Ionic liquid under ultrasonic irradiation towards a facile synthesis of pyrazolone derivatives

Abstract

Ionic liquid [HMIM]HSO(4) was found to be an efficient catalyst for the synthesis of 4-[(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-phenyl-methyl]-5-methyl-2-phen-yl-1,2-dihydro-pyrazol-3-ones through the condensation reaction of arylaldehydes and 3-methyl-1-phenyl-5-pyrazolone under ultrasonic irradiation at room temperature. The present methodology offers several advantages such as excellent yields, simple procedure and mild conditions.

Ionic Liquids: Future Solvents and Reagents for Pharmaceuticals

“…In recent years, ILs have been found to be excellent solvents for dissolution of nucleosides (Uzagare et al, 2003;Kumar et al, 2007; Moniruzzaman et al, 2010c). This finding opens the door to using ILs as reaction media for synthesis of nucleoside analogs with many advantages over conventional solvents (Uzagare et al, 2003;Malhotra, 2008, 2009;Zhang et al, 2009;Zang et al, 2011). Uzagare et al (2003) have reported on the acylation of 3Ј-and 5Ј-functional groups of sugars and NH 2 of base of 2Ј-deoxynucleosides in IL [MOemim][OMs] with different acylating agents including acetic anhydride, benzoyl chloride and isobutyryl chloride (see Figure 3).…”

Nano Copper Ferrite Catalyzed Sonochemical, One-Pot Three and Four Component Synthesis of Poly Substituted Imidazoles

“…These directly help in shortening the time span of reactions and increasing the yield of products [56]. Moreover a large number of reactions can be carried out in shorter reaction time, higher yield through milder reaction conditions under Ultra sound Irradiation [57]- [59]. Many homogeneous and heterogeneous reactions can be conducted smoothly by sonication to provide improved yields and increased selectivity [60].…”

Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives

“…Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. These include anti-inflammatory, antipyretic and analgesic activities, uses as bactericides and fungicides, and promising inhibitory activity against monoamine oxidase for the treatment of Parkinson's and Alzheimer's diseases [1,4,[12][13][14]. More specifically, 4,4 1 -(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ol)s is an important class of pyrazolones used as anti-inflammatories [15], antipyretics, gastric secretion stimulatories [16], antidepressants [17], and antibacterial and anti-filaria agents [11,[18][19][20].…”