2014
DOI: 10.1039/c3cc48650h
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Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility

Abstract: Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.

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Cited by 128 publications
(106 citation statements)
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“…For example, some biocompatible ILs have already been synthesized including cholinium-based ILs, amino acid-based ILs or pharmaceutically acceptable ILs (11)(12)(13)(14)(15)(16). However, the design of entirely green ILs is still very limited.…”
Section: Introductionmentioning
confidence: 99%
“…For example, some biocompatible ILs have already been synthesized including cholinium-based ILs, amino acid-based ILs or pharmaceutically acceptable ILs (11)(12)(13)(14)(15)(16). However, the design of entirely green ILs is still very limited.…”
Section: Introductionmentioning
confidence: 99%
“…[22,24] Since 2007, Room Temperature Ionic Liquids (RTILs) containing active pharmaceutical ingredients have aroused strong interests as they limit drugs polymorphism and improve their solubility. [29][30][31][32][33] API-ILs have also been used as solvent for poorly soluble drugs [34][35][36][37][38] and as drug delivery systems in the form of microemulsions [39] and micelles. [40] Drug delivery systems have also been obtained by immobilization of API-ILs into silica either by sol-gel processing, [41] adsorption to silica [42] or into biocompatible poly(L-lactic acid).…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4] The emergent physicochemical properties of these materials are associated with the combination of bulk and surface properties of aggregates. 2 Moreover, functionalization of nanoparticles using chemical groups that have more affinity with biological molecules, such as viruses, DNA, and RNA, can have a significant impact on the development of virus detections, environmental monitoring, and bio-probe techniques.…”
Section: Introductionmentioning
confidence: 99%