Irbesartan has a curative effect on lipopolysaccharide-induced cardiotoxicity by antioxidant and antiapoptotic pathways

Tepebaşı, Muhammet Yusuf; Aşçı, Halil; COŞAN, Samet; Sevük, Mehmet Abdulkadir; KARAKUYU, Nasıf Fatih; Özmen, Özlem

doi:10.1016/j.repc.2023.03.018

Cited by 8 publications

(1 citation statement)

References 38 publications

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“…On the third day to create an inflammatory state, a single dose of Lps (048K4126, Sigma Aldrich, USA) dissolved in saline, was given i.p. into the right inguinal region [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

Ozcan,

Savran,

Kumbul Doguc

et al. 2024

Heliyon

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“…On the third day to create an inflammatory state, a single dose of Lps (048K4126, Sigma Aldrich, USA) dissolved in saline, was given i.p. into the right inguinal region [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

Ozcan,

Savran,

Kumbul Doguc

et al. 2024

Heliyon

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Protective effect of irbesartan against hepatic ischemia–reperfusion injury in rats: role of ERK, STAT3, and PPAR-γ inflammatory pathways in rats

El-Marasy,

Mostafa,

Mabrok

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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This study aimed to elucidate the possible hepatocellular protective role of irbesartan during hepatic ischemia–reperfusion injury (HIRI) and the probable underlying mechanisms. Wistar rats were allocated into four groups: sham; HIRI (control); irbesartan (50 mg/kg) + HIRI; irbesartan (100 mg/kg) + HIRI; irbesartan + GW9662 (1 mg/kg, i.p.) + HIRI. Rats pretreated orally with irbesartan or vehicle for 14 days underwent 45-min hepatic ischemia followed by 60-min reperfusion. Irbesartan preconditioning diminished alanine transaminase (ALT) and aspartate transaminase (AST) serum levels, and reduced extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3). Irbesartan decreased proapoptotic BAX (bcl-2-like protein 4), increased anti-apoptotic B-cell lymphoma 2 (BCL2) hepatic content, and thereby reduced BAX/BCL2 ratio. Moreover, irbesartan preconditioning reduced autophagy-related proteins Beclin1 and LC3 II, and elevated p62 (protein responsible for autophagosome degradation). It elevated proliferator-activated receptor γ (PPAR-γ), and reduced tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) hepatic gene expression. Also, hepatic protein expressions of nuclear factor kappa-B p65 (NF-κB p65) and caspase-3 were lessoned by irbesartan pretreatment in HIRI rats. However, GW9662 abrogated irbesartan's effect on HIRI. The protective effect of irbesartan on HIRI may be mediated by alleviation of ERK, STAT3, and PPAR-γ inflammatory pathways, exerting anti-apoptotic and anti-autophagic effects in HIRI in rats.

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Potential ameliorative effect of Dapagliflozin on systemic inflammation-induced cardiovascular injury via endoplasmic reticulum stress and autophagy pathway

Tepebasi,

Selcuk,

Taner

et al. 2024

Mol Biol Rep

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Irbesartan has a curative effect on lipopolysaccharide-induced cardiotoxicity by antioxidant and antiapoptotic pathways

Cited by 8 publications

References 38 publications

Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

Dexpanthenol ameliorates lipopolysaccharide-induced cardiovascular toxicity by regulating the IL-6/HIF1α/VEGF pathway

Protective effect of irbesartan against hepatic ischemia–reperfusion injury in rats: role of ERK, STAT3, and PPAR-γ inflammatory pathways in rats

Potential ameliorative effect of Dapagliflozin on systemic inflammation-induced cardiovascular injury via endoplasmic reticulum stress and autophagy pathway

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