Iris Melanoma

Singh, Arun D.; Damato, Bertil

doi:10.1007/978-3-030-17879-6_10

Cited by 3 publications

(6 citation statements)

References 109 publications

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“…Emami et al reported that if the lens delivered a dose of more than 10 Gy, the risk of cataracts is 5% within/after 5 yr (TD 5/5) for conventional prescription [ 15 ]. According to M. Kamrava et al, if a cumulative dose is delivered to the lens of 24 Gy or more, the 5-year cumulative incidence of radiation-induced cataracts was 92% compared with 65% in those receiving less than 12 Gy [ 16 ]. Radiation-induced cataracts are usually treated with standard surgical techniques to improve vision.…”

Section: Discussionmentioning

confidence: 99%

Scanning methodology for contact lens-type ocular in vivo dosimeter (CLOD) dosimetry applying a silicone material

et al. 2022

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Purpose Contact lens-type ocular in vivo dosimeters (CLODs) were recently developed as the first in vivo dosimeter that can be worn directly on the eye to measure the dose delivered to the lens during radiotherapy. However, it has an inherent uncertainty because of its curved shape. Newton’s ring effect inevitably occurs because the spacing between the glass window and the active layer is not constant. Furthermore, it involves a large uncertainty because the objective of the CLOD with such morphological characteristics is to measure the dose delivered to an out-of-field lens. In this study, we aimed to investigate the effects of various compensating materials on the sensitivity, accuracy, and uniformity of analysis using a curved CLOD. We developed a new scanning methodology that involves applying a compensating material to reduce the uncertainty caused by the air gap. Methods Four compensating materials—Dragon Skin™ 10 (DS), a transparent silicon material, SORTA-Clear™ 40 (SC), optical grease (OG), and air (no compensating material)—were used in this study. The CLOD was scanned in the reflective mode and transmission mode using each compensating material. We then examined the sensitivity, accuracy, and scan uniformity to evaluate the scanning methodology using compensating materials. Results The increase in sensitivity was the highest for OG compared to that for air in the reflective mode. On average, the sensitivity in the reflective mode was higher than that in the transmission mode by a factor of 2.5 for each dose. Among the four compensating materials, OG had the smallest uncertainty. Therefore, the best scan uniformity was achieved when OG was used. Conclusions Scanning methodology was proposed in which a compensating material is applied for a curved lens-type dosimeter. Our results show that OG is the most suitable compensating material to obtain the best accuracy of dose analysis. Following this methodology, the scan uncertainty of curved dosimeters significantly decreased.

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Section: Discussionmentioning

confidence: 99%

Scanning methodology for contact lens-type ocular in vivo dosimeter (CLOD) dosimetry applying a silicone material

et al. 2022

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“…W obrębie tęczówki występuje on rzadziej niż w naczyniówce i ciele rzęskowym. Przednie położenie tego odcinka błony naczyniowej, umożliwia szybszą diagnozę oraz rozpoczęcie leczenia w mniej zaawansowanym stadium nowotworu, co w porównaniu z pozostałymi odcinkami, przekłada się na korzystny wynik terapii i lepszą jakość życia pacjentów [3,4,5]. W wielu przypadkach czerniaka tęczówki, nie obserwuje się jednak żadnych objawów [6].…”

Section: Wstępunclassified

“…Diagnostykę w kierunku czerniaka tęczówki rozpoczyna się od wnikliwej oceny zmiany z użyciem lampy szczelinowej. W następnej kolejności wykonywane są badania obrazowe, takie jak UBM (USG przedniego odcinka gałki ocznej ) i AS-OCT (optyczna koherentna tomografia przedniego odcinka gałki ocznej), które umożliwiają dokładną ocenę wielkości guza oraz głębokości nacieku [5]. UBM pomaga odróżnić lite zmiany tęczówki od torbieli, a także uwidacznia zajęcie kąta komory przedniej i ciała rzęskowego.…”

Section: Rozpoznanie I Różnicowanieunclassified

“…Małe znamiona, nie wykazujące cech wzrostu, poddawane są obserwacji. W przypadku rozpoznania czerniaka, który się powiększa, kiedy jego średnica jest jeszcze niewielka, w zależności od zajętych struktur, wykonuje się zabieg częściowej irydektomii, irydotrabekulektomii lub irydocyklektomii, z zachowaniem odpowiedniego marginesu 1-2 mm zdrowych tkanek [5,20]. Postęp w mikrochirurgii, jaki dokonał się w ostatnich latach zapewnia aktualnie skuteczne, doszczętne i obarczone niewielką ilością powikłań leczenie zabiegowe.…”

Section: Leczenieunclassified

“…W niektórych przypadkach konieczne jest poszerzenie zabiegu o usunięcie okolicznych struktur. Enukleacja jest najbardziej inwazyjną i ostateczną metodą leczenia [4,5].…”

Section: Leczenieunclassified

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Clinical features and management of iris melanoma - a systematic review

Sereda

Nieścior

Metelska

et al. 2022

J Educ Health Sport

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Introduction and purpose Uveal melanoma is the most common primary intraocular malignancy in adults. Most of them arise in the choroid and ciliary body, whereas 2-5 % of the cases are located to the iris. Nevertheless, during the last few decades the incidence of this neoplasm has been increasing. The aim of the study is to discuss the risk factors, clinical features and methods of diagnosis and treatment of iris melanoma. Description of the state of knowledge Iris melanomas vary in their shape, size, degree of pigmentation and clinical behavior and most commonly present as a nodular tumor located in the lower temporal iris quadrant. This localisation is linked to exposure to solar radiation, which among light-colored iris, skin color and pre- existing iris naevus, is a risk factor for this malignancy. Gender predilection for the development of iris melanoma is unclear, however, some studies indicate a predominance of female patients. The most common clinical symptoms are growth of a pre-existing naevus, detection of new, dark lesion, pain secondary to elevated IOP and blurred vision. Due to anterior location of this site of uvea, early diagnosis and treatment is possible. Slit-lamp examination, gonioscopy, and ultrasound biomicroscopy (UBM) allow staging of the tumor to guide the most appropriate treatment. As many primary iris lesions have a benign prognosis, surgical resection or radiotherapy is efficient way of treatment and allows good local tumor control. Summary Iris melanoma is least frequent of all uveal melanomas and usually presents as variably pigmented, elevated, solitary lesion. When there is a clinical suspicion of malignancy slit- lamp examination and UBM should be performed. When early diagnosed it can be successfully treated.

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Clinical outcomes of Modified Collaborative Ocular Melanoma Study IRIS plaques for treatment of iris, iridociliary, and ciliary body melanoma

Pulido

Deufel

et al. 2020

Eye

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Background/objectives To report clinical outcomes of modified Collaborative Ocular Melanoma Study IRIS (COMS IRIS) plaques for treatment of iris, iridociliary, and ciliary body melanoma. Subjects/methods Retrospective, single-centre cohort study of iris melanoma treated with COMS IRIS plaque radiotherapy from July 26, 2010 to October 15, 2018. Medical records were reviewed for demographics, tumour features, treatment parameters, and clinical outcomes. Results There were 22 cases, diagnosed at mean age of 59 years (median 65, range 21-85 years) with female sex in 14 (64%). Presenting tumour features included Snellen visual acuity (VA) ≥ 20/40 in 18 (82%) cases, mean largest tumour basal diameter 4.7 mm (median 3.9, range 2.3-13.8 mm) and thickness 1.7 mm (median 1.6 mm, range 0.8-3.9 mm), iris stromal seeding in 3 (14%) cases, angle seeding in 16 (73%), and ciliary body involvement in 13 (59%). After mean follow-up of 51 months (median 44, range 4-113 months), Snellen VA was ≥20/40 in 14 (64%) cases, with local tumour recurrence in 2 (9%), and enucleation in 2 (9%). The 3-year Kaplan-Meier estimated risk of local tumour recurrence was 7%. The most common radiation side effects were cataract in 17 (77%) patients and dry eye in 5 (23%). Systemic metastasis occurred in no cases, and 1 (5%) non-melanoma-related death due to natural causes was observed at last follow-up. Conclusions COMS IRIS plaques are effective for treatment of iris, iridociliary, and ciliary body melanoma with modest VA outcomes and low frequency of local tumour recurrence, enucleation, radiation side effects, and systemic metastasis.

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Iris Melanoma

Cited by 3 publications

References 109 publications

Scanning methodology for contact lens-type ocular in vivo dosimeter (CLOD) dosimetry applying a silicone material

Scanning methodology for contact lens-type ocular in vivo dosimeter (CLOD) dosimetry applying a silicone material

Clinical features and management of iris melanoma - a systematic review

Clinical outcomes of Modified Collaborative Ocular Melanoma Study IRIS plaques for treatment of iris, iridociliary, and ciliary body melanoma

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