Iron in Child Obesity. Relationships with Inflammation and Metabolic Risk Factors

Bouglé, Dominique; Brouard, J.

doi:10.3390/nu5062222

Cited by 20 publications

(18 citation statements)

References 44 publications

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“…Studies from West show much lower prevalence of iron deficiency state in obese children ranging from 2% to 15.6% [6,7]. This is contrast to studies from Asian sub-continent, where combined prevalence of ID and IDA is noted to be around 36-42% [8,9].…”

Section: The Commonest Infection Was Tuberculosis (Tb)contrasting

confidence: 48%

Research Letters

et al. 2018

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Section: The Commonest Infection Was Tuberculosis (Tb)contrasting

confidence: 48%

Research Letters

et al. 2018

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“…Currently, there is controversy on the association of iron concentrations in the body and its metabolism with the development of the MetS in both genders, both in adults and adolescents. Iron is usually considered as an independent factor for the development of MetS and, thus, not in all cases associated with ceruloplasmin levels [36][37][38][39][40][41].…”

Section: Non Mets Metsmentioning

confidence: 99%

Predictive value of ceruloplasmin for metabolic syndrome in adolescents

et al. 2016

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The metabolic syndrome (MetS) is precisely defined and the cardiovascular risk associated with the clustering of its components has been demonstrated in adults. However, data on children and adolescents are still scarce, in part, because of difficulties in transposing the definition from adults. The identification of risk factors for the development of MetS at an early age is essential for prevention purposes with low‐grade inflammation acting as a determinant for the association among the MetS components. The aim of this study was to investigate the associations of the MetS with systemic markers of inflammation and ceruloplasmin in a population of adolescents. The present is a cross‐sectional study whose sample population consisted of 976 adolescents, 13.2 ± 1.2 years of age. Interleukin‐6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) were determined by ELISA. High‐sensitivity C‐reactive protein (hs‐CRP) was determined by a solid‐phase chemiluminiscent immunometric assay. Ceruloplasmin was measured by immunoturbidimetry. MetS adolescents exhibited higher levels of TNF−α, IL‐6, CRP, and ceruloplasmin compared to non‐MetS individuals. TNF−α, IL‐6, and CRP showed strong correlations with the MetS components and insulin resistance but not relevant predictive values according to ROC curves (AUC values 0.544‐ 0.555). In contrast, ceruloplasmin only showed significant correlations in non‐Mets individuals, but exhibited a very high predictive value (AUC=0.941, P < 0.001). The determination of serum ceruloplasmin in adolescents might be a useful tool to identify patients with the highest risk of future cardiovascular disease. © 2016 BioFactors, 42(2):163–170, 2016

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“…A few decades ago, Sullivan proposed the iron hypothesis, suggesting that iron metabolism contributes to inflammation and oxidative stress, which may lead to atherosclerosis and other cardiovascular diseases [5, 6]. In addition, previous epidemiological studies have reported that iron metabolic alteration, such as ferritin or serum iron, which are known as indicators of iron storage, are associated with oxidative stress and adverse lipid concentration in children and adults [7–9]. Moreover, several studies have reported that transferrin and soluble transferrin receptor (sTfR) are associated with obesity, metabolic syndrome and other cardiovascular risk factors in adults and children [10–12].…”

Section: Introductionmentioning

confidence: 99%

Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study

Zhu

Xiao

et al. 2019

Lipids Health Dis

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BackgroundInformation on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association between iron metabolism and dyslipidaemia risk.MethodIn total, 1866 children and adolescents aged 7–18 were enrolled in this study, including 912 boys and 954 girls. In this cross-sectional study, parameters for anthropometry, lipids and iron metabolism including transferrin, soluble transferrin receptor (sTfR), ferritin and serum iron (SF) were evaluated. Data regarding demographic characteristics, diet, and physical activity were collected by self-reported questionnaires.ResultsThe prevalence of dyslipidaemia and iron deficiency in children and adolescents increased based on BMI categories (both P < 0.05) and were 58.3 and 8.9% in subjects with obesity, respectively. The lowest SF and the highest ferritin levels were observed in subjects who were obese (both P < 0.001). Subjects with dyslipidaemia had lower SF, transferrin and sTfR levels by different BMI categories, and those who were obese had higher ferritin levels (all P < 0.05). Most importantly, higher concentrations of transferrin and sTfR were related to lower dyslipidaemia risk (OR for transferrin: 0.49, 95% CI: 0.33–0.71; OR for sTfR: 0.68, 95% CI: 0.46–0.99).ConclusionsA downward trend in SF level by BMI categories and the highest ferritin level in subjects with obesity suggested that iron storage was associated with BMI in children and adolescents. Moreover, an inverse relationship was observed between transferrin and sTfR concentrations and dyslipidaemia risk in children with different BMI.

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Iron in Child Obesity. Relationships with Inflammation and Metabolic Risk Factors

Cited by 20 publications

References 44 publications

Research Letters

Research Letters

Predictive value of ceruloplasmin for metabolic syndrome in adolescents

Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study

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