Iron-Based Nanoparticles Applied to Evaluate MRI Diagnosis and Treatment of Liver Cancer Treated with Apatinib

Abstract

Objective: To investigate the value of iron-based nanoparticles in evaluating the magnetic resonance imaging (MRI) diagnosis and treatment of liver cancer treated with apatinib. Methods: Apatinib treatment and MRI were performed in patients with primary liver cancer. The characteristics of liver tissue sections and biodistribution in mice after injection of Fe2O3-PEG and iron oxide nanoparticles (Fe2O3-pep) were analyzed, and the MRI characteristics and magnetic resonance signals of Fe2O3-PEG and Fe2O3-pep nanoparticles were compared. Results: Fe2O3-PEG and Fe2O3-pep had little effect on the activity of human normal hepatocytes. There was no significant difference in liver tissue sections between mice injected with Fe2O3-PEG and Fe2O3-pep nanoparticles. The Fe2O3-PEG and Fe2O3-pep in the liver organs of mice were 11.3 and 9.7, which were significantly higher than those in other organs. At 12 hours and 24 hours after injection of Fe2O3-pep and Fe2O3-PEG nanoparticles, the signal at the tumor site decreased on T2WI images, the maximum contrast of magnetic resonance images was enhanced at 12 hours after injection, and the signal decrease was more significant in the group injected with Fe2O3-pep nanoparticles. Conclusion: Fe2O3-pep has higher tumor targeting and has positive application value in evaluating MRI diagnosis and treatment of liver cancer.