Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance

Kathiravan, Subban; Nicholls, Ian A.

doi:10.1039/d3ra02031b

RSC Adv.

2023

DOI: 10.1039/d3ra02031b

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Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance

Subban Kathiravan

Ian A. Nicholls

Abstract: Efficient iridium(iii) catalysed C2-selective methylation of indoles through the formation of a five-membered metallocycle is explored.

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2024

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MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

Le,

Nguyen

et al. 2024

ChemistrySelect

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Herein, we present an efficient, one‐pot reaction for accessing 3‐benzylated indoles via the coupling of benzyl alcohols with indoles under heterogeneous catalysis by manganese ferrite (MnFe2O4) nanoparticles. Notably, this reaction, for the first time, employs MnFe2O4 nanoparticles prepared using a simple grinding method. The high compatibility of MnFe2O4 nanoparticles enables a broad substrate scope and high regioselectivity. Moreover, this approach offers several attractive highlights including the use of a recyclable oxide catalyst and green and cost‐effective alkylating reagents under solvent‐free conditions.

show abstract

MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

Le,

Nguyen

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

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Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance

Abstract: Efficient iridium(iii) catalysed C2-selective methylation of indoles through the formation of a five-membered metallocycle is explored.

Cited by 1 publication

References 69 publications

MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

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Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance

Abstract: Efficient iridium(iii) catalysed C2-selective methylation of indoles through the formation of a five-membered metallocycle is explored.

Cited by 1 publication

References 69 publications

MnFe2O4 Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

MnFe2O4 Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

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Product

Resources

About

MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions

MnFe₂O₄ Nanoparticles‐Catalyzed C3‐Alkylation of Indoles with Benzyl Alcohols under Solvent‐Free Conditions