Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

Moreno-Navarrete, José María; Ortega, Francisco; Serrano, Marta; Guerra, Ester; Pardo, Gerard; Tinahones, Francisco J.; Ricart, Wifredo; Fernández-Real, José Manuel

doi:10.1210/jc.2012-2749

Cited by 694 publications

(697 citation statements)

References 22 publications

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“…A limitation of the current study and previous is that a wide range of circulating irisin levels have been reported (Choi et al, 2013;Huh et al, 2012;Moreno-Navarrete et al, 2013;Stengel et al, 2012;Zhang et al, 2013), even through a same study (Moreno-Navarrete et al, 2013). This range of detection could be the result of variations on target epitopes among manufacturers, as no consensus exists on which part or parts of this membrane protein are soluble, nor does a consensus on the mechanism of irisin secretion exist (Roca-Rivada et al, 2013).…”

Section: Discusionmentioning

confidence: 71%

“…Surprisingly, a recent report has revealed a significant decrease in circulating irisin and adipose and muscle tissue gene expression levels in obesity, suggesting that irisin is inversely associated with different adiposity markers (Moreno-Navarrete et al, 2013). On the other hand, low circulating irisin levels were associated with chronic kidney disease (Wen et al, 2013), intrahepatic triglycerides content in obese adults with non alcoholic fatty liver disease (Zhang et al, 2013) and with type 2 diabetes (Choi et al, 2013;Liu et al, 2013).…”

Section: Discusionmentioning

confidence: 97%

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Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

129

117

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Objective: The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. The objective of this work was to evaluate whether circulating human irisin levels are modulated by body size and changes in adiposity during an energy restriction treatment and the subsequent weight regain.Methods: A group of 94 obese patients (50 men, 44 women; 49.4 6 9.4 years; BMI 35.6 6 4.5 kg/m 2 ) participated in a weight loss program following an 8-week hypocaloric diet (230% energy expenditure) with a weight maintenance follow-up. The patients were evaluated at 0, 8, and 24 weeks after starting treatment. In addition, 48 normal-weight subjects (16 men, 32 women; 35.71 6 8.8 years; BMI 22.9 6 2.2 kg/m 2 ) participated as controls. Plasma irisin, body weight, body composition, and hormones controlling energy homeostasis were measured.Results: Irisin levels were higher in obese subjects (353.1 6 18.6 ng/mL) than in those of normal-weight (198.4 6 7.8 ng/mL; P 0.001) and were also higher in men (340.9 6 20 ng/mL) than in women (267.6 6 12 ng/mL; P < 0.05). Moreover, irisin plasma levels were significantly correlated with high levels of direct and indirect adiposity markers, such as weight, BMI, waist circumference, and fat mass, as measured by bioimpedance, but not with height or leptin levels. Interestingly, irisin levels paralleled body weight reduction after the dietary treatment (week 8) and again returned to the baseline levels at 24 weeks in those patients regaining the lost weight.Conclusions: Irisin strongly reflects body fat mass, suggesting that the irisin circulating levels are conditioned by adiposity level. Am. J. Hum. Biol. 26:198-207, 2014.

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Section: Discusionmentioning

confidence: 71%

Section: Discusionmentioning

confidence: 97%

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

129

117

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“…Studies have reported that irisin is related to BMI; however, irisin was not significantly correlated with BMI in other studies [23,24]. The circulating irisin levels have been shown to be negatively correlated with BMI [25][26][27], whereas some reports suggested that irisin concentrations were positively associated with BMI [20,28]. Moreover, although a few studies have demonstrated that there is no direct relationship between irisin and BMI, their results support the hypothesis of a positive correlation between irisin and BMI.…”

Section: Discussionmentioning

confidence: 85%

“…Increases in BMI during childhood are generally attributed to the lean rather than the fat component of BMI until the end of puberty [32]. MorenoNavarrete et al [25] showed that muscle FNDC5 gene expression was positively associated with BMI, but FNDC5 gene expression in human adipose tissue was inversely associated with obesity. These authors also suggested that the stimulation of browning on adipocytes may enhance irisin production.…”

Section: Discussionmentioning

confidence: 99%

Irisin is a biomarker for metabolic syndrome in prepubertal children

et al. 2018

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Abstract. The aim of the present study was to evaluate the association of irisin with obesity and metabolic syndrome (MetS) in Korean prepubertal children. A total of 96 children and adolescents aged 6 to 10 years (56 males) were included in this study. Subjects were divided into 3 groups: normal weight (n = 54), overweight (n = 16), and obese (n = 26). In the subgroup analyses, overweight/obese children were further divided based on their MetS status (with MetS vs. without MetS). Children with obesity tended to exhibit a lower mean irisin concentration compared to those with normal weight (p = 0.028). Using Pearson's correlation coefficient to compare all the children in the study, there was a significant inverse correlation between irisin and body mass index (BMI) standard deviation scores (SDS) (r = -0.210, p = 0.041), waist circumference SDS (r = -0.203, p = 0.049), and glucose (r = -0.296, p = 0.004). In the subgroup analyses of overweight/obese children, irisin exhibited a significant inverse correlation with glucose (r = -0.507, p = 0.001) and triglycerides (r = -0.331, p = 0.033). Children with MetS exhibited lower irisin concentrations than those without MetS (14.70 ng/mL vs. 22.02 ng/mL, p = 0.001), and these associations were significant after adjusting for age, gender, and BMI SDS (14.51 ng/mL vs. 22.06 ng/mL, p = 0.002). The irisin level of 15.43 ng/mL was determined to be a possible cutoff to distinguish children with metabolic syndrome from overweight/obese children, with a sensitivity of 75% and a specificity of 94% (p < 0.001). Our results suggest that decreased irisin levels may be associated with MetS in prepubertal children and that irisin might be a biomarker for MetS in prepubertal children. WITH an increasing population of overweight and obese children, metabolic complications associated with being overweight/obese, such as insulin resistance, hypertension and dyslipidemia, have become a major public health concern [1]. The incidence of childhood metabolic syndrome (MetS), which is closely related to insulin resistance, is defined as a clustering of abdominal obesity, hypertension, dyslipidemia and glucose intolerance and is increasing around the world, including in Korea [2]. The clustering of metabolic risk factors begins in childhood [3], and these multiple risk factors tend to persist from childhood into adulthood [4]. Childhood MetS is a risk factor for MetS, cardiovascular diseases and Submitted Jun. 15, 2017; Accepted Aug. 16, 2017 as EJ17-0260 Released online in J-STAGE as advance publication Sep. 12, 2017 Correspondence to: Il Tae Hwang, MD, PhD, Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150 Seongan-ro, Gangdong-gu, Seoul, Korea, 05338 E-mail: ithwang83@hallym.or.kr type 2 diabetes mellitus (T2DM) in adulthood [5]. It is therefore important to identify early MetS in children and adolescents.Recently, adipokines (i.e., adipocyte-secreted proteins) and myokines (i.e., myocyte-secreted proteins) have been s...

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“…FNDC5 is expressed in a broad range of human tissues (Huh et al 2012) and its steady-state expression levels in muscle seems to correlate with its levels in adipose tissue (Moreno-Navarrete et al 2013). Speculatively, this may mean that FNDC5 transcription is regulated in a systemic manner.…”

Section: Introductionmentioning

confidence: 99%

Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women

Ellefsen¹,

Vikmoen²,

Slettaløkken³

et al. 2014

Eur J Appl Physiol

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This file was dowloaded from the institutional repository Brage NIH -brage.bibsys.no/nih Ellefsen, S., Vikmoen, O., Slettaløkken, G., Whist, J. E., Nygård, H., Hollan, I.... Rønnestad, B. (2014). Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women. MethodsEighteen untrained women performed 12 weeks of progressive whole body heavy strength training, with measurement of strength, body composition, expression of irisin-related genes (FNDC5 and PGC1α) in two different skeletal muscles, and levels of serum-irisin and -thyroid hormones, before and after the training intervention. ResultsThe strength training intervention did not result in changes in serum-irisin or muscle FNDC5 expression, despite considerable effects on strength, lean body mass (LBM) and skeletal muscle phenotype. However, our data indicate that training affects irisin biology in a LBM-dependent

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Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

Abstract: Decreased circulating irisin concentration and FNDC5 gene expression in adipose tissue and muscle from obese and type 2 diabetic subjects suggests a loss of brown-like characteristics and a potential target for therapy.

Cited by 694 publications

References 22 publications

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Irisin is a biomarker for metabolic syndrome in prepubertal children

Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women

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