2013
DOI: 10.2174/1875414701003010043
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Iota Toxin, S Toxin and CDT: Members of the Same Class of Clostridial Binary Toxins in Feces of Humans and Other Animals

Abstract: Some strains of Clostridium perfringens, Clostridium spiroforme and Clostridium difficile produce binary toxins known respectively as iota toxin, S toxin and CDT. Each toxin consists of two unlinked polypeptides (e.g. CDTa and CDTb) that only together have biological activity. Taking an historical perspective, we review the development and early use of assays employing the specific neutralization of a biological activity for the detection and quantification of binary toxin. The survey moves on to more recent i… Show more

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“…Various combinations of rCPILE-b and the trypsin-treated rCPILE-b (0.1 μg:0.9 μg, 1 μg:9 μg, and 10 μg:90 μg) were prepared in 1.0 ml of PBS and injected into a loop of the ileum. The doses of rCPILE were based on a previous study [ 25 ]. Cholera toxin (Wako Chemicals, Osaka, Japan) was injected as a positive control (1 μg/loop).…”
Section: Methodsmentioning
confidence: 99%
“…Various combinations of rCPILE-b and the trypsin-treated rCPILE-b (0.1 μg:0.9 μg, 1 μg:9 μg, and 10 μg:90 μg) were prepared in 1.0 ml of PBS and injected into a loop of the ileum. The doses of rCPILE were based on a previous study [ 25 ]. Cholera toxin (Wako Chemicals, Osaka, Japan) was injected as a positive control (1 μg/loop).…”
Section: Methodsmentioning
confidence: 99%