Iron oxide nanoparticle encapsulated; folic acid tethered dual metal organic framework-based nanocomposite for MRI and selective targeting of folate receptor expressing breast cancer cells

Pandit, Parimal; Bhagat, Stuti; Rananaware, Pranita; Mohanta, Zinia; Kumar, Manoj; Tiwari, Vivek; Singh, Sanjay; Brahmkhatri, Varsha

doi:10.1016/j.micromeso.2022.112008

Cited by 24 publications

(10 citation statements)

References 56 publications

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“…Pandit et al [ 133 ] synthesized a dual MOF (ZIF‐67‐ZIF‐8) encapsulating iron oxide (IO) and coated with FA as receptor, which was subsequently loaded with Quercetin (Q) as a model drug. Owed to the presence of IO, a superparamagnetic material, the complex had the potential to be used for MRI.…”

Section: Drug‐loaded Mofs For Cancer Treatmentmentioning

confidence: 99%

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Pourmadadi

Ostovar

Eshaghi

et al. 2023

Applied Organom Chemis

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Recently, metal-organic frameworks (MOFs) have received a lot of interest for application in many fields ranging from catalysis, energy storage, and gas sensing to chemosensory and biomedicine owed to their flexible composition, tunable porosity, and easy functionalization ability. In particular, nanoscale MOFs have been broadly investigated as carriers for the delivery of therapeutics to cancerous organs owed to their high encapsulating capacity and controlled cargo release, versatility, biodegradability, and good biocompatibility.Several methods such as solvothermal, mechanochemical, electrochemical, microwave, and ultrasound have been utilized to fabricate MOFs via custommade synthesis. Many efforts have been made to functionalize MOFs through "post-synthetic modification," by adjusting the nature, size, and charge of the linkers or tuning its main components. Herein, a comprehensive literature review on recent papers dealing with drug-loaded MOFs for the detection and treatment of cancer as well as bacterial, fungal, and viral infections is presented. Different types of MOFs applied as carriers in drug delivery systems and biosensing platforms are described. Furthermore, perspectives and challenges for future research in the field, particularly for cancer therapy, are discussed. Thus, very limited literature is available on in vitro and in vivo toxicity of nanoscale MOFs. Besides, their biological stability and long-term safety are crucial factors that should be further investigated. Based on the reviewed papers, zeolite imidazolate framework (ZIF) and Materials of Institute Lavoisier (MIL) families have been the main focus for drug delivery and diagnosis applications, respectively, while many types of MOFs have exhibited antibacterial and antifungal properties regardless of their cargo.

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Section: Drug‐loaded Mofs For Cancer Treatmentmentioning

confidence: 99%

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Pourmadadi

Ostovar

Eshaghi

et al. 2023

Applied Organom Chemis

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“…In another study, Pandit et al successfully developed a folate acid-functionalized Fe 3 O 4 @MOF nanoprobe for MRI of folate receptor-expressing breast cancer cells. 155 Fe 3 O 4 nanoparticles were firstly synthesized by using citrate as the stabilizer and then used to mediate the nucleation and growth of MOFs. Furthermore, folate acid was functionalized with MOF nanocomposites to selectively target folate receptor-expressing breast cancer cells.…”

Section: Biomedical Applications Of Mof Nanocompositesmentioning

confidence: 99%

Surface ligand-assisted synthesis and biomedical applications of metal–organic framework nanocomposites

Wang

et al. 2023

Nanoscale

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“…Metal–organic frameworks (MOFs) are becoming a promising tool for drug delivery applications. Pandit et al [ 115 ] reported the development and fabrication of a dual MOF composite with encapsulated iron oxide (IO) nanoparticles coated with folic acid (FA) as the targeting agent and quercetin (Q) as the drug agent. Due to the presence of SPION, composites inherently show potential use for MRI.…”

Section: Synthetic Magnetic Nanoparticlesmentioning

confidence: 99%

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

et al. 2022

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Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity. The comparative analysis demonstrates that both synthetic and biogenic MNPs could be efficiently used for cancer theranostics, including biosensorics and drug delivery. At the same time, reduced toxicity of biogenic particles was noted, which makes them advantageous for in vivo applications, such as drug delivery, or MRI imaging of tumors. Adaptability to surface modification based on natural biochemical processes is also noted, as well as good compatibility with tumor cells and proliferation in them. Advances in the bionanotechnology field should lead to the implementation of MNPs in clinical trials.

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Iron oxide nanoparticle encapsulated; folic acid tethered dual metal organic framework-based nanocomposite for MRI and selective targeting of folate receptor expressing breast cancer cells

Cited by 24 publications

References 56 publications

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Surface ligand-assisted synthesis and biomedical applications of metal–organic framework nanocomposites

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

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