iPRECON: an integrated preconcentrator for the enrichment of volatile organics in exhaled breath

Kokoric, Vjekoslav; Wilk, A.; Mizaikoff, Boris

doi:10.1039/c5ay00399g

Cited by 21 publications

(23 citation statements)

References 22 publications

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“…Furthermore, it is shown that iHWG structures readily combine with microfluidic technologies providing an integrated liquid phase sampling accessory for vapor phase studies. Based on the present results, the versatility of iHWGs previously demonstrated for the detection of environmentally/industrially relevant gases [17][18][19][20] and (bio)medically interesting analytes 21,22 may now be expanded towards vapor phase studies of liquids. As indicated, the remaining parameters may be combined into an instrumental and environmental factor K, which is constant if p and T are constant.…”

Section: Measuring 12 X 255s Sample Vapormentioning

confidence: 77%

Determining the Partial Pressure of Volatile Components via Substrate-Integrated Hollow Waveguide Infrared Spectroscopy with Integrated Microfluidics

et al. 2018

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A microfluidic system combined with substrate-integrated hollow waveguide (iHWG) vapor phase infrared spectroscopy has been developed for evaluating the chemical activity of volatile compounds dissolved in complex fluids. Chemical activity is an important yet rarely exploited parameter in process analysis and control. Access to chemical activity parameters enables systematic studies on phase diagrams of complex fluids, the detection of aggregation processes, etc. The instrumental approach developed herein uniquely enables controlled evaporation/permeation from a sample solution into a hollow waveguide structure and the analysis of the partial pressures of volatile constituents. For the example of a binary system, it was shown that the chemical activity may be deduced from partial pressure measurements at thermodynamic equilibrium conditions. The combined microfluidic-iHWG midinfrared sensor system (μFLUID-IR) allows the realization of such studies in the absence of any perturbations provoked by sampling operations, which is unavoidable using state-of-the-art analytical techniques such as headspace gas chromatography. For demonstration purposes, a water/ethanol mixture was investigated, and the derived data was cross-validated with established literature values at different mixture ratios. Next to perturbation-free measurements, a response time of the sensor <150 s ( t) at a recovery time <300 s ( t) has been achieved, which substantiates the utility of μFLUID-IR for future process analysis-and-control applications.

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Section: Measuring 12 X 255s Sample Vapormentioning

confidence: 77%

Determining the Partial Pressure of Volatile Components via Substrate-Integrated Hollow Waveguide Infrared Spectroscopy with Integrated Microfluidics

et al. 2018

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“…1(D)) was developed by our research team based on the design of an earlier published iPRECON prototype. 16 However, in comparison to the previous device the muciPRECON (see Fig. 2) now provides three individual sorbent channels that are integrated into an aluminium substrate.…”

Section: (C) Results and Discussion Muciprecon Designmentioning

confidence: 99%

muciPRECON: multichannel preconcentrators for portable mid-infrared hydrocarbon gas sensors

et al. 2016

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“…Furthermore, iHWGs are robust and cost-efficient, and their shape, absorption path length, and surface coating may readily be tailored to specific application needs. Using iHWGs in combination with a variety of IR light sources ranging from FTIR spectrometers to quantum cascade and interband cascade lasers (QCLs, ICLs), detection limits (LOD) in the low percentage, 5 ppm 3,6,8 or the medium ppb 4,7 range were achieved.…”

Section: Introductionmentioning

confidence: 99%

Portable combination of Fourier transform infrared spectroscopy and differential mobility spectrometry for advanced vapor phase analysis

Hagemann

McCartney

Fung

et al. 2018

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Designing mobile devices for the analysis of complex sample mixtures containing a variety of analytes at different concentrations across a large dynamic range remains a challenging task in many analytical scenarios. To meet this challenge, a compact hybrid analytical platform has been developed combining Fourier transform infrared spectroscopy based on substrate-integrated hollow waveguides (iHWG-FTIR) with gas chromatography coupled differential mobility spectrometry (GC-DMS). Due to the complementarity of these techniques regarding analyte type and concentration, their combination provides a promising tool for the detection of complex samples containing a broad range of molecules at different concentrations. To date, the combination of infrared spectroscopy and ion mobility techniques remains expensive and bound to a laboratory utilizing e.g. IMS as prefilter or IR as ionization source. In the present study, a cost-efficient and portable solution has been developed and characterized representing the first truly hyphenated IR-DMS system. As a model analyte mixture, 5 ppm isopropylmercaptan (IPM) in methane (CH4) were diluted, and the concentration-dependent DMS signal of IPM along with the concentration-dependent IR signal of CH4 were recorded for all three hybrid IR-DMS systems. While guiding the sample through the iHWG-FTIR or the GC-DMS first did not affect the obtained signals, optimizing the IR data acquisition parameters did benefit the analytical results.

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iPRECON: an integrated preconcentrator for the enrichment of volatile organics in exhaled breath

Abstract: Automated substrate-integrated preconcentrator (iPRECON) for breath diagnostics.

Cited by 21 publications

References 22 publications

Determining the Partial Pressure of Volatile Components via Substrate-Integrated Hollow Waveguide Infrared Spectroscopy with Integrated Microfluidics

Determining the Partial Pressure of Volatile Components via Substrate-Integrated Hollow Waveguide Infrared Spectroscopy with Integrated Microfluidics

muciPRECON: multichannel preconcentrators for portable mid-infrared hydrocarbon gas sensors

Portable combination of Fourier transform infrared spectroscopy and differential mobility spectrometry for advanced vapor phase analysis

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