Ionic liquid-based compound droplet microfluidics for ‘on-drop’ separations and sensing

Barikbin, Zahra; Rahman, Md. Taifur; Parthiban, Pravien; Rane, Anandkumar; Jain, Vaibhav; Duraiswamy, Suhanya; Lee, S. H. Sophia; Khan, Saif A.

doi:10.1039/c004853d

Cited by 45 publications

(27 citation statements)

References 59 publications

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“…As a proof-of-concept, we demonstrated the synthesis of PtNPs by a polyol reduction in droplet flows of 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BMIM-Tf 2 N) ionic liquid solvent. There are few examples of droplet flows of ionic liquids because they represent an exceptional case of droplet flow behaviour as a result of their complex interfacial properties and high viscosity 1 24 25 . Here, BMIM-Tf 2 N ionic liquid droplets are formed trivially in a modified droplet generator with three inlets to accommodate two reagent/dispersed phase streams ( Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Flow invariant droplet formation for stable parallel microreactors

et al. 2016

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The translation of batch chemistries onto continuous flow platforms requires addressing the issues of consistent fluidic behaviour, channel fouling and high-throughput processing. Droplet microfluidic technologies reduce channel fouling and provide an improved level of control over heat and mass transfer to control reaction kinetics. However, in conventional geometries, the droplet size is sensitive to changes in flow rates. Here we report a three-dimensional droplet generating device that exhibits flow invariant behaviour and is robust to fluctuations in flow rate. In addition, the droplet generator is capable of producing droplet volumes spanning four orders of magnitude. We apply this device in a parallel network to synthesize platinum nanoparticles using an ionic liquid solvent, demonstrate reproducible synthesis after recycling the ionic liquid, and double the reaction yield compared with an analogous batch synthesis.

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Section: Resultsmentioning

confidence: 99%

Flow invariant droplet formation for stable parallel microreactors

et al. 2016

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“…Numerous methods of droplet generation are shown in Figure 6b, together with different modes of the performance of a measuring system. The ionic liquid-based droplet microfluidic set-up for "on-drop" separations and colorimetric pH sensing, involving the creation of two-phase droplet structures in a continuous phase of silicon oil, is yet another example of a wise use of the above-discussed concept [276].…”

Section: Microfluidics In Flow Analysis and Flow Synthesismentioning

confidence: 99%

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

Trojanowicz

2020

Molecules

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Flow chemistry is an area of contemporary chemistry exploiting the hydrodynamic conditions of flowing liquids to provide particular environments for chemical reactions. These particular conditions of enhanced and strictly regulated transport of reagents, improved interface contacts, intensification of heat transfer, and safe operation with hazardous chemicals can be utilized in chemical synthesis, both for mechanization and automation of analytical procedures, and for the investigation of the kinetics of ultrafast reactions. Such methods are developed for more than half a century. In the field of chemical synthesis, they are used mostly in pharmaceutical chemistry for efficient syntheses of small amounts of active substances. In analytical chemistry, flow measuring systems are designed for environmental applications and industrial monitoring, as well as medical and pharmaceutical analysis, providing essential enhancement of the yield of analyses and precision of analytical determinations. The main concept of this review is to show the overlapping of development trends in the design of instrumentation and various ways of the utilization of specificity of chemical operations under flow conditions, especially for synthetic and analytical purposes, with a simultaneous presentation of the still rather limited correspondence between these two main areas of flow chemistry.

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“…Ionic liquids are low temperature melting salts with very low vapor pressure. Thanks to their low vapor pressure, ILs are ideal extraction solvents or reaction media because simple evaporation methods can be used to separate solutes from ILs [3]. In addition, ILs can be custom-made with targeted functions.…”

Section: Introductionmentioning

confidence: 99%

Octadecyltrichlorosilane (OTS)-coated ionic liquid drops: Micro-reactors for homogenous catalytic reactions at designated interfaces

Zhang¹,

Cai²

2012

Beilstein J. Nanotechnol.

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SummaryAn ionic liquid (IL), 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) can assemble on prefabricated carboxylic acid–terminated chemical patterns on octadecyltrichlorosilane (OTS) film. The chemical pattern controls the position, shape and size of the IL on the surface. After the IL assembly – by incubating IL drops assembled on sample surface in an OTS silane vapor – an OTS layer was coated on the IL drop surface which encapsulated the IL drop. The OTS-coated capsule can exist stably under aqueous solution. The OTS coating protected the IL drops from being instantaneously dissolved by other solutions. We found that a homogenous catalyst (FeCl3) dissolved in [Bmim]Cl can be assembled together on the chemical patterns and subsequently encapsulated together with [Bmim]Cl by OTS coating. The pinhole defects within the vapor-coated silane layer provide space for the catalyst inside the capsule and reactants outside the capsule to meet and react. When the OTS-coated capsule containing a FeCl3/IL mixture was soaked under H2O2 solution, the Fe3+ ions catalyzed the decomposition reaction of hydrogen peroxide at the vapor-coated OTS-water interface. Since the shape and position of the interface is defined by the underneath chemical pattern, our findings show that the OTS-coated IL drops assembled on chemical patterns can be used as novel micro-reactors. This allows homogenous catalytic reactions to occur at the designated interfaces.

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Ionic liquid-based compound droplet microfluidics for ‘on-drop’ separations and sensing

Cited by 45 publications

References 59 publications

Flow invariant droplet formation for stable parallel microreactors

Flow invariant droplet formation for stable parallel microreactors

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

Octadecyltrichlorosilane (OTS)-coated ionic liquid drops: Micro-reactors for homogenous catalytic reactions at designated interfaces

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