Ionic regulation of embryonic induction and cell differentiation in Rana Pipiens

Barth, L. G.

doi:10.1016/s0012-1606(74)80004-7

Cited by 75 publications

(14 citation statements)

References 22 publications

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“…They noted that this phenomenon can be induced by ionic changes in the medium and then enhanced or inhibited by specific electromagnetic signals. This ionic sensitivity of the cell called <( reactivation ) > was observed by several authors (Cone, 1976 ;Barth, 1969Barth, , 1972Barth, , 1974.…”

Section: Infroductionmentioning

confidence: 56%

Morphological effect of electromagnetic stimulation on the skeleton of fetal or newborn mice

Hinsenkamp¹,

Rooze²

1982

Acta Orthopaedica Scandinavica

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Section: Infroductionmentioning

confidence: 56%

Morphological effect of electromagnetic stimulation on the skeleton of fetal or newborn mice

Hinsenkamp¹,

Rooze²

1982

Acta Orthopaedica Scandinavica

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“…In normal development, embryonic stem cells gradually progress from a multipotent state, capable of generating all cell types, to a highly restricted state by sequential restriction of differentiation potential (Chambers and Studer, 2011). These differentiation processes have been shown to be subject to manipulation from various signaling cues, such as transcription factor expression (Mong et al, 2014, Weintraub et al, 1989 but have also been shown to be directed by bioelectrical events (Barth and Barth, 1974, Lange et al, 2011, Sundelacruz et al, 2009. While much of this work has been done in vitro, our data suggest that in vivo depolarization can also affect cell fate determination.…”

Section: D'mentioning

confidence: 99%

Selective depolarization of transmembrane potential alters muscle patterning and muscle cell localization in Xenopus laevis embryos

Lobikin

Paré²,

Kaplan³

et al. 2015

Int. J. Dev. Biol.

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The correct anatomical placement and precise determination of specific cell types is required for the establishment of normal embryonic patterning. Understanding these processes is also important for progress in regenerative medicine and cancer biology. Transmembrane voltage gradients across embryonic tissues can mediate cellular communication to regulate the processes of proliferation, migration, and differentiation. Our past work showed that selective depolarization of an endogenous instructor cell population in Xenopus laevis in vivo induced a melanoma-like phenotype in the absence of genetic damage. Here, we use a hypersensitive glycine-gated chloride channel (GlyR) under control of tissue-specific promoters to show that instructor cells resident within muscle are more effective at triggering the metastatic conversion of ectodermal melanocytes than those similar cells within the nervous system. Moreover, depolarization of muscle cells results in aberrant muscle patterning and the appearance of cells expressing muscle markers within the neural tube, which impacts but does not abolish the animals' ability to learn in an associative conditioning assay. Taken together, our data reveal new details of long-range (non-cell-autonomous) reprogramming of cell behavior via alteration of the resting potential of specific embryonic subpopulations.

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“…Early links between ion flow and differentiation were observed by Barth and co-workers, who showed that ventral ectoderm explants could be differentiated into a variety of different cell types by careful modulation of extracellular medium ion content [114, 115]. Bioelectric signals apply not only to embryonic cell differentiation, but also to stem cells, which have unique profiles with respect to ion channel expression and physiological state [116–123].…”

Section: Cellular-level Processes: What Can Bioelectric Signals Do?mentioning

confidence: 99%

Bioelectric mechanisms in regeneration: Unique aspects and future perspectives

Levin

2009

Seminars in Cell & Developmental Biology

181

165

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Regenerative biology has focused largely on chemical factors and transcriptional networks. However, endogenous ion flows serve as key epigenetic regulators of cell behavior. Bioelectric signaling involves feedback loops, long-range communication, polarity, and information transfer over multiple size scales. Understanding the roles of endogenous voltage gradients, ion flows, and electric fields will contribute to the basic understanding of numerous morphogenetic processes and the means by which they can robustly restore pattern after perturbation. By learning to modulate the bioelectrical signals that control cell proliferation, migration, and differentiation, we gain a powerful set of new techniques with which to manipulate growth and patterning in biomedical contexts. This chapter reviews the unique properties of bioelectric signaling, surveys molecular strategies and reagents for its investigation, and discusses the opportunities made available for regenerative medicine.

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Ionic regulation of embryonic induction and cell differentiation in Rana Pipiens

Cited by 75 publications

References 22 publications

Morphological effect of electromagnetic stimulation on the skeleton of fetal or newborn mice

Morphological effect of electromagnetic stimulation on the skeleton of fetal or newborn mice

Selective depolarization of transmembrane potential alters muscle patterning and muscle cell localization in Xenopus laevis embryos

Bioelectric mechanisms in regeneration: Unique aspects and future perspectives

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