Ionic gelation controlled drug delivery systems for gastric-mucoadhesive microcapsules of captopril

Altaf, MA; Sreedharan,; Charyulu, Narayana

doi:10.4103/0250-474x.45410

Cited by 13 publications

(7 citation statements)

References 10 publications

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“…This can be explained as due to the reinforcement by CA, which is in line with our previous work (Mooranian et al 2014a). The spectra observed in Figure 2b, d, f and h of chemical analysis showed dominant atoms (Na, O, Ca, S, and Cl) that are expected for a typical PB-SA and PB-CA-SA microcapsule prepared via ionic gelation methodology (Altaf 2008, Davignon, 1994. Na and Cl represent sodium chloride, a by-product of ionic gelation.…”

Section: Swelling Studiesmentioning

confidence: 98%

Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line

Mooranian

Negrulj

Arfuso

et al. 2015

Artificial Cells, Nanomedicine, and Biotechnology

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Section: Swelling Studiesmentioning

confidence: 98%

Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line

Mooranian

Negrulj

Arfuso

et al. 2015

Artificial Cells, Nanomedicine, and Biotechnology

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“… 69 Nevertheless, nanoparticles produced through this combined approach exhibit excellent physical stability, owing to the role of the added stabilizers during the emulsification process. 80 , 81 Despite its drawbacks, the utilization of both techniques offers a promising strategy for achieving enhanced stability and controlled release properties in drug-loaded nanoparticles.…”

Section: Preparation Methods In Developing Chitosan/alginate-based Na...mentioning

confidence: 99%

Chitosan/Alginate-Based Nanoparticles for Antibacterial Agents Delivery

Wathoni,

Herdiana,

Suhandi

et al. 2024

IJN

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Nanoparticle systems integrating alginate and chitosan emerge as a promising avenue to tackle challenges in leveraging the potency of pharmacological active agents. Owing to their intrinsic properties as polysaccharides, alginate and chitosan, exhibit remarkable biocompatibility, rendering them conducive to bodily integration. By downsizing drug particles to the nano-scale, the system enhances drug solubility in aqueous environments by augmenting surface area. Additionally, the system orchestrates extended drug release kinetics, aligning well with the exigencies of chronic drug release requisite for antibacterial therapeutics. A thorough scrutiny of existing literature underscores a wealth of evidence supporting the utilization of the alginate-chitosan nanoparticle system for antibacterial agent delivery. Literature reviews present abundant evidence of the utilization of nanoparticle systems based on a combination of alginate and chitosan for antibacterial agent delivery. Various experiments demonstrate enhanced antibacterial efficacy, including an increase in the inhibitory zone diameter, improvement in the minimum inhibitory concentration, and an enhancement in the bacterial reduction rate. This enhancement in efficacy occurs due to mechanisms involving increased solubility resulting from particle size reduction, prolonged release effects, and enhanced selectivity towards bacterial cell walls, stemming from ionic interactions between positively charged particles and teichoic acid on bacterial cell walls. However, clinical studies remain limited, and there are currently no marketed antibacterial drugs utilizing this system. Hence, expediting clinical efficacy validation is crucial to maximize its benefits promptly.

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“…After the initial dose is delivered by the immediate release layer, the sustained release layer absorbs the gastric fluid and forms a colloidal gel barrier on its surface. This produces a bulk density less than that of the gastric fluid and remains buoyant in the stomach for extended period of time (Altaf et al,2008)Bilayer tablet is shown in Figure 6.…”

Section: Bilayer Tabletmentioning

confidence: 99%

Gastroretentive drug delivery systems: A review

Satinderkakar¹,

Shallusandhan²

2015

Afr. J. Pharm. Pharmacol.

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Oral administration has only limited use for important drugs from various pharmacological categories, that have poor oral bio-availability due to incomplete absorption and/or degradation in the gastrointestinal tract (GIT). Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short half-life are eliminated quickly from the blood circulation, so they require frequent dosing. To avoid this drawback, the oral sustained-controlled release formulations have been developed in an attempt to release the drug slowly into the gastrointestinal tract (GIT) and maintain an effective drug concentration in the serum for longer period of time. However, such oral drug delivery devices have a physiological limitation of gastric retention time (GRT), variable and short gastric emptying time can result in incomplete drug release from the drug delivery system (DDS) in the absorption zone (stomach or upper part of small intestine), leading to diminished efficacy of the administered dose. The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to achieve promptly and then maintain the desired drug concentration. This idealized objective points to the two aspects most important to the drug delivery; namely spatial placement and temporal delivery of a drug. Spatialplacement relates to targeting a drug to a specific organ or a tissue while temporal delivery refers to controlling the rate of drug delivery to that specific organ or a Tissue.

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Ionic gelation controlled drug delivery systems for gastric-mucoadhesive microcapsules of captopril

Cited by 13 publications

References 10 publications

Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line

Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line

Chitosan/Alginate-Based Nanoparticles for Antibacterial Agents Delivery

Gastroretentive drug delivery systems: A review

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