Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy

Lee, Jun Young; Yoo, Dongwon; Ling, Daishun; Cho, Mi Hyeon; Hyeon, Taeghwan; Cheon, Jinwoo

doi:10.1021/acs.chemrev.5b00112

Cited by 889 publications

(703 citation statements)

References 633 publications

(1,320 reference statements)

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“…[1][2][3][4][5][6] Recent advances in block copolymer-based self-assembly [7][8][9] have led to the development of various magnetic DDS vehicles [1][2][3][4][5][6] such as polymeric nanocarriers into which prodrugs are often co-encapsulated with magnetic nanoparticles (MNPs), and these nanocarriers serve to shield the drug and to enable its magnetically guided imaging and local release in response to an alternating magnetic field (AMF).…”

Section: Introductionmentioning

confidence: 99%

“…However, the synthesis of MNPs with desirable magnetic properties for magnetic DDS platforms requires numerous steps to control the particles' core, diameter, anisotropy, suspension composition and surface coating, [1][2][3][4][5][6][7][8][9] and requires considerable care to avoid adverse effects in vivo. For example, an excessive dose of MNPs can cause oxidative stress-induced cell injury, 10,11 and slow degradation can lead to accumulation in the liver and other organs, 5,12 resulting in potentially fatal effects such as cardiovascular damage, blood clots and hypersensitivity.…”

Section: Introductionmentioning

confidence: 99%

“…Compared with traditional MNP-based methods that require additional co-loading processes of drug reagents, [1][2][3][4][5][6][7][8][9] the Fe(salen)-based system is unprecedented in that a single agent provides both the magnetic properties and anticancer activity. In other words, the Fe(salen) metal complexes, which have been used in the last few decades as asymmetric catalysts [17][18][19][20] and molecular magnets, 21,22 can be employed as magnetically guided anticancer agents.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a single-drug anticancer platform

et al. 2017

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Nanoparticulate agents for magnetic drug delivery systems (DDSs) have extensive applications in targeted drug delivery, contrast imaging and therapeutics. However, no simple synthetic method for magnetic DDS agents has been developed without the need to add magnetic nanoparticles. Here, we describe the one-step fabrication of 'all-in-one' magneto-assemblies using an 'inorganic-metal-salt-free' method, involving spontaneous self-assembly of the water-insoluble prodrug μ-oxo-bis(N,N 0 -ethylenebis (salicylideniminato)iron) [Fe(salen)] (magnetic core) with polypyrrole (PPy)-b-polycaprolactone (PCL) smart diblock copolymers. In the system, PCL serves as a heat-responsive core scaffold, and PPy serves as an electronic core-size controller and pH-responsive shell. This core-shell nanocomposite has a high-loading capacity (~90%), and the core size is tunable by incorporating albumin or gum arabic as bio-coating agents, which also provide colloidal stability, biocompatibility and thermo-stability. Fe(salen), which has intrinsic antitumor activity, also has ubiquitous magnetic properties, which are dramatically enhanced in these molecular assemblies with magnetic coupling. Moreover, these multifunctional nanoassemblies can be delivered magnetically, can serve as magnetic resonance imaging contrast agents, can generate magneto-hyperthermal effects and can enable magnetic field-triggered release of Fe(salen) molecules under acidic conditions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a single-drug anticancer platform

et al. 2017

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“…The theoretical combinations to produce multifunctional probes for multimodal imaging are directly related to the engineered nanomaterials reported until now. Consequently, such combinations could be considered unlimited [8,9,12,13]. Nevertheless, from a practical point of view, these combinations are limited in number because they finally must provide more precise and detailed information for clear diagnosis than the constituting individual modality.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

et al. 2016

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Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient. To this scope, due to their unique features, nanostructured materials have emerged as attractive elements for the development of multifunctional tools for diagnosis and therapy. Hence, in this review, the most recent and relevant advances achieved by applying multifunctional nanostructures in multimodal theranosis of different diseases will be discussed. In more detail, the preparation and application of single multifunctional nano-radiotracers based on iron oxides and enabling PET/MRI dual imaging will be firstly detailed. After that, especially considering their highly promising clinical potential, the preparation and application of multifunctional liposomes useful for multimodal imaging and therapy will be reviewed. In both cases, a special focus will be set on the application of such a multifunctional nanocarriers in cancer as well as cardiovascular diseases.

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“…The angular magnetic field dependence of FMR spectra of 20 single particles and 2 dimers were recorded using a microresonator setup with a sensitivity of 10 6 µ B at X-band frequencies. We determine an effective magnetocrystalline anisotropy field of 2K 4,eff /M = 50 mT ± 5 mT for selected particles, which is smaller than the one of bulk Fe due to the core shell morphology of the particles. The FMR resonances have a linewidth of 4 mT ± 1 mT, corresponding to a magnetic effective damping parameter α = 0.0045 ± 0.0005 matching the values of high quality iron thin films.…”

mentioning

confidence: 99%

Magnetic anisotropy and relaxation of single Fe/FexOy core/shell- nanocubes: A ferromagnetic resonance investigation

et al. 2016

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In this work a full angle dependent Ferromagnetic Resonance (FMR) investigation on a system of 20 separated Fe/FexOy nanocubes without dipolar coupling is reported. The angular magnetic field dependence of FMR spectra of 20 single particles and 2 dimers were recorded using a microresonator setup with a sensitivity of 106 μB at X-band frequencies. We determine an effective magnetocrystalline anisotropy field of 2K4,eff/M = 50 mT ± 5 mT for selected particles, which is smaller than the one of bulk Fe due to the core shell morphology of the particles. The FMR resonances have a linewidth of 4 mT ± 1 mT, corresponding to a magnetic effective damping parameter α = 0.0045 ± 0.0005 matching the values of high quality iron thin films. Numerical calculations taking into account the different angular orientations of the 24 particles with respect to the external magnetic field yield a good agreement to the experiment.

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Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoresponsive Therapy

Cited by 889 publications

References 633 publications

Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a single-drug anticancer platform

Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a single-drug anticancer platform

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

Magnetic anisotropy and relaxation of single Fe/FexOy core/shell- nanocubes: A ferromagnetic resonance investigation

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