Ipsilateral Irradiation for Oral and Oropharyngeal Carcinoma Treated With Primary Surgery and Postoperative Radiotherapy

Vergeer, Marije R.; Doornaert, P.; Jonkman, A.; Kaanders, Johannes H.A.M.; Ende, Piet L.A. van den; Jong, M.A. de; Leemans, C. René; Slotman, Ben J.; Langendijk, Johannes A.

doi:10.1016/j.ijrobp.2009.08.042

Cited by 47 publications

(40 citation statements)

References 29 publications

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“…Vergeer et al reported a series of 123 patients who were treated with surgery followed by ipsilateral RT for tonsil tumors >1 cm from the midline. 8 A total of 7 contralateral recurrences occurred, with 4 reported in patients with N2b disease. N2b disease was found to be a significant predictor of contralateral recurrence in this study.…”

Section: Discussionmentioning

confidence: 98%

Comparison of unilateral versus bilateral intensity‐modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil

Chin

Rao

Hwang

et al. 2017

Cancer

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Section: Discussionmentioning

confidence: 98%

Comparison of unilateral versus bilateral intensity‐modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil

Chin

Rao

Hwang

et al. 2017

Cancer

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“…This finding is corroborated by data from the radiation literature suggesting that patients with involved lymph nodes are more likely to have contralateral neck involvement. 16,[34][35][36] The presence of lymphatic metastases may result in lymphatic re-routing that would predispose patients with lateralized tumors to contralateral metastases.…”

Section: Discussionmentioning

confidence: 99%

Lymphatic mapping with SPECT‐CT for evaluation of contralateral drainage in lateralized oropharyngeal cancers using an awake injection technique

et al. 2019

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Background: Risk of contralateral nodal metastases in oropharyngeal squamous cell carcinoma (OPSCC) is currently based on clinical risk factors. We propose lymphatic mapping with single photon emission computed tomography (SPECT-CT) for tumor-specific delineation of lymphatic drainage to guide treatment.Methods: Retrospective review of lymphatic drainage patterns in cT1-2 OPSCC and contralateral cN0 neck with a nonoperative, awake injection of 99 m-Tc sulfur colloid and SPECT-CT. Results: Ten patients were reviewed. Primary sites included tonsil (n = 8, 80%) and tongue base (n = 2, 20%). All patients tolerated awake injections with no complications. Nine patients (90%) demonstrated satisfactory migration of radiotracer to neck node(s) with seven (78%) to the ipsilateral lateral neck, one (11%) to the ipsilateral lateral neck and retropharynx, and one (11%) to bilateral lateral neck nodes.Conclusions: Characterization of lymphatic drainage in OPSCC is feasible using a nonoperative injection technique and SPECT-CT. Drainage to the contralateral neck is rare, warranting further study to tailor treatment appropriately. K E Y W O R D Sawake injection, lymphoscintigraphy, neck dissection, oropharyngeal squamous cell carcinoma, sentinel lymph node biopsy, SPECT-CT, transoral robotic surgery

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“…Treatment of the neck can be unilateral for well lateralized lesions (i.e. buccal mucosa), in absence of cN2-N3 ipsilateral neck nodes [ 85 ] (see Table 6 ).…”

Section: Methodsmentioning

confidence: 99%

Technical guidelines for head and neck cancer IMRT on behalf of the Italian association of radiation oncology - head and neck working group

Merlotti

Alterio²,

Vigna‐Taglianti

et al. 2014

Radiat Oncol

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Performing intensity-modulated radiotherapy (IMRT) on head and neck cancer patients (HNCPs) requires robust training and experience. Thus, in 2011, the Head and Neck Cancer Working Group (HNCWG) of the Italian Association of Radiation Oncology (AIRO) organized a study group with the aim to run a literature review to outline clinical practice recommendations, to suggest technical solutions and to advise target volumes and doses selection for head and neck cancer IMRT. The main purpose was therefore to standardize the technical approach of radiation oncologists in this context. The following paper describes the results of this working group. Volumes, techniques/strategies and dosage were summarized for each head-and-neck site and subsite according to international guidelines or after reaching a consensus in case of weak literature evidence.

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Ipsilateral Irradiation for Oral and Oropharyngeal Carcinoma Treated With Primary Surgery and Postoperative Radiotherapy

Cited by 47 publications

References 29 publications

Comparison of unilateral versus bilateral intensity‐modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil

Comparison of unilateral versus bilateral intensity‐modulated radiotherapy for surgically treated squamous cell carcinoma of the palatine tonsil

Lymphatic mapping with SPECT‐CT for evaluation of contralateral drainage in lateralized oropharyngeal cancers using an awake injection technique

Technical guidelines for head and neck cancer IMRT on behalf of the Italian association of radiation oncology - head and neck working group

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