This study made the digital system to perform screening (early prediction) of Hypoxemia using MAX30102 sensor with the fuzzy value from SpO2 level and heart rate. This research also uses the Internet of Things (IoT) system to gather data from devices to the cloud. Hypoxemia is a lack of oxygen in the blood flowing in the body. Hypoxemia conditions in the body due to lack of oxygen levels in the blood will cause an increased heart rate. Hypoxemia conditions that are not immediately recognized cause damage to cells, tissues, and organs. Hypoxemia is an essential condition because information about oxygen levels in the blood is closely related to health conditions. In this project, researchers built a Hypoxemia early detection system. From the research results, it is found that the accuracy rate of the system to detect hypoxemia is 80%, with 60% sensitivity and 100% specificity. Based on the experiment, this research is able to help screening detection (early prediction) of Hypoxemia.