Iron deficiency and sleep disordered breathing in children—Cause or effect?

Kerstein, Ryan; Stimpson, Paul; Caulfield, Helen; Ellis, Gareth

doi:10.1016/j.ijporl.2008.10.023

Cited by 11 publications

(13 citation statements)

References 19 publications

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“…In recent years, the association between iron deficiency and sleep disorders has received growing attention in the scientific literature [ 155 ]. Low levels of iron have been associated with restless legs syndrome/periodic limb movement disorder (RLS/PLMD) [ 156 ] and RLS-induced insomnia [ 157 , 158 ], parasomnias [ 159 ], sleep disordered breathing [ 160 ], attention deficit and hyperactivity disorder (ADHD) [ 161 ], and “restless sleep disorder”, a newly proposed diagnosis [ 162 ].…”

Section: Oral Over-the-counter Medicinesmentioning

confidence: 99%

Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments

et al. 2020

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Autism Spectrum Disorders (ASD) are lifelong neurodevelopmental conditions characterized by abnormal social interaction, communication, and behavior. Sleep disturbances represent a common comorbidity in children and adolescents with ASD, with prevalence ranging from 50 to 80%. It has been proved that sleep disruption worsens the symptoms of autism and results in challenging behaviors. Improving sleep should therefore be a primary therapeutic goal. Treatment options range from lifestyle modifications to pharmacological therapy. Several reviews have been written on pharmacological treatments, but very few on the beneficial effects of non-pharmacological interventions, over-the-counter drugs, and nutritional supplements. This study consists of a narrative review of the literature, presenting the available evidence on the following treatments: sleep education, behavioral interventions, complementary and alternative medicine (special mattresses and blankets, massage, aromatherapy, yoga, physical activity), and commonly used over-the-counter medications and supplements (antihistamines, melatonin, tryptophan, carnosine, iron, vitamins, and herbal remedies). For some treatments—such as melatonin and behavioral interventions—effectiveness in ASD is well established in the literature, while other interventions appear of benefit in clinical practice, even if specific studies in children and adolescents with ASD are lacking. Conversely, other treatments only seem to show anecdotal evidence supporting their use.

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Section: Oral Over-the-counter Medicinesmentioning

confidence: 99%

Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments

et al. 2020

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“…2 ciency are reported to be common. 15 We therefore investigated the relationship between transferrin saturation, α-thalassemia genotype, and nocturnal oximetry in pediatric SCA patients with the hypothesis that those with evidence of iron deficiency would have lower SpO 2 .…”

Section: Sickle Cell Anemia: Iron Availability and Nocturnal Oximetrymentioning

confidence: 99%

Sickle Cell Anemia: Iron Availability and Nocturnal Oximetry

Cox

L’Esperance

Makani

et al. 2012

Journal of Clinical Sleep Medicine

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“…SDB may lead to numerous morbidities such as neurocognitive disorders, craniofacial growth abnormalities, enuresis and cardiovascular problems if not treated [1]. The The published literature documented the increased incidence of anemia in patients underwent adenotonsillectomy [3,12,13] and improved anemia after operations without any iron supplementation [11]. Unfortunately, there is no enough data to explain pathogenesis of impaired iron metabolism in these patients.…”

Section: Discussionmentioning

confidence: 99%

“…Kerstein et al [13] reviewed 94 children undergoing adenotonsillectomy. They categorized the study population according to age; Group A: 0-2 years, Group B: 2-6 years, Group C: above 6 years.…”

Section: Discussionmentioning

confidence: 99%

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Is anemia in children with sleep disordered breathing actually a consequence of chronic disease?

Dündar¹,

Akcan²,

Uluat³

et al. 2018

The European Research Journal

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Objectives. We aimed to investigate iron metabolism and laboratory findings of anemia in children undergoing adenotonsillectomy for sleep disordered breathing. Methods. Consecutive children undergoing adenoidectomy/adenotonsillectomy for sleep disordered breathing between January 2013 and January 2015 were investigated. Routine preoperative blood tests including blood count and iron studies were analyzed. Subgroup analyses were performed addressing to the severity of sleep disordered breathing, age and duration of symptoms. Results were compared between subgroups and normal values. Results. The study included 171 children. The mean age was 5.44 ± 2.62 years. The mean hemoglobin level was 11.87 ± 1.125 gr/dL and 24 (14%) out of 171 patients had anemia (< 11 gr/dL). The mean ferritin levels were 23.23 ± 17.27 µg/L and 21.27 ± 15.44 µg/L in patients with anemia and non-anemic patients, respectively (p = 0.572). Ferritin levels decreased in only 8 (33%) out of 24 patients with anemia. The mean age, body mass index, hematocrit, mean corpuscular volume, unsaturated iron binding capacity and serum iron levels decreased in patients with anemia. The rate of anemia significantly increased in children less than or equal to 3 years of age (p = 0.020). There was no significant association between hemoglobin levels and sleep disordered breathing clinical score or duration of symptoms. Conclusion. The association between low iron status and sleep disordered breathing has previously published. Unfortunately, the type of anemia is still unclear. Our results supposed that the anemia of chronic disease secondary to chronic inflammatory process might play a role in pathogenesis of anemia in patients with sleep disordered breathing.

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Iron deficiency and sleep disordered breathing in children—Cause or effect?

Cited by 11 publications

References 19 publications

Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments

Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments

Sickle Cell Anemia: Iron Availability and Nocturnal Oximetry

Is anemia in children with sleep disordered breathing actually a consequence of chronic disease?

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