Ionic-surfactant-mediated electro-dewetting for digital microfluidics

Jia, Li; Ha, Noel S.; Liu, Tingyi; Dam, R. Michael van; Kim, Chang‐Jin

doi:10.1038/s41586-019-1491-x

Cited by 214 publications

(222 citation statements)

References 47 publications

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“…This study demonstrates a bioinspired bioanalysis platform for rapid, point-of-care diagnostics of urinary stone disease. The ultra-repellency of SLIPS, as indicated by a small contact angle hysteresis, significantly reduces the friction and enables autonomous droplet transportation (32,33), SLIPS-LAB allows liquid handling procedures without the requirement of external power or control. Furthermore, microfluidics, because of the large surface-tovolume ratio, is highly prone to biofouling and clogging of channels (34).…”

Section: Discussionmentioning

confidence: 99%

SLIPS-LAB—A bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

Shkolyar

Wang

et al. 2020

Sci. Adv.

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Urinary stone disease is among the most common medical conditions. Standard evaluation of urinary stone disease involves a metabolic workup of stone formers based on measurement of minerals and solutes excreted in 24-hour urine samples. Nevertheless, 24-hour urine testing is slow, expensive, and inconvenient for patients, which has hindered widespread adoption in clinical practice. Here, we demonstrate SLIPS-LAB (Slippery Liquid-Infused Porous Surface Laboratory), a droplet-based bioanalysis system, for rapid measurement of urinary stone–associated analytes. The ultra-repellent and antifouling properties of SLIPS, which is a biologically inspired surface technology, allow autonomous liquid handling and manipulation of physiological samples without complicated sample preparation procedures and supporting equipment. We pilot a study that examines key urinary analytes in clinical samples from patients with urinary stone. The simplicity and speed of SLIPS-LAB hold the potential to provide actionable diagnostic information for patients with urinary stone disease and rapid feedback for responses to dietary and pharmacologic treatments.

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Section: Discussionmentioning

confidence: 99%

SLIPS-LAB—A bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

Shkolyar

Wang

et al. 2020

Sci. Adv.

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“…The droplets can be picked up, transported, and lay down on a hydrophobic substrate . Furthermore, other electric field‐based devices for droplets manipulation, such as electrohydrodynamic technique for mixing droplets, manipulation of organic droplets underwater, ionic‐surfactant‐mediated electro‐dewetting for manipulating droplets in digital microfluidics, greatly promoted the develop of electric field‐based droplets manipulation.…”

Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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121

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Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust “alive” artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic‐based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T‐junction, flow‐focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet‐based and vesicle‐based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic‐based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

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“…However, its commercial success has been limited, because the required hydro phobic dielectric (electrically insulating) surfaces gradually degrade. On page 507, Li et al 8 report an approach to tune the wettability of chemically robust hydrophilic surfaces by electrically controlling the adsorption and desorption of molecules called surfactants. If this technology is successful, it might help to turn some previous EWOD-based systems into reliable devices.…”

Section: F R I E D E R M U G E L Ementioning

confidence: 99%

“…An applied voltage generates an electric force that causes this angle to decrease. b, Li et al 8 report a technique dubbed electro-dewetting, in which a droplet is placed on a nanometre-thick hydrophilic layer. The solid-liquid interfacial tension is smaller than the solid-gas interfacial tension and the contact angle is small.…”

Section: F R I E D E R M U G E L Ementioning

confidence: 99%

Droplet motion electrically controlled

Mugele¹

2019

Nature

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Ionic-surfactant-mediated electro-dewetting for digital microfluidics

Cited by 214 publications

References 47 publications

SLIPS-LAB—A bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

SLIPS-LAB—A bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Droplet motion electrically controlled

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