Ionic Strength and Thermal Dual‐Responsive Bilayer Hollow Spherical Hydrogel Actuator

Zhou, Shengzhu; Wu, Baoyi; Zhou, Qiang; Jian, Yukun; Le, Xiaoxia; Lu, Huanhuan; Zhang, Dachuan; Zhang, Jiawei; Zhang, Zhihui; Chen, Tao

doi:10.1002/marc.201900543

Cited by 35 publications

(15 citation statements)

References 32 publications

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“…Intelligent soft materials have attracted increasing attention during the past decades whose macroscopic structure and physical properties show a significant change in response to specific stimuli. [ 35–39 ] With the reversible linkages in hydrogels demonstrated above, the prepared hydrogels are promising as stimuli‐responsive macroscopic structures. As illustrated in Figure a, the hydrogel network could be completely destroyed by increasing the temperature or applying ultrasound.…”

Section: Resultsmentioning

confidence: 99%

Transparent Conductive Supramolecular Hydrogels with Stimuli‐Responsive Properties for On‐Demand Dissolvable Diabetic Foot Wound Dressings

Zhao

et al. 2020

Macromol. Rapid Commun.

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Diabetic foot ulcer (DFU) is a common complication in patients with diabetic hyperglycemia, which leaves patients at increased high risk of morbidity, infection, nontraumatic limb amputations, and even early death. [1-5] Among various efforts to address this urgent issue, wound dressings are effective strategies to provide an optimal environment for wound repair. [6,7] Traditional wound dressings for DFU treatment typically cover rubber, electrospun nanofiber, cotton wool, natural or synthetic bandages, and gauzes. [8,9] Although these dry dressings are convenient to control the initial state of wound healing, they tend to adhere to the wound area once the absorbed blood and exudate dry out. [7] Besides, the dry dressings still suffer from limitations of maintaining a moisture environment, allowing gaseous exchange, and preventing infection. [6,7] In this context, a wound dressing that can deal with the above shortcomings would be ideal to speed up diabetic foot wounds healing and improve treatment outcomes. In recent years, hydrogels have generated tremendous interest in wound healing applications. [10-16] As water-based soft materials, hydrogels can facilitate wound healing by absorbing wound exudate, preventing wound desiccation, and isolating the wound from the environment, which makes them the best choice for wound healing. [17,18] However, the currently available hydrogel dressings still require to be changed frequently, which is a laborious process and inevitably cause reinjury of the wounds, wound infection, delayed healing time, and personal suffering. [19] To this end, on-demand dissolvable hydrogels represent a new class of emerging "smart" wound dressings that can be readily operated and painlessly removed. [19-24] Generally, this type of hydrogels can form in situ and dissolve on-demand via physical crosslinking cases and chemical crosslinking cases. The dissolution of physically crosslinked hydrogels is based on physical interactions, such as molecular entanglements and/or secondary forces (e.g., ionic, H-bonding, and hydrophobic associations). [19,20,22,23] Diabetic foot ulcers (DFU) remain a very considerable health care burden, and their treatment is difficult. Hydrogel-based wound dressings are appealing to provide an optimal environment for wound repair. However, the currently available hydrogel dressings still need surgical or mechanical debridement from the wound, causing reinjury of the newly formed tissues, wound infection, delayed healing time, and personal suffering. Additionally, to meet people's increasing demand, hydrogel wound dressings with improved performance and multifunctionality are urgently required. Here, a new multifunctional supramolecular hydrogel for on-demand dissolvable diabetic foot wound dressings is designed and constructed. Based on multihydrogen bonds between hydrophilic polymers, the resultant supramolecular hydrogels present controlled and excellent properties, such as good transparency, antibacterial ability, conductive, and self-healing properties. Thus, the sup...

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Section: Resultsmentioning

confidence: 99%

Transparent Conductive Supramolecular Hydrogels with Stimuli‐Responsive Properties for On‐Demand Dissolvable Diabetic Foot Wound Dressings

Zhao

et al. 2020

Macromol. Rapid Commun.

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“…Fortunately, some flexible optical waveguide materials, such as hydrogels and PDMS, are good light guide materials and typical stimuli-responsive polymers. Hydrogels have dramatic responsiveness to humidity (Figure A), − temperature (Figure B), ,− ionic strength (Figure C), , light, and so on, PDMS also has obvious responsiveness to external stimuli such as volatility and nonvolatile compounds − and temperature. , …”

Section: Soft and Stretchable Optical Waveguide And Novel Applicationsmentioning

confidence: 99%

“…(C) Ionic strength-responsive hydrogels deform under ionic strength stimulation. Reproduced with permission from ref . Copyright (2020) John Wiley and Sons.…”

Section: Soft and Stretchable Optical Waveguide And Novel Applicationsmentioning

confidence: 99%

Soft and Stretchable Optical Waveguide: Light Delivery and Manipulation at Complex Biointerfaces Creating Unique Windows for On-Body Sensing

Liu

2021

ACS Sens.

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Over the past few decades, optical waveguides have been increasingly used in wearable/implantable devices for onbody sensing. However, conventional optical waveguides are stiff, rigid, and brittle. A mismatch between conventional optical waveguides and complex biointerfaces makes wearable/implantable devices uncomfortable to wear and potentially unsafe. Soft and stretchable polymer optical waveguides not only inherit many advantages of conventional optical waveguides (e.g., immunity to electromagnetic interference and without electrical hazards) but also provide a new perspective for solving the mismatch between conventional optical waveguides and complex biointerfaces, which is essential for the development of light-based wearable/ implantable sensors. In this review, polymer optical waveguides' unique properties, including flexibility, biocompatibility and biodegradability, porosity, and stimulus responsiveness, and their applications in the wearable/implantable field in recent years are summarized. Then, we briefly discuss the current challenges of high optical loss, unstable signal transmission, low manufacturing efficiency, and difficulty in deployment during implantation of flexible polymer optical waveguides, and propose some possible solutions to these problems.

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“…In the present contribution, we focus on stimuli-responsive chemical hydrogels. Typical stimuli include variations in temperature [11], pH [11], applied stress [12], magnetic and electromagnetic field [13], ionic strength [14], light [15] and the presence of bioactive species [16]. Redox-responsive gels have been scarcely reported.…”

Section: Introductionmentioning

confidence: 99%

Application of Redox-Responsive Hydrogels Based on 2,2,6,6-Tetramethyl-1-Piperidinyloxy Methacrylate and Oligo(Ethyleneglycol) Methacrylate in Controlled Release and Catalysis

Khodeir

Vlad

2021

Polymers

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Hydrogels have reached momentum due to their potential application in a variety of fields including their ability to deliver active molecules upon application of a specific chemical or physical stimulus and to act as easily recyclable catalysts in a green chemistry approach. In this paper, we demonstrate that the same redox-responsive hydrogels based on polymer networks containing 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) stable nitroxide radicals and oligoethylene glycol methyl ether methacrylate (OEGMA) can be successfully used either for the electrochemically triggered release of aspirin or as catalysts for the oxidation of primary alcohols into aldehydes. For the first application, we take the opportunity of the positive charges present on the oxoammonium groups of oxidized TEMPO to encapsulate negatively charged aspirin molecules. The further electrochemical reduction of oxoammonium groups into nitroxide radicals triggers the release of aspirin molecules. For the second application, our hydrogels are swelled with benzylic alcohol and tert-butyl nitrite as co-catalyst and the temperature is raised to 50 °C to start the oxidation reaction. Interestingly enough, benzaldehyde is not miscible with our hydrogels and phase-separate on top of them allowing the easy recovery of the reaction product and the recyclability of the hydrogel catalyst.

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Ionic Strength and Thermal Dual‐Responsive Bilayer Hollow Spherical Hydrogel Actuator

Cited by 35 publications

References 32 publications

Transparent Conductive Supramolecular Hydrogels with Stimuli‐Responsive Properties for On‐Demand Dissolvable Diabetic Foot Wound Dressings

Transparent Conductive Supramolecular Hydrogels with Stimuli‐Responsive Properties for On‐Demand Dissolvable Diabetic Foot Wound Dressings

Soft and Stretchable Optical Waveguide: Light Delivery and Manipulation at Complex Biointerfaces Creating Unique Windows for On-Body Sensing

Application of Redox-Responsive Hydrogels Based on 2,2,6,6-Tetramethyl-1-Piperidinyloxy Methacrylate and Oligo(Ethyleneglycol) Methacrylate in Controlled Release and Catalysis

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