, gel strength, drug release and stability. The results of above parameters were found to be satisfactorily. The F6 showed drug release for longer time and it was considered a best formation. The F6 were stable at the selected temperature and humidity when stored for 3 months. The findings it was concluded that the prepared sustained release in situ gel of Cefixime might be safe and effective controlled drug delivery for extended period of time.

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Ion sensitive floating in situ gel for controlled delivery of famotidine and domperidone maleate for the treatment of gastro oesophageal reflux disease

Cited by 4 publications

References 0 publications

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Formulation and Evaluation of Azithromycin Dihydrate Based In situ Gel as Floating Drug Delivery System

Formulation and Evaluation of Gastroretentive In Situ Gelling System of Ketoprofen

Formulation and Development of Sustained Release of Cefixime using Floating Oral In Situ Gelling System

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